Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sarah Choung"'
Autor:
Erin R. Spiller, Nolan Ung, Seungil Kim, Katherin Patsch, Roy Lau, Carly Strelez, Chirag Doshi, Sarah Choung, Brandon Choi, Edwin Francisco Juarez Rosales, Heinz-Josef Lenz, Naim Matasci, Shannon M. Mumenthaler
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Three-quarters of compounds that enter clinical trials fail to make it to market due to safety or efficacy concerns. This statistic strongly suggests a need for better screening methods that result in improved translatability of compounds during the
Externí odkaz:
https://doaj.org/article/bec0df2719ab48b1a20e97ae10530083
Autor:
Erin Spiller, Natasha Hashemi, Jasmine Foo, Roy Lau, Nolan Ung, Jordan Gasho, Ren X. Sun, Sarah Choung, Seung Il Kim, Emma J. Fong, Shannon M. Mumenthaler
Publikováno v:
Slas Discovery
3D cell culture models have been developed to better mimic the physiological environments that exist in human diseases. As such, these models are advantageous over traditional 2D cultures for screening drug compounds. However, the practicalities of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c67666f947b0873ec64901dfeab6cf
https://doi.org/10.1177/2472555220915827
https://doi.org/10.1177/2472555220915827
Publikováno v:
Cancer Research. 77:5786-5786
Patient derived organoids are becoming a popular 3D in vitro model that more accurately recapitulate in vivo conditions compared to standard 2D culture systems. Organoids consist of epithelial cells and lack stroma and mesenchyme, allowing cells of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa81f23f1d0e28935f5be6efd18dcdbc
https://doi.org/10.1158/1538-7445.am2017-5786
https://doi.org/10.1158/1538-7445.am2017-5786
Publikováno v:
Clinical Cancer Research. 22:A18-A18
Organoids are an emerging model system that more closely recapitulates the in vivo environment compared to traditional monolayer systems. Using patient-derived samples grown in a 3D matrix, we hope to advance personalized medicine by providing more p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e0eb912bcac50d7419109dfc500809f
https://doi.org/10.1158/1557-3265.pdx16-a18
https://doi.org/10.1158/1557-3265.pdx16-a18