Výsledky vyhledávání - "Sarah C. Bodary"

Effects of kistrin on bone resorption in vitro and serum calcium in vivo

Autor: Kathleen King, Subhash C. Kukreja, Robert M. Pitti, Sarah C. Bodary, Mark S. Dennis, Robert A. Lazarus, Mark Siegel, James J. D'Anza, R. Glenn Hammonds

Publikováno v: Europe PubMed Central

In many cell systems, cell-cell and cell-matrix interactions are mediated by integrins, a family of cell surface heterodimeric glycoprotein receptors. Osteoclast integrins may play a role in the process of bone resorption. Osteoclasts express the alp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6c847c506d0ecd47b24406d46316e2
https://doi.org/10.1002/jbmr.5650090313

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Blockade of CD11a by Efalizumab in Psoriasis Patients Induces a Unique State of T-Cell Hyporesponsiveness

Autor: Yulia Vugmeyster, Francesca Chamian, Edmund Lee, Toyoko Kikuchi, Wolfgang Dummer, Kathy Howell, Michelle A. Lowes, Emma Guttman-Yassky, James G. Krueger, Sarah C. Bodary, Brisdell Hunte, Patricia Gilleaudeau, Mark Kagen

Publikováno v: Journal of Investigative Dermatology. 128(5):1182-1191

Efalizumab (anti-CD11a) interferes with LFA-1/ICAM-1 binding and inhibits several key steps in psoriasis pathogenesis. This study characterizes the effects of efalizumab on T-cell activation responses and expression of surface markers on human circul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3652113ef59e5ff50331fef60529df1

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Elevated Flk1 (Vascular Endothelial Growth Factor Receptor 2) Signaling Mediates Enhanced Angiogenesis in β3-Integrin–Deficient Mice

Autor: Stephen D. Robinson, Tobi Nagel, Julie C. Lively, Sarah C. Bodary, Andrew R. Reynolds, Louise E. Reynolds, Daniel J. Hicklin, Kairbaan Hodivala-Dilke

Publikováno v: Cancer Research. 64:8643-8650

Tumor growth, tumor angiogenesis, and vascular endothelial growth factor (VEGF)–specific angiogenesis are all enhanced in β3-integrin–null mice. Furthermore, endothelial cells isolated from β3-null mice show elevated levels of Flk1 (VEGF recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94402dcdbe241d923df37f1dffe532af
https://doi.org/10.1158/0008-5472.can-04-2760

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Efalizumab (anti-CD11a)-induced increase in peripheral blood leukocytes in psoriasis patients is preferentially mediated by altered trafficking of memory CD8+ T cells into lesional skin*1

Autor: Sarah C. Bodary, James G. Krueger, Patricia Gilleaudeau, Yulia Vugmeyster, Michelle A. Lowes, Francesca Chamian, Edmund Lee, Kathy Howell, Toyoko Kikuchi, Wolfgang Dummer, Mark Kagen

Publikováno v: Clinical Immunology. 113:38-46

Therapeutic administration of efalizumab, a humanized antibody to CD11a, induces a marked but reversible increase of peripheral lymphocytes in psoriasis patients. In this study, 13 patients were treated with 12 weekly subcutaneous doses (2 mg/kg/week

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a8e48c96e795c3d6a3fd1add9677ce5
https://doi.org/10.1016/j.clim.2004.06.001

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ANGPTL3 Stimulates Endothelial Cell Adhesion and Migration via Integrin αvβ3 and Induces Blood Vessel Formation in Vivo

Autor: Ming-Hong Xie, Maria Teresa Pisabarro, Joe Kowalski, Phil Hass, Daniel Eric Sherman, Austin L. Gurney, Maureen Beresini, Xiao Huan Liang, Sarah C. Bodary, Napoleone Ferrara, Gieri Camenisch, Mark Nagel, Hans-Peter Gerber, Kevin R Clark

