Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sarah C. Mansour"'
Autor:
Heidi Wolfmeier, Sarah C. Mansour, Leo T. Liu, Daniel Pletzer, Annette Draeger, Eduard B. Babiychuk, Robert E.W. Hancock
Publikováno v:
EBioMedicine, Vol 33, Iss , Pp 211-217 (2018)
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), typified by the pulse-field type USA300, is an emerging endemic pathogen that is spreading rapidly among healthy people. CA-MRSA causes skin and soft tissue infections, life-
Externí odkaz:
https://doaj.org/article/015e710ff6b84a8094608431c5de5ae3
Autor:
Sarah C. Mansour, Daniel Pletzer, César de la Fuente-Núñez, Paul Kim, Gordon Y.C. Cheung, Hwang-Soo Joo, Michael Otto, Robert E.W. Hancock
Publikováno v:
EBioMedicine, Vol 12, Iss C, Pp 219-226 (2016)
Cutaneous abscess infections are difficult to treat with current therapies and alternatives to conventional antibiotics are needed. Understanding the regulatory mechanisms that govern abscess pathology should reveal therapeutic interventions for thes
Externí odkaz:
https://doaj.org/article/8e89fdac40bf446b975803bfb54344a9
Autor:
César de la Fuente-Núñez, Sarah C. Mansour, Zhejun Wang, Lucy Jiang, Elena B.M. Breidenstein, Melissa Elliott, Fany Reffuveille, David P. Speert, Shauna L. Reckseidler-Zenteno, Ya Shen, Markus Haapasalo, Robert E.W. Hancock
Publikováno v:
Antibiotics, Vol 3, Iss 4, Pp 509-526 (2014)
Cystic fibrosis (CF) patients often acquire chronic respiratory tract infections due to Pseudomonas aeruginosa and Burkholderia cepacia complex (Bcc) species. In the CF lung, these bacteria grow as multicellular aggregates termed biofilms. Biofilms d
Externí odkaz:
https://doaj.org/article/1120db610f2e4160b89de1b518988b83
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
ABSTRACT Only a few, relatively cumbersome animal models enable long-term Gram-negative bacterial infections that mimic human situations, where untreated infections can last for weeks. Here, we describe a simple murine cutaneous abscess model that en
Externí odkaz:
https://doaj.org/article/53fda5d510254148b4e905a114d170d6
Autor:
Anthony D. Verderosa, Sarah C. Mansour, César de la Fuente-Núñez, Robert E. W. Hancock, Kathryn E. Fairfull-Smith
Publikováno v:
Molecules, Vol 21, Iss 7, p 841 (2016)
As bacterial biofilms are often refractory to conventional antimicrobials, the need for alternative and/or novel strategies for the treatment of biofilm related infections has become of paramount importance. Herein, we report the synthesis of novel h
Externí odkaz:
https://doaj.org/article/8601682b398649e699550d39bc1416d0
Autor:
Robert E. W. Hancock, Kathryn E. Fairfull-Smith, Christopher Barner-Kowollik, Leonie Barner, Vanessa Trouillet, Alexander Welle, Daniel Pletzer, Michael J. Trimble, Hendrik Woehlk, Sarah C. Mansour
Publikováno v:
Polymer Chemistry. 10:4252-4258
Bacterial biofilm formation on medical devices is a threat to healthcare systems worldwide as bacteria within a biofilm are more resistant to standard antimicrobial therapies. Herein, we introduce a nitroxide-based antibiofilm coating strategy, which
Autor:
Leo T. Liu, Heidi Wolfmeier, Sarah C. Mansour, Robert E. W. Hancock, Daniel Pletzer, Eduard B. Babiychuk, Annette Draeger
Publikováno v:
Wolfmeier, Heidi Annemarie; Mansour, Sarah C; Liu, Leo T; Pletzer, Daniel; Draeger, Annette; Babiychuk, Eduard; Hancock, Robert E W (2018). Liposomal Therapy Attenuates Dermonecrosis Induced by Community-Associated Methicillin-Resistant Staphylococcus aureus by Targeting α-Type Phenol-Soluble Modulins and α-Hemolysin. EBioMedicine, 33, pp. 211-217. Elsevier 10.1016/j.ebiom.2018.06.016
EBioMedicine
EBioMedicine, Vol 33, Iss, Pp 211-217 (2018)
EBioMedicine
EBioMedicine, Vol 33, Iss, Pp 211-217 (2018)
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), typified by the pulse-field type USA300, is an emerging endemic pathogen that is spreading rapidly among healthy people. CA-MRSA causes skin and soft tissue infections, life-
Publikováno v:
ACS Infectious Diseases. 4:93-106
Microbial biofilms, which are elaborate and highly resistant microbial aggregates formed on surfaces or medical devices, cause two-thirds of infections and constitute a serious threat to public health. Immunocompromised patients, individuals who requ
Autor:
Timothy K. Lu, Kathryn E. Fairfull-Smith, Sarah C. Mansour, Robert E. W. Hancock, Jicong Cao, Cesar de la Fuente-Nunez, Anthony D. Verderosa
Publikováno v:
European Journal of Medicinal Chemistry. 138:590-601
As bacterial biofilms display extreme tolerance to conventional antibiotic treatments, it has become imperative to develop new antibacterial strategies with alternative mechanisms of action. Herein, we report the synthesis of a series of ciprofloxaci
Publikováno v:
Emerging Topics in Life Sciences. 1:41-53
Biofilms represent an adaptive lifestyle where microbes grow as structured aggregates in many different environments, e.g. on body surfaces and medical devices. They are a profound threat in medical (and industrial) settings and cause two-thirds of a