Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sarah C. Bonema"'
Autor:
John B. Tucker, Sarah C. Bonema, Rebeca García-Varela, Ryan A. Denu, Yang Hu, Stephanie M. McGregor, Mark E. Burkard, Beth A. Weaver
Publikováno v:
Cancer Research Communications. 3:54-65
Chromosomal instability (CIN), the persistent reshuffling of chromosomes during mitosis, is a hallmark of human cancers that contributes to tumor heterogeneity and has been implicated in driving metastasis and altering responses to therapy. Though mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0792404a5ec4411c77187e0e624a431
https://doi.org/10.1158/2767-9764.crc-22-0302
https://doi.org/10.1158/2767-9764.crc-22-0302
Autor:
Beth A. Weaver, Mark E. Burkard, Stephanie M. McGregor, Yang Hu, Ryan A. Denu, Rebeca García-Varela, Sarah C. Bonema, John B. Tucker
Figure S5. Chromosomes that are misaligned at anaphase onset are rapidly incorporated into the main DNA masses during anaphase A. A-B. Timelapse analysis of T47D (A) and Cal51 (B) breast cancer cells with endogenously labeled histone H2B and a-tubuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6daca971fc61414ef241fbc2067d763c
https://doi.org/10.1158/2767-9764.22546121
https://doi.org/10.1158/2767-9764.22546121
Autor:
Beth A. Weaver, Mark E. Burkard, Stephanie M. McGregor, Yang Hu, Ryan A. Denu, Rebeca García-Varela, Sarah C. Bonema, John B. Tucker
Figure S3. Lagging chromosomes in breast cancer are primarily mitotic in origin. A-B. Images of lagging chromosomes lacking a centromere, which are likely to occur due to premitotic defects (A) or containing their centromere, which are likely to aris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5105bd55da064aef48ab8c56fbb28bc9
https://doi.org/10.1158/2767-9764.22546127.v1
https://doi.org/10.1158/2767-9764.22546127.v1
Table TS2 from Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer
Autor:
Beth A. Weaver, Mark E. Burkard, Stephanie M. McGregor, Yang Hu, Ryan A. Denu, Rebeca García-Varela, Sarah C. Bonema, John B. Tucker
Table S2. Patient characteristics of matched primary and metastatic cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e34ab8e26fb838805f0d447a641c43
https://doi.org/10.1158/2767-9764.22546100.v1
https://doi.org/10.1158/2767-9764.22546100.v1
Autor:
Beth A. Weaver, Mark E. Burkard, Stephanie M. McGregor, Yang Hu, Ryan A. Denu, Rebeca García-Varela, Sarah C. Bonema, John B. Tucker
Figure S2. Breast tumor subtypes show similar rates of mitotic defects. A. Triple Negative (TN) and HER2+ tumors show higher CIN as assessed by 6-chromosome interphase FISH (see Methods) than hormone (ER and/or PR) receptor positive (HR+) tumors. n =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c003c80953c4779a7d8aedf9387b743
https://doi.org/10.1158/2767-9764.22546130.v1
https://doi.org/10.1158/2767-9764.22546130.v1
Table TS1 from Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer
Autor:
Beth A. Weaver, Mark E. Burkard, Stephanie M. McGregor, Yang Hu, Ryan A. Denu, Rebeca García-Varela, Sarah C. Bonema, John B. Tucker
Table S1. Patient characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5893923331a1aa369e7a6487e168cb73
https://doi.org/10.1158/2767-9764.22546103
https://doi.org/10.1158/2767-9764.22546103
Autor:
Beth A. Weaver, Mark E. Burkard, Stephanie M. McGregor, Yang Hu, Ryan A. Denu, Rebeca García-Varela, Sarah C. Bonema, John B. Tucker
Figure S4. Misaligned chromosomes are the predominant mitotic error in breast cancer organoids. A. Biopsies of primary breast cancer were grown in Matrigel suspension into patient-derived organoids (PDOs), which were prepared for immunofluorescence a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bcd4b6b1125586cc9fbc791b5742a2
https://doi.org/10.1158/2767-9764.22546124.v1
https://doi.org/10.1158/2767-9764.22546124.v1
Autor:
Beth A. Weaver, Mark E. Burkard, Stephanie M. McGregor, Yang Hu, Ryan A. Denu, Rebeca García-Varela, Sarah C. Bonema, John B. Tucker
Misaligned chromosome that persists through anaphase onset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0bf2dffab7cbac76717756bcd40d32
https://doi.org/10.1158/2767-9764.22546115
https://doi.org/10.1158/2767-9764.22546115
Autor:
Beth A. Weaver, Mark E. Burkard, Stephanie M. McGregor, Yang Hu, Ryan A. Denu, Rebeca García-Varela, Sarah C. Bonema, John B. Tucker
Figure S1. Pipeline to assess CIN in primary breast cancer. A. A tissue microarray containing 377 breast cancer and 17 normal breast samples was evaluated for proliferation by Ki67 and CIN based on 6 chromosome FISH (39). H&E stained sections for cas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd412ec78b33ce0785ff8a8ecd39e9f
https://doi.org/10.1158/2767-9764.22546133
https://doi.org/10.1158/2767-9764.22546133
Autor:
Beth A. Weaver, Mark E. Burkard, Stephanie M. McGregor, Yang Hu, Ryan A. Denu, Rebeca García-Varela, Sarah C. Bonema, John B. Tucker
Chromosomal instability (CIN), the persistent reshuffling of chromosomes during mitosis, is a hallmark of human cancers that contributes to tumor heterogeneity and has been implicated in driving metastasis and altering responses to therapy. Though mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6a6a0d61550085843e1f30d36336e6
https://doi.org/10.1158/2767-9764.c.6551099.v1
https://doi.org/10.1158/2767-9764.c.6551099.v1