Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sarah C. Lappin"'
Autor:
Kim Winborn, Sarah C. Lappin, James S. Wright, Vicky Holland, Martin J. Gunthorpe, Harshad Kantilal Rami, Andrew D. Randall, Sandra Arpino, Graham D Smith, Julie Egerton, Stephen J. Brough, Mervyn Thompson, Jeffrey C. Jerman, Sara Luis Hannan, Darren Smart, John B. Davis
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:1183-1192
Vanilloid receptor-1 (TRPV1) is a nonselective cation channel, predominantly expressed by sensory neurons, which plays a key role in the detection of noxious painful stimuli such as capsaicin, acid, and heat. TRPV1 antagonists may represent novel the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519bdcb9b1541b2a29cae2ecf14a8d24
https://doi.org/10.1124/jpet.106.116657
https://doi.org/10.1124/jpet.106.116657
Publikováno v:
European Journal of Pharmacology. 540:73-81
The anti-hyperalgesic effects of TRPV1 receptor antagonists are well documented in animal models of pain, however, the precise site of their action is not known. Here we have examined the effects of the selective TRPV1 antagonist SB-366791 on glutama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756be690982f32a3da9b54f77d650d0d
https://doi.org/10.1016/j.ejphar.2006.04.046
https://doi.org/10.1016/j.ejphar.2006.04.046
Autor:
S. Nasir, Angela Worby, Catherine H. Gill, Harshad Kantilal Rami, Wyman Paul Adrian, Jeffrey C. Jerman, Andrew D. Randall, John B. Davis, Mervyn Thompson, Darren Smart, Julie Egerton, Ellen M. Soffin, Davina E. Owen, Graham D Smith, Ceri H. Davies, Sarah C. Lappin, Martin J. Gunthorpe, L. Howett, S. Luis Hannan
Publikováno v:
Neuropharmacology. 46:133-149
Vanilloid receptor-1 (TRPV1) is a non-selective cation channel, predominantly expressed by peripheral sensory neurones, which is known to play a key role in the detection of noxious painful stimuli, such as capsaicin, acid and heat. To date, a number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd1e6a3014674523ef11c19bfa10804
https://doi.org/10.1016/s0028-3908(03)00305-8
https://doi.org/10.1016/s0028-3908(03)00305-8
Autor:
Stephen J. Medhurst, Sandra Arpino, James Wright, Darren Jason Mitchell, Alexander J. Stevens, James Biggs, Kim Winborn, Susan Marie Westaway, John B. Davis, Jeffrey C. Jerman, Vicky Holland, Tanya Coleman, Jennifer E. Cryan, Geoffrey Stemp, Sarah C. Lappin, Jon T. Seal, Harshad Kantilal Rami, Leontine Saskia Trouw, Mervyn Thompson, Martin J. Gunthorpe
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(20)
6-Phenylnicotinamide (2) was previously identified as a potent TRPV1 antagonist with activity in an in vivo model of inflammatory pain. Optimization of this lead through modification of both the biaryl and heteroaryl components has resulted in the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b365ea545812a5b73fbe175229b22f
https://pubmed.ncbi.nlm.nih.gov/18809327
https://pubmed.ncbi.nlm.nih.gov/18809327
Autor:
Andrew D. Randall, Sarah C. Lappin, Stuart Cobb, Nicolle C.L. McNaughton, Nadia Shivji, Catherine H. Gill, Clare E. Farmer, Jon T. Brown, Ceri H. Davies
Publikováno v:
Synapse (New York, N.Y.). 59(5)
Hyperpolarization-activated cyclic nucleotide gated (HCN) ion channels regulate membrane potential, neurotransmitter release, and patterning of synchronized neuronal activity. Currently, there is an intense debate as to whether or not these ion chann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d01650c959f6ba9ca6dbb5bfeb5857d
https://pubmed.ncbi.nlm.nih.gov/16421904
https://pubmed.ncbi.nlm.nih.gov/16421904
Publikováno v:
Brain research. 1065(1-2)
The role of calcium-activated potassium channels in the regulation of neuronal hyperexcitability, as in epilepsy, is unclear. To examine this issue, we have used the acute hippocampal slice model of epileptiform activity to investigate the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e4f29f17be59510bdc49a2859ec641
https://pubmed.ncbi.nlm.nih.gov/16336949
https://pubmed.ncbi.nlm.nih.gov/16336949