Agrp neuron activity is required for alcohol-induced overeating

Autor: Sarah Cains, Craig Blomeley, Mihaly Kollo, Romeo Rácz, Denis Burdakov

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)

It is well known that alcohol consumption leads to overeating however the neural mechanisms are unclear. Here the authors demonstrate that hunger promoting Agrp neurons in hypothalamus are also activated by ethanol and are necessary for ethanol-induc

Externí odkaz: https://doaj.org/article/0060c7d2281240ac88bb52ce6920f9e0

Subarachnoid cerebrospinal fluid is essential for normal development of the cerebral cortex

Autor: Alicia Requena Jimenez, Jaleel A. Miyan, Naila Naz, David Bueno, Sarah Cains, A. Gato, Stephanie Larcombe

Publikováno v: Miyan, J, Cains, S, Larcombe, S, Naz, N, Requena Jimenez, A, Bueno, D & Gato, A 2019, ' Subarachnoid cerebrospinal fluid is essential for normal development of the cerebral cortex ', Seminars in Cell and Developmental Biology, vol. 102, pp. 28-39 . https://doi.org/10.1016/j.semcdb.2019.11.011

The central nervous system develops around a fluid filled space which persists in the adult within the ventricles, spinal canal and around the outside of the brain and spinal cord. Ventricular fluid is known to act as a growth medium and stimulator o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ca214725786e61d4a34cfdd9411561
https://pure.manchester.ac.uk/ws/files/151617740/SemCellDevBiol_revision_11_2019.docx

Ethanol Affects Striatal Interneurons Directly and Projection Neurons Through a Reduction in Cholinergic Tone

Autor: Craig Blomeley, Richard Smith, Sarah Cains, Enrico Bracci

Publikováno v: Neuropsychopharmacology

The acute effects of ethanol on the neurons of the striatum, a basal ganglia nucleus crucially involved in motor control and action selection, were investigated using whole-cell recordings. An intoxicating concentration of ethanol (50 mM) produced in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e575d44020f284c9f4f1a9d8577cac1
https://doi.org/10.1038/npp.2010.241

Addressing a folate imbalance in fetal cerebrospinal fluid can decrease the incidence of congenital hydrocephalus

Autor: Penelope Jane Owen-Lynch, Sarah Cains, Mohammad Nabiuni, Jaleel A. Miyan, Andrew J. Shepherd

Publikováno v: Journal of neuropathology and experimental neurology. 68(4)

Fetal-onset hydrocephalus (HC), which affects between 1:500 and 1:5000 live human births, results from unequal production and drainage of cerebrospinal fluid (CSF) and is associated with abnormal development of the cerebral cortex leading to severe n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37273425cb501e5931193b8f3ca24e12
https://pubmed.ncbi.nlm.nih.gov/19287311

Curly-tail mice with neural tube defects show abnormal cortical development

Autor: Jaleel A. Miyan, Chloe Duval, Hussain Moudahi, Dawn Savery, Andrew J. Copp, Sarah Cains

Publikováno v: University of Manchester-PURE

BackgroundOur past work suggests a vital role for cerebrospinal fluid (CSF) in normal cortical development. Abnormal cortical development occurs from the earliest stages following fluid obstruction in the developing brain of a hydrocephalic fetus. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bda15d047642f81d07d3cc8f29e3c85