Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sarah Christine Hobbs"'
Autor:
W. Rycroft, George R. Marshall, Neil Collinson, Mark Stuart Chambers, Angus Murray Macleod, Gerard R. Dawson, John R. Atack, Susan M. Cook, Desmond O'Connor, Sarah Christine Hobbs, Pushpindar Ferris, Robert W. Carling
Publikováno v:
Journal of Medicinal Chemistry. 47:5829-5832
(3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)pyrazolo[1,5-d][1,2,4]triazine (13) has been identified as a functionally selective, inverse agonist at the benzodiazepine site of GABA(A) alpha5 receptors. 13 is orally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ee6f0a465b55f82b6f97720d100921
https://doi.org/10.1021/jm040863t
https://doi.org/10.1021/jm040863t
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 22:333-344
A series of 1,4-benzodiazepin-2-one CCKB receptor antagonists are reported in which substitution at C3 of the benzodiazepine by a phenyl-urea group bearing acidic moieties has generated a chiral centre. As one of these enantiomers is substantially mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d41ae7ca7c32fe84156eccec84e9e77
https://doi.org/10.1081/jlc-100101663
https://doi.org/10.1081/jlc-100101663
Autor:
Sarah Christine Hobbs, Smita Patel, Alison J. Smith, Stephen Robert Fletcher, Victor G. Matassa, Alan P. Watt, Raymond Baker, Stephen B. Freedman, Michael I. Graham, Mark Stuart Chambers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2303-2308
Acylsulphonamide analogues of the meta-tolylurea L-708,474 have been synthesised and evaluated as CCKB receptor antagonists. Such derivatives retain very high affinity and subtype selectivity for the CCKB receptor, and have good aqueous solubility. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be3759b548f37b8d314d39bb4ac9fd8e
https://doi.org/10.1016/0960-894x(95)00399-e
https://doi.org/10.1016/0960-894x(95)00399-e
Autor:
Mark Stuart Chambers, Sarah Christine Hobbs, Richard G. Ball, Alan P. Watt, Stephen Robert Fletcher, Richard H. Herbert, Raymond Baker, Steven R. Thomas, Hugh M. Verrier
Publikováno v:
The Journal of Organic Chemistry. 59:1771-1778
The synthesis of (+)- and (-)-epibatidine (exo-2-(2-chloropyridin-5-yl)-7-azabicyclo[2.2.1]heptane) via reaction of 5-lithio-2-chloropyridine with (+)- and (-)-N-BOC-7-azabicyclo [2.2.1]heptan-2-one is described. The absolute configuration of the nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9add61aea6fa6eba27e526f696391bf3
https://doi.org/10.1021/jo00086a030
https://doi.org/10.1021/jo00086a030
Autor:
Alison J. Smith, Raymond Baker, P. J. Mitchell, Sarah Christine Hobbs, Stephen Robert Fletcher, Victor G. Matassa, Mark Stuart Chambers, Stephen B. Freedman, Alan P. Watt, Smita Patel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1919-1924
The C5-cyclohexyl analogue of the cholecystokinin type-B (CCKB) receptor antagonist L-365,260 has been prepared. This derivative has significantly higher CCKB affinity and markedly improved CCKB/CCKA receptor selectivity (6,500 v. 87-fold) than the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58af792cb6e0a468d342094047936885
https://doi.org/10.1016/s0960-894x(01)80987-2
https://doi.org/10.1016/s0960-894x(01)80987-2
Autor:
Raymond Baker, P. J. Mitchell, Stephen Robert Fletcher, Sarah Christine Hobbs, Mark Stuart Chambers
Publikováno v:
ChemInform. 24
The synthesis of the alkaloid epibatidine {exo-2-(2-chloro-5-pyridyl)-7-azabicyclo[2.2.1]heptane} in enantiomeric form involving, as the critical step, reaction or 5-lithio-2-chloropyridine with N-tert-butoxycarbonyl-7-azabicyclo[2.2.1]heptan-2-one i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df0171c197210ebf088996598e764fd6
https://doi.org/10.1002/chin.199344292
https://doi.org/10.1002/chin.199344292
Autor:
Sarah Christine Hobbs, Alan P. Watt, Mark Stuart Chambers, Raymond Baker, Hugh M. Verrier, Richard H. Herbert, Richard G. Ball, Stephen Robert Fletcher, Steven R. Thomas
Publikováno v:
ChemInform. 25
The synthesis of (+)- and (-)-epibatidine (exo-2-(2-chloropyridin-5-yl)-7-azabicyclo[2.2.1]heptane) via reaction of 5-lithio-2-chloropyridine with (+)- and (-)-N-BOC-7-azabicyclo [2.2.1]heptan-2-one is described. The absolute configuration of the nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab42cbf7b3bfa277f562214646dab282
https://doi.org/10.1002/chin.199436249
https://doi.org/10.1002/chin.199436249
Autor:
Michael I. Graham, Alan P. Watt, Alison J. Smith, Victor G. Matassa, Raymond Baker, Stephen B. Freedman, Mark Stuart Chambers, Stephen Robert Fletcher, Smita Patel, Sarah Christine Hobbs
Publikováno v:
ChemInform. 27
Acylsulphonamide analogues of the meta-tolylurea L-708,474 have been synthesised and evaluated as CCKB receptor antagonists. Such derivatives retain very high affinity and subtype selectivity for the CCKB receptor, and have good aqueous solubility. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6058f2807b6ef34f82341a3153d42dfb
https://doi.org/10.1002/chin.199608173
https://doi.org/10.1002/chin.199608173
Autor:
Helen Jane Szekeres, Matthew P. Braun, Angus Murray Macleod, Desmond O'Connor, Nicola Szeto, Robert James Maxey, Philip Jones, Keith A. Wafford, Mark Stuart Chambers, Brian P. Cato, Susan M. Cook, John R. Atack, Sarah Christine Hobbs
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(4)
(3- tert -Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1 H -1,2,4-triazol-5-ylmethoxy)pyrazolo[1,5- d ][1,2,4]triazine ( 1 ) was recently identified as a functionally selective, inverse agonist at the benzodiazepine site of GABA A α5 receptors and en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d5fc995bbb7200195d0d55186acede
https://pubmed.ncbi.nlm.nih.gov/16303300
https://pubmed.ncbi.nlm.nih.gov/16303300
Autor:
Karen A. Maubach, Gerard R. Dawson, Susan M. Cook, Howard B. Broughton, Angus Murray Macleod, John R. Atack, Sarah Christine Hobbs, George R. Marshall, Mark Stuart Chambers, and Austin J. Reeve, Neil Collinson, Goplan V. Pillai
Publikováno v:
Journal of medicinal chemistry. 46(11)
In pursuit of a GABA(A) alpha5-subtype-selective inverse agonist to enhance cognition, a series of 6,7-dihydro-2-benzothiophen-4(5H)-ones has been identified as a novel class of GABA(A) receptor ligands. These thiophenes have higher binding affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910ffd4ee1958a036c41858d047b898d
https://pubmed.ncbi.nlm.nih.gov/12747794
https://pubmed.ncbi.nlm.nih.gov/12747794