Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sarah C. Genzer"'
Autor:
Teresa E. Sorvillo, Elif Karaaslan, Florine E. M. Scholte, Stephen R. Welch, JoAnn D. Coleman-McCray, Sarah C. Genzer, Jana M. Ritter, Heather M. Hayes, Shilpi Jain, Scott D. Pegan, Éric Bergeron, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-16 (2024)
Abstract Crimean-Congo hemorrhagic fever virus (CCHFV) can cause severe human disease and is considered a WHO priority pathogen due to the lack of efficacious vaccines and antivirals. A CCHF virus replicon particle (VRP) has previously shown protecti
Externí odkaz:
https://doaj.org/article/b8ba679dc1ff413493a3bbf4a114e16c
Autor:
Stephen R. Welch, Sarah C. Genzer, JoAnn D. Coleman-McCray, Jessica R. Harmon, Florine E.M. Scholte, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1390-1393 (2022)
Lassa fever (LF) is endemic to broad regions of West Africa. Infection with Lassa virus (LASV), the etiologic agent of LF, results in a spectrum of clinical signs in humans, including severe and lethal hemorrhagic disease. Person-to-person transmissi
Externí odkaz:
https://doaj.org/article/f6887cdc509741ae8a6c2d7048b6af7c
Autor:
Sarah C. Genzer, Timothy Flietstra, JoAnn D. Coleman-McCray, Cassandra Tansey, Stephen R. Welch, Jessica R. Spengler
Publikováno v:
Animals, Vol 13, Iss 5, p 895 (2023)
Guinea pigs are important animal models for human disease, and both outbred and inbred lines are utilized in biomedical research. The optimal maintenance of guinea pig colonies, commercially and in research settings, relies on robust informed breedin
Externí odkaz:
https://doaj.org/article/b0ea623737054d23b738be69b3c0cf63
Autor:
Stephen R. Welch, Jessica R. Spengler, Jessica R. Harmon, JoAnn D. Coleman-McCray, Florine E. M. Scholte, Sarah C. Genzer, Michael K. Lo, Joel M. Montgomery, Stuart T. Nichol, Christina F. Spiropoulou
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Defective interfering particles (DIs) contain a considerably smaller genome than the parental virus but retain replication competency. As DIs can directly or indirectly alter propagation kinetics of the parental virus, they offer a novel app
Externí odkaz:
https://doaj.org/article/7a8cdb374c104837925920d1abf39b77
Autor:
Catalina Forero, Jana M. Ritter, Josilene Nascimento Seixas, JoAnn D. Coleman-McCray, Marie Brake, Jillian A. Condrey, Cassandra Tansey, Stephen R. Welch, Sarah C. Genzer, Jessica R. Spengler
Publikováno v:
Pathogens, Vol 11, Iss 8, p 898 (2022)
Syrian hamsters are a key animal model of SARS-CoV-2 and other respiratory viruses and are useful for the evaluation of associated medical countermeasures. Delivery of an infectious agent or intervention to the respiratory tract mirrors natural route
Externí odkaz:
https://doaj.org/article/cd1c7b1c153e4adab016eb70acfb08e1
Autor:
Jessica R. Spengler, Stephen R. Welch, Sarah C. Genzer, JoAnn Coleman-McCray, Jessica R. Harmon, Stuart T. Nichol, Christina F. Spiropoulou
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 6, Pp 1238-1240 (2019)
Operating clinical analyzers within recommended parameters can be challenging during outbreak response. Using the Piccolo Xpress point-of-care blood chemistry analyzer on guinea pig blood, we found that values of many analytes are still readily compa
Externí odkaz:
https://doaj.org/article/7b601afbc2834c16a973da09188cd30a
Autor:
Stephen R. Welch, Jessica R. Spengler, Sarah C. Genzer, Payel Chatterjee, Mike Flint, Éric Bergeron, Joel M. Montgomery, Stuart T. Nichol, César G. Albariño, Christina F. Spiropoulou
Publikováno v:
Viruses, Vol 13, Iss 7, p 1255 (2021)
Lujo virus (LUJV), a highly pathogenic arenavirus, was first identified in 2008 in Zambia. To aid the identification of effective therapeutics for LUJV, we developed a recombinant reporter virus system, confirming reporter LUJV comparability with wil
Externí odkaz:
https://doaj.org/article/a5c5b74b8d64468b9220e208da5b46b7
Autor:
Jillian A. Condrey, Timothy Flietstra, Kaitlyn M. Nestor, Elizabeth L. Schlosser, JoAnn D. Coleman-McCray, Sarah C. Genzer, Stephen R. Welch, Jessica R. Spengler
Publikováno v:
Microorganisms, Vol 8, Iss 8, p 1127 (2020)
Inbred strain 13/N guinea pigs are used as small animal models for the study of hemorrhagic fever viruses. Coagulation abnormalities, including prolonged clotting times and bleeding, are characteristic of hemorrhagic fever in humans; patients often m
Externí odkaz:
https://doaj.org/article/892a54c1670f4e03ba0f9d6f1699e643
Autor:
Jessica R. Spengler, Stephen R. Welch, Jana M. Ritter, Jessica R. Harmon, JoAnn D. Coleman-McCray, Sarah C. Genzer, Josilene N. Seixas, Florine E.M. Scholte, Katherine A. Davies, Steven B. Bradfute, Joel M. Montgomery, Christina F. Spiropoulou
Publikováno v:
Antiviral research.
Development of lethal models of Ebola virus disease has been achieved by the serial passage of virus isolates from human cases in mice and guinea pigs. Use of mice infected with non-adapted virus has been limited due to the absence of overt clinical
Autor:
Stephen R. Welch, Jana M. Ritter, Amy J. Schuh, Sarah C. Genzer, Teresa E. Sorvillo, Jessica R. Harmon, JoAnn D. Coleman-McCray, Shilpi Jain, Punya Shrivastava-Ranjan, Josilene Nascimento Seixas, Lindsey B. Estetter, Pamela S. Fair, Jonathan S. Towner, Joel M. Montgomery, César G. Albariño, Christina F. Spiropoulou, Jessica R. Spengler
Publikováno v:
Antiviral research. 209
Human infection with Sosuga virus (SOSV), a recently discovered pathogenic paramyxovirus, has been reported in one individual to date. No animal models of disease are currently available for SOSV. Here, we describe initial characterization of experim