Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sarah Cappuyns"'
Autor:
Marta Piqué-Gili, Carmen Andreu-Oller, Agavni Mesropian, Roger Esteban-Fabró, Marina Bárcena-Varela, Marina Ruiz de Galarreta, Carla Montironi, Iris Martinez-Quetglas, Sarah Cappuyns, Judit Peix, Ieva Keraite, Albert Gris-Oliver, Elisa Fernández-Martínez, Ezequiel Mauro, Miguel Torres-Martin, Jordi Abril-Fornaguera, Katherine E. Lindblad, Diether Lambrechts, Jeroen Dekervel, Swan N. Thung, Daniela Sia, Amaia Lujambio, Roser Pinyol, Josep M. Llovet
Publikováno v:
JHEP Reports, Vol 6, Iss 11, Pp 101212- (2024)
Background & Aims: Transforming growth factor β (TGF-β) plays an oncogenic role in advanced cancer by promoting cell proliferation, metastasis and immunosuppression. PMEPA1 (prostate transmembrane protein androgen induced 1) has been shown to promo
Externí odkaz:
https://doaj.org/article/93d51b39e7c4419c83008f56aa023b9c
Autor:
Frederik Peeters, Sarah Cappuyns, Marta Piqué-Gili, Gino Phillips, Chris Verslype, Diether Lambrechts, Jeroen Dekervel
Publikováno v:
JHEP Reports, Vol 6, Iss 7, Pp 101094- (2024)
Summary: Primary liver cancer, more specifically hepatocellular carcinoma (HCC), remains a significant global health problem associated with increasing incidence and mortality. Clinical, biological, and molecular heterogeneity are well-known hallmark
Externí odkaz:
https://doaj.org/article/3ecd1736b2c244978a0ba2bc4c8b06f3
Autor:
Sarah Cappuyns, Gino Philips, Vincent Vandecaveye, Bram Boeckx, Rogier Schepers, Thomas Van Brussel, Ingrid Arijs, Aurelie Mechels, Ayse Bassez, Francesca Lodi, Joris Jaekers, Halit Topal, Baki Topal, Orian Bricard, Junbin Qian, Eric Van Cutsem, Chris Verslype, Diether Lambrechts, Jeroen Dekervel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The combination of atezolizumab plus bevacizumab (atezo/bev) has dramatically changed the treatment landscape of advanced HCC (aHCC), achieving durable responses in some patients. Using single-cell transcriptomics, we characterize the intra-
Externí odkaz:
https://doaj.org/article/db4b12030ddd4fd095ec4bcc29c92ddb
Autor:
Sarah Cappuyns, Josep M. Llovet
Publikováno v:
Clin Cancer Res
Atezolizumab + bevacizumab is the new standard of care for systemic treatment-naïve, unresectable hepatocellular carcinoma (HCC). This exploratory study investigated on-treatment alpha-fetoprotein (AFP) response as a potential surrogate biomarker of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063b0650dea4972ebf262596ab6557b7
https://doi.org/10.1158/1078-0432.ccr-22-1213
https://doi.org/10.1158/1078-0432.ccr-22-1213
Autor:
Francesca Lodi, Sam Vanmassenhove, Elena Donders, Pierre Van Mol, Amelie Franken, Sarah Cappuyns, Ayse Bassez, Siel Olbrecht, Liselore Loverix, Michel Bila, Hanne Vos, Joanna Pozniak, Kevin Punie, Diether Lambrechts
Publikováno v:
Cancer Research. 83:5785-5785
The tumor microenvironment (TME) shapes response to immune checkpoint blockade (ICB). Several pan-cancer single-cell RNA-sequencing (scRNA-seq) analyses have reported how TME heterogeneity profoundly differs between cancer types. These studies mainly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2de606a73a02b8a6c869ba682ff6a2a
https://doi.org/10.1158/1538-7445.am2023-5785
https://doi.org/10.1158/1538-7445.am2023-5785
Autor:
Sarah Cappuyns, Matthias Verbesselt, Alexander Van De Bruaene, Jan Bogaert, Lucienne Michaux, Michel Delforge
Publikováno v:
European Heart Journal - Case Reports. 6
Background Light-chain amyloidosis has always been described as a sporadic disease caused by plasma cell dyscrasia. Cardiac amyloidosis refers to cardiac involvement with infiltration of amyloid fibrils in the myocardium. The degree of cardiac involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7d344e4fe8b69b234be5a5d680a64a
https://doi.org/10.1093/ehjcr/ytac084
https://doi.org/10.1093/ehjcr/ytac084
Autor:
Cedric Brackenier, Lisa Kinget, Sarah Cappuyns, Chris Verslype, Benoit Beuselinck, Jeroen Dekervel
Publikováno v:
Cancers. 15:348
Tyrosine kinase inhibitors (TKIs) with antiangiogenic properties, such as sorafenib, have been the standard choice to systemically treat hepatocellular carcinoma for over a decade. More recently, encouraging results were obtained using immune checkpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d65c724241b7ce2ab26fb653f57c744
https://doi.org/10.3390/cancers15020348
https://doi.org/10.3390/cancers15020348
Autor:
Sarah Cappuyns, Gino Philips, Vincent Vandecaveye, Chris Verslype, Eric Van Cutsem, Diether Lambrechts, Jeroen Derkervel
Publikováno v:
Clinical Cancer Research. 28:PR03-PR03
The novel combination of atezolizumab/bevacizumab has demonstrated unprecedented response rates in a subgroup of advanced hepatocellular carcinoma (aHCC) patients. In order to understand why only a subset of aHCC patients respond to immunotherapy tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e45531c920917768d79aca2057c91f9
https://doi.org/10.1158/1557-3265.liverca22-pr03
https://doi.org/10.1158/1557-3265.liverca22-pr03
Autor:
Sarah Cappuyns, Gino Philips, Vincent Vandecaveye, Chris Verslype, Eric Van Cutsem, Diether Lambrechts, Jeroen Dekervel
Publikováno v:
Journal of Hepatology. 77:S385
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c939fd9f718a3513a9fc1b5abb613790
https://doi.org/10.1016/s0168-8278(22)01122-9
https://doi.org/10.1016/s0168-8278(22)01122-9
Autor:
Jeroen Dekervel, Matthias Van Haele, Sarah Cappuyns, Eric Van Cutsem, Bernard Thienpont, Jos van Pelt, Tom Venken, Diether Lambrechts, Tania Roskams, Eva Galle, Chris Verslype, Pieter Busschaert
Publikováno v:
Clinical Epigenetics
Background Overcoming therapeutic resistance is one of the major hurdles in cancer care. One mechanism contributing to therapeutic resistance is a process in which epithelial cells switch to a mesenchymal state (epithelial-to-mesenchymal transition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f456a48f425f5d7b8557e36207bb81
https://doi.org/10.1186/s13148-020-0821-z
https://doi.org/10.1186/s13148-020-0821-z