Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy

Autor: Larissa B. Teixeira, Lucas T. Parreiras-e-Silva, Thiago Bruder-Nascimento, Diego A. Duarte, Sarah C. Simões, Rafael M. Costa, Deisy Y. Rodríguez, Pedro A. B. Ferreira, Carlos A. A. Silva, Emiliana P. Abrao, Eduardo B. Oliveira, Michel Bouvier, Rita C. Tostes, Claudio M. Costa-Neto

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Abstract The renin-angiotensin system (RAS) plays a key role in the control of vasoconstriction as well as sodium and fluid retention mediated mainly by angiotensin (Ang) II acting at the AT1 receptor (AT1R). Ang-(1-7) is another RAS peptide, identif

Externí odkaz: https://doaj.org/article/2fef525bd7c04daf974776365ec10caf

Design and Synthesis of New Chacones Substituted with Azide/Triazole Groups and Analysis of Their Cytotoxicity Towards HeLa Cells

Autor: José A. F. P. Villar, Gustavo H. R. Viana, Leandro A. Barbosa, Fernando P. Varotti, Sarah C. Simões, Andersson Barison, Estrela M. P. V. E. Souza, Marina G. da Silva, Graziele D. da Silva

Publikováno v: Molecules, Vol 17, Iss 9, Pp 10331-10343 (2012)

A series of new chalcones substituted with azide/triazole groups were designed and synthesized, and their cytotoxic activity was evaluated in vitro against the HeLa cell line. O-Alkylation, Claisen-Schmidt condensation and Cu(I)-catalyzed cycloadditi

Externí odkaz: https://doaj.org/article/712b200d3ff84d7a9597cda58f3e5de1

Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands - Functional characterization and modeling studies on H

Autor: Michelle F, Corrêa, André L, Balico-Silva, Dóra J, Kiss, Gustavo A B, Fernandes, Jhonatan C, Maraschin, Lucas T, Parreiras-E-Silva, Marina T, Varela, Sarah C, Simões, Michel, Bouvier, György M, Keserű, Claudio M, Costa-Neto, João Paulo S, Fernandes

Publikováno v: Bioorganicmedicinal chemistry. 30

Histamine acts through four different receptors (H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8284780f15c6f6a8f64fe82db7c9bd09
https://pubmed.ncbi.nlm.nih.gov/33333448

Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors

Autor: Michel Bouvier, Viktoriya Lukasheva, Sarah C. Simões, Yubo Cao, Larissa B. Teixeira, Christian LeGouill, Dominic Devost, Jean-Michel Longpré, Graciela Piñeyro, Richard Leduc, Sahil Kumar, Yoon Namkung, Stéphane A. Laporte, Terence E. Hébert, Jenna Giubilaro, Claudio M. Costa-Neto

Publikováno v: Science signaling. 11(559)

G protein-coupled receptors (GPCRs) are important therapeutic targets that exhibit functional selectivity (biased signaling), in which different ligands or receptor variants elicit distinct downstream signaling. Understanding all the signaling events

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf2aeee9fadb22c17f3e46e957eed02
https://pubmed.ncbi.nlm.nih.gov/30514808

Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential

Autor: Diego A. Duarte, Michel Bouvier, Claudio M. Costa-Neto, Richardt G. Landgraf, Larissa B. Teixeira, Aleksandro Martins Balbino, João Paulo S. Fernandes, Álefe Jhonatas Ramos Barbosa, Sarah C. Simões, Michelle Fidelis Corrêa, Lucas T. Parreiras-e-Silva

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The histamine receptors (HRs) are traditional G protein-coupled receptors of extensive therapeutic interest. Recently, H3R and H4R subtypes have been targeted in drug discovery projects for inflammation, asthma, pain, cancer, Parkinson's, and Alzheim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d46f24c8a58462cc1477463ef8a51c
http://journal.frontiersin.org/article/10.3389/fphar.2017.00825/full