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Autor:
Raymond Houssin, Michael Facompré, Nicole Pommery, Christian Bailly, Sarah Catoen-Chackal, Pierre Colson, Jean-Pierre Hénichart, Jean-François Goossens
Publikováno v:
Journal of Medicinal Chemistry. 47:3665-3673
The tetrahydroindeno[1,2-b]pyrido[4,3,2-de]quinoline chromophore was initially designed as a DNA intercalating unit because of its planar structure. Unexpectedly, one molecule (15d) bearing two N-methylpiperazine chains on both sides of this condense