Výsledky vyhledávání - "Sarah C Stanhope"

Akademický článek

Proteome-wide quantitative analysis of redox cysteine availability in the Drosophila melanogaster eye reveals oxidation of phototransduction machinery during blue light exposure and age

Autor: Sarah C. Stanhope, Tal Brandwine-Shemmer, Hannah R. Blum, Emma H. Doud, Amber Jannasch, Amber L. Mosley, Baruch Minke, Vikki M. Weake

Publikováno v: Redox Biology, Vol 63, Iss , Pp 102723- (2023)

The retina is one of the highest oxygen-consuming tissues because visual transduction and light signaling processes require large amounts of ATP. Thus, because of the high energy demand, oxygen-rich environment, and tissue transparency, the eye is su

Externí odkaz: https://doaj.org/article/a38adced786e401d80ce4ce7f9ef9c3c

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Akademický článek

The Clock:Cycle complex is a major transcriptional regulator of Drosophila photoreceptors that protects the eye from retinal degeneration and oxidative stress.

Autor: Juan Jauregui-Lozano, Hana Hall, Sarah C Stanhope, Kimaya Bakhle, Makayla M Marlin, Vikki M Weake

Publikováno v: PLoS Genetics, Vol 18, Iss 1, p e1010021 (2022)

The aging eye experiences physiological changes that include decreased visual function and increased risk of retinal degeneration. Although there are transcriptomic signatures in the aging retina that correlate with these physiological changes, the g

Externí odkaz: https://doaj.org/article/fd9ec7e049024ad6a37e6845d961e788

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Targeted RNAi screen identifies transcriptional mechanisms that prevent premature degeneration