Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sarah C. Krassnig"'
Autor:
Johannes Gregor Matthias Rack, Qiang Liu, Valentina Zorzini, Jim Voorneveld, Antonio Ariza, Kourosh Honarmand Ebrahimi, Julia M. Reber, Sarah C. Krassnig, Dragana Ahel, Gijsbert A. van der Marel, Aswin Mangerich, James S. O. McCullagh, Dmitri V. Filippov, Ivan Ahel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
PARG and ARH3 are the main hydrolases to reverse serine poly(ADP-ribosylation) yet their activities in the process differ. Here, the authors synthesise linear and branched poly(ADP-ribose) molecules, perform structure-function analysis and elucidate
Externí odkaz:
https://doaj.org/article/4bbd22b00672441db09292221ae3ea22
Autor:
Kourosh Honarmand Ebrahimi, Ivan Ahel, Aswin Mangerich, Jim Voorneveld, Gijsbert A. van der Marel, Dmitri V. Filippov, Valentina Zorzini, Julia M. Reber, James S. O. McCullagh, Johannes Gregor Matthias Rack, Sarah C. Krassnig, Dragana Ahel, Antonio Ariza, Qiang Liu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, 12. NATURE PORTFOLIO
Nature Communications
Nature Communications, 12. NATURE PORTFOLIO
Poly(ADP-ribosyl)ation (PAR) is a versatile and complex posttranslational modification composed of repeating units of ADP-ribose arranged into linear or branched polymers. This scaffold is linked to the regulation of many of cellular processes includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5bf3c887354c4c6d8e141ae3e7c49d
https://doi.org/10.1038/s41467-021-24723-3
https://doi.org/10.1038/s41467-021-24723-3
Autor:
Dragana Ahel, Danique Beijer, Marcin J. Suskiewicz, Joséphine Groslambert, Nicole Kaminski, Ivan Ahel, Sarah C. Krassnig, Evgeniia Prokhorova, Jonathan Baets, Michael Tellier, Shona Murphy, Kang Zhu, Thomas Agnew, Michael L. Nielsen, Roderick J. O’Sullivan, Julia M. Reber, Aswin Mangerich, James Holder, Anne R. Wondisford, Luca Palazzo
Publikováno v:
Mol Cell
Molecular cell
Molecular Cell
Prokhorova, E, Agnew, T, Wondisford, A R, Tellier, M, Kaminski, N, Beijer, D, Holder, J, Groslambert, J, Suskiewicz, M J, Zhu, K, Reber, J M, Krassnig, S C, Palazzo, L, Murphy, S, Nielsen, M L, Mangerich, A, Ahel, D, Baets, J, O'Sullivan, R J & Ahel, I 2021, ' Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease ', Molecular Cell, vol. 81, no. 12, pp. 2640-2655 . https://doi.org/10.1016/j.molcel.2021.04.028
Molecular cell
Molecular Cell
Prokhorova, E, Agnew, T, Wondisford, A R, Tellier, M, Kaminski, N, Beijer, D, Holder, J, Groslambert, J, Suskiewicz, M J, Zhu, K, Reber, J M, Krassnig, S C, Palazzo, L, Murphy, S, Nielsen, M L, Mangerich, A, Ahel, D, Baets, J, O'Sullivan, R J & Ahel, I 2021, ' Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease ', Molecular Cell, vol. 81, no. 12, pp. 2640-2655 . https://doi.org/10.1016/j.molcel.2021.04.028
Summary ARH3/ADPRHL2 and PARG are the primary enzymes reversing ADP-ribosylation in vertebrates, yet their functions in vivo remain unclear. ARH3 is the only hydrolase able to remove serine-linked mono(ADP-ribose) (MAR) but is much less efficient tha
Autor:
Rack, Johannes Gregor Matthias, Liu, Qiang, Zorzini, Valentina, Voorneveld, Jim, Ariza, Antonio, Honarmand Ebrahimi, Kourosh, Reber, Julia M., Krassnig, Sarah C., Ahel, Dragana, van der Marel, Gijsbert A., Mangerich, Aswin, McCullagh, James S. O., Filippov, Dmitri V., Ahel, Ivan
Publikováno v:
Nature Communications; 7/28/2021, Vol. 12 Issue 1, p1-14, 14p