Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sarah C. Good"'
Autor:
David J. Brockwell, Sarah C. Good, Patricija van Oosten-Hawle, G. Nasir Khan, Jemma Makepeace, Ciaran P. A. Doherty, Roberto Maya-Martinez, Sheena E. Radford, Sabine M. Ulamec
Publikováno v:
Nature structural & molecular biology
Aggregation of human α-synuclein (αSyn) is linked to Parkinson’s disease (PD) pathology. The central region of the αSyn sequence contains the non-amyloid β-component (NAC) crucial for aggregation. However, how NAC flanking regions modulate αSy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829987ccdb5ab2393b3c809b54e09639
https://doi.org/10.1038/s41594-020-0384-x
https://doi.org/10.1038/s41594-020-0384-x
Autor:
Wing-Yiu Choy, Jose Marques-Lopes, Marco A. M. Prado, Stephen H. Pasternak, Vania F. Prado, Rachel E. Lackie, Sarah C. Good, Patricija van Oosten-Hawle, Valeriy G. Ostapchenko
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Molecular chaperones and co-chaperones, which are part of the protein quality control machinery, have been shown to regulate distinct aspects of Alzheimer’s Disease (AD) pathology in multiple ways. Notably, the co-chaperone STI1, which presents inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152fe61ee52f6323c90243b8c843d94b
http://europepmc.org/articles/PMC7441634
http://europepmc.org/articles/PMC7441634
Age-associated protein homeostasis diseases, such as Parkinson’s or Alzheimer’s disease, are caused by the misfolding and aggregation of proteins, disrupting essential cellular processes and resulting in cell death. Throughout life, cellular heal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1726472d2b3b07ba918d73da33ffd91f
https://doi.org/10.1016/b978-0-12-819132-3.00003-8
https://doi.org/10.1016/b978-0-12-819132-3.00003-8
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10752, p 10752 (2021)
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10752, p 10752 (2021)
Aggregation of β2 microglobulin (β2m) into amyloid fibrils is associated with systemic amyloidosis, caused by the deposition of amyloid fibrils containing the wild-type protein and its truncated variant, ΔN6 β2m, in haemo-dialysed patients. A sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aebd315e24b574a786356dfe80775f62
https://doi.org/10.3390/ijms221910752
https://doi.org/10.3390/ijms221910752
Autor:
Rebecca Aston, Catrin E. Smith, Laura M. Jones, Jo Miles, Patricija van Oosten-Hawle, M. S. Vijayabaskar, Daniel O’Brien, David R. Westhead, Sarah C. Good
Publikováno v:
Cell Reports
Cell Reports, Vol 23, Iss 13, Pp 3905-3919 (2018)
Cell Reports, Vol 23, Iss 13, Pp 3905-3919 (2018)
Summary In metazoans, tissues experiencing proteotoxic stress induce “transcellular chaperone signaling” (TCS) that activates molecular chaperones, such as hsp-90, in distal tissues. How this form of inter-tissue communication is mediated to upre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8c8720f81ffb19b65e210277598d3a
https://eprints.whiterose.ac.uk/131506/8/1-s2.0-S221112471830874X-main.pdf
https://eprints.whiterose.ac.uk/131506/8/1-s2.0-S221112471830874X-main.pdf
Publikováno v:
Frontiers in Human Neuroscience, Vol 12 (2018)
Decades of research have established the importance of the hippocampus for episodic and spatial memory. In spatial navigation tasks, the role of the hippocampus has been classically juxtaposed with the role of the dorsal striatum, the latter of which
Externí odkaz:
https://doaj.org/article/1dfa865272dd4471ade39b69c323891a
Autor:
Sarah C. Goode DNP, FNP-C, Jacqueline L. Beshears FNP-BC, Russell D. Goode MD, Theresa F. Wright DNP, RN, CCRC, Anita King DNP, MA, FNP, CDE, FAADE, Brett D. Crist MD
Publikováno v:
Geriatric Orthopaedic Surgery & Rehabilitation, Vol 8 (2017)
Introduction: This prospective study sought to implement a screening tool to identify and risk stratify at-risk patients for osteoporosis and evaluate patient knowledge of osteoporosis and fragility fractures in an orthopedic trauma clinic affiliated
Externí odkaz:
https://doaj.org/article/5ccf185ebd744c72b7ab55d3a415ec2c