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pro vyhledávání: '"Sarah C. Cowles"'
Autor:
Allison Sheen, Yash Agarwal, Keith M. Cheah, Sarah C. Cowles, Jordan A. Stinson, Joseph R. Palmeri, Hadley D. Sikes, K. Dane Wittrup
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102766- (2023)
Catalase is an antioxidant enzyme that catalyzes the rapid conversion of hydrogen peroxide to water and oxygen. Use of catalase as a cancer therapeutic has been proposed to reduce oxidative stress and hypoxia in the tumor microenvironment, both activ
Externí odkaz:
https://doaj.org/article/bdc02fa1657a4226b9e43defbfbf2f40
Autor:
Sarah C. Cowles, Allison Sheen, Luciano Santollani, Emi A. Lutz, Brianna M. Lax, Joseph R. Palmeri, Gordon J. Freeman, K. Dane Wittrup
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Monoclonal antibodies targeting the programmed cell death protein 1 (PD-1) remain the most prevalent cancer immunotherapy both as a monotherapy and in combination with additional therapies. Despite the extensive success of anti-PD-1 monoclonal antibo
Externí odkaz:
https://doaj.org/article/a3566e931b5d476ea29616b10d00f10c
Autor:
Emi A. Lutz, Yash Agarwal, Noor Momin, Sarah C. Cowles, Joseph R. Palmeri, Ellen Duong, Vladlena Hornet, Allison Sheen, Brianna M. Lax, Adrienne M. Rothschilds, Darrell J. Irvine, Stefani Spranger, K. Dane Wittrup
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Effective antitumor immunity in mice requires activation of the type I interferon (IFN) response pathway. IFNα and IFNβ therapies have proven promising in humans, but suffer from limited efficacy and high toxicity. Intratumoral IFN retention amelio