Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sarah C. Abbot"'
Autor:
Taygerly Joshua Paul Gergely, Eun Kyung Lee, Mcintosh Joel, Sarah C. Abbot, Jaehyeon Park, Sonal Rajyaguru, Yun-Chou Tan, Shalini Anand, Francisco Xavier Talamas, Sophie Le Pogam, Remy Lemoine, David S. Carter, Petra Inbar, Jun Chen, Leanna R. Staben, Armando G. Villaseñor, Javier de Vicente, Isabel Najera, Ryan Craig Schoenfeld, Leyi Gong, Seth F. Harris, Paul Weller, Sharada Shenvi Labadie, Ken A. Brameld, Aruna Railkar, Sangi Michael, Amy Fung, Jim Li, Vincent Leveque, Dana Davis
Publikováno v:
Journal of Medicinal Chemistry. 57:1914-1931
In the past few years, there have been many advances in the efforts to cure patients with hepatitis C virus (HCV). The ultimate goal of these efforts is to develop a combination therapy consisting of only direct-antiviral agents (DAAs). In this paper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8b3c89c500a0233782f42b5f71c4d4
https://doi.org/10.1021/jm401329s
https://doi.org/10.1021/jm401329s
Autor:
Mcintosh Joel, Andreas Kuglstatter, Paul Weller, Sarah C. Abbot, David C. Swinney, Brad Loe, Tobias Gabriel, Roland J. Billedeau, Martin Stahl, Hasim Zecic, Nidhi Arora, Eva Papp, Humberto Bartolome Arzeno, Brian Wong, Allassan Abubakari, Nolan James Dewdney, David Michael Goldstein, Man-Ling Sung, Rebecca T Suttman, Michael Soth, Jaehyeon Park, Kieran Durkin, Fujun Li, Manjiri Ghate, Kristen Lynn Mccaleb, Sandra Frauchiger, Ronald J. Hill
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3452-3456
Learnings from previous Roche p38-selective inhibitors were applied to a new fragment hit, which was optimized to a potent, exquisitely selective preclinical lead with a good pharmacokinetic profile.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8eb5a3a44a865221a520c55232f9f7
https://doi.org/10.1016/j.bmcl.2011.03.098
https://doi.org/10.1016/j.bmcl.2011.03.098
Autor:
Keith A. M. Walker, Roland J. Billedeau, Sarah C. Abbot, Christine S. Chan, Sharon M. Dankwardt, Harold E. Van Wart, Linda K Lawley, Robert L. Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2513-2516
A solid-phase approach to the rapid synthesis of di- and tripeptide-like hydroxamic acids is presented. These compounds are shown to be potent inhibitors of procollagen C-proteinase (PCP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758e3d39335e04fc89bf13213053077b
https://doi.org/10.1016/s0960-894x(00)00525-4
https://doi.org/10.1016/s0960-894x(00)00525-4
Autor:
Sarah C. Abbot, Richard P. Johnson, Mary M. Kirchhoff, Manisha Nigam, Matthew S. Platz, John P. Toscano, Brett M. Showalter
Publikováno v:
Journal of the American Chemical Society. 120:8055-8059
The curved plots of (carbene adduct)/(carbene-rearrangement product) versus carbene trapping agent, tetramethylene [TME], reported with benzylchlorodiazirine 1 have been reproduced. However, with the use of a non-nitrogenous precursor, plots of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ee1e6b561fbd97c4177c9efcb41dcf4
https://doi.org/10.1021/ja980251w
https://doi.org/10.1021/ja980251w
Autor:
Richard P. Johnson, Igor Likhotvorik, Matthew S. Platz, Mary M. Kirchhoff, Sarah C. Abbot, Marc Robert
Publikováno v:
The Journal of Physical Chemistry A. 102:1507-1513
Previously we have studied the photochemistry of alkylchlorodiazirines using laser flash photolysis methods and the pyridine ylide technique (White et al. J. Org. Chem. 1992, 17, 2841). The yield o...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d8d9a0e9625ed96f29c48a15a2fb798
https://doi.org/10.1021/jp972464y
https://doi.org/10.1021/jp972464y
Autor:
John P. Toscano, Matthew S. Platz, Marc Robert, Mary M. Kirchhoff, Sarah C. Abbot, Richard P. Johnson
Publikováno v:
The Journal of Physical Chemistry. 100:18426-18430
Laser flash photolysis (308 nm) of endo-7-chlorodibenzo[a,c]bicyclo[4.1.0]heptane produces phenanthrene and chlorocarbene, which can be trapped with pyridine to form an ylide. The ylide absorbs strongly at 374 nm, and its lifetime is many tens of mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fabe28cb646f97fed8e9a9b85ebbe99
https://doi.org/10.1021/jp962333h
https://doi.org/10.1021/jp962333h
Autor:
Richard P. Johnson, Manisha Nigam, Matthew S. Platz, John P. Toscano, Brett M. Showalter, Mary M. Kirchhoff, Sarah C. Abbot
Publikováno v:
ChemInform. 29
The curved plots of (carbene adduct)/(carbene-rearrangement product) versus carbene trapping agent, tetramethylene [TME], reported with benzylchlorodiazirine 1 have been reproduced. However, with the use of a non-nitrogenous precursor, plots of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::305f2066c041e62a2890dd513032da2c
https://doi.org/10.1002/chin.199847062
https://doi.org/10.1002/chin.199847062
Autor:
Teresa Alejandra Trejo-Martin, Roland J. Billedeau, Hasim Zecic, Nolan James Dewdney, Michael Soth, Tobias Gabriel, David Michael Goldstein, Kristen Lynn Mccaleb, Sarah C. Abbot
Publikováno v:
ChemInform. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::678907f8a87bf8fade9ab79cb7f743de
https://doi.org/10.1002/chin.201013129
https://doi.org/10.1002/chin.201013129
Autor:
Sarah C. Abbot, Christine S. Chan, Sharon M. Dankwardt, Chris Allen Broka, Keith A. M. Walker, Harold E. Van Wart, Eric B. Springman, Robert L. Martin
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(8)
Optimization of the amino acid side chain and the N-alkyl group of the sulfonamide of amino acid derived sulfonamide hydroxamates is discussed. The solid-phase synthesis of these potent inhibitors of procollagen C-proteinase (PCP) is presented. In ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d114f4b680f08370ec702afb8776563
https://pubmed.ncbi.nlm.nih.gov/11934595
https://pubmed.ncbi.nlm.nih.gov/11934595
Autor:
Nolan James Dewdney, Teresa Alejandra Trejo-Martin, Roland J. Billedeau, Michael Soth, Hasim Zecic, Sarah C. Abbot, Tobias Gabriel, David Michael Goldstein, Kristen Lynn Mccaleb
Publikováno v:
HETEROCYCLES. 78:2811
The synthesis of pyrazolo-pyridine, pyrimidine, pyrazine and pyridazine heterocycles is described. In addition, we report the utilization of 2,4-difluorophenoxide as a leaving group, to facilitate formation of the desired pyrazole adducts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6b51e4d50970007f3559152dc4a0cba
https://doi.org/10.3987/com-09-11808
https://doi.org/10.3987/com-09-11808