Publikováno v: Journal of Biological Chemistry. 277:17281-17290

The angiopoietin family of secreted factors is functionally defined by the C-terminal fibrinogen (FBN)-like domain, which mediates binding to the Tie2 receptor and thereby facilitates a cascade of events ultimately regulating blood vessel formation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a973045d7b8435cdaf2a7c612de2e891
https://doi.org/10.1074/jbc.m109768200

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αvβ3 Antagonists Based on a Central Thiophene Scaffold

Autor: Thomas R. Gadek, Denis Carniato, Martine Gaillard, Marielle Auberval, Jochen Knolle, Roland Baron, Jean-Marie Ruxer, Karl-Heinz Scheunemann, Jean-Francois Gourvest, Gerhard Breipohl, Hans Ulrich Stilz, Volkmar Wehner, Sarah C. Bodary, Bernard Doucet, David William Will, Anusch Peyman

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:2011-2015

A series of novel, highly potent αvβ3 antagonists based on a thiophene scaffold and containing an acylguanidine as an Arg-mimetic is described. A number of structural features, such as cyclic versus open guanidine and a variety of lipophilic side c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f136522c3481063c64ca763b3d2c2677
https://doi.org/10.1016/s0960-894x(01)00357-2

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RGD Mimetics containing a central hydantoin scaffold: α V β 3 vs α IIb β 3 selectivity requirements

Autor: Jochen Knolle, Denis Carniato, Hans Ulrich Stilz, Jean-Marie Ruxer, Karl-Heinz Scheunemann, Anusch Peyman, Gerhard Breipohl, Thomas R. Gadek, Volkmar Wehner, Jean-Francois Gourvest, Sarah C. Bodary

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:179-182

The synthesis of a series of RGD mimetic α V β 3 antagonists containing a hydantoin scaffold is shown. The results demonstrate some of the structural requirements for the design of selective α V β 3 antagonists (vs α IIb β 3 ) in terms of the A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a82fbf3e90d49c6f95049e97489c9e13
https://doi.org/10.1016/s0960-894x(99)00661-7

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Kistrin Inhibits Human Smooth Muscle Cell Interaction with Fibrin

Autor: Yuji Ikari, Karen O. Yee, Stephen M. Schwartz, Sarah C. Bodary

Publikováno v: Thrombosis Research. 97:39-50

Because of the lack of function-blocking anti-integrin antibodies that react with nonprimate species, the study of the role of integrins in in vivo animal models of atherosclerosis has been limited. In contrast, peptides or small molecules have shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9849be389331d549fc9fef4bcf5454b
https://doi.org/10.1016/s0049-3848(99)00159-0

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Characterization of a candidate Borrelia burgdorferi beta3-chain integrin ligand identified using a phage display library

Autor: Wambui Chege, Jenifer Coburn, Sarah C. Bodary, John M. Leong, Loranne Magoun

Publikováno v: Molecular Microbiology. 34:926-940

The spirochaetal agents of Lyme disease, Borrelia burgdorferi (sensu lato) bind to integrins alphaIIbbeta3, alphavbeta3 and alpha5beta1 in purified form and on the surfaces of human cells. Using a phage display library of B. burgdorferi (sensu strict

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b30849598ccb4a87b50982a5a81fdf
https://doi.org/10.1046/j.1365-2958.1999.01654.x

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A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid (RGD) motif preferentially binds human integrins α v β 3 and α IIb β 3

Autor: Sarah Renish, Jenifer Coburn, Kathryn E. Stockbauer, Mengyao Liu, Eugene H. Burns, Siddeswar Gubba, Sarah C. Bodary, Loranne Magoun, James M. Musser, John M. Leong, Elizabeth Baker, Xi Pan

Publikováno v: Proceedings of the National Academy of Sciences. 96:242-247

The human pathogenic bacterium group A Streptococcus produces an extracellular cysteine protease [streptococcal pyrogenic exotoxin B (SpeB)] that is a critical virulence factor for invasive disease episodes. Sequence analysis of the speB gene from 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::debd68f8178297cbf71076dbc224585c
https://doi.org/10.1073/pnas.96.1.242

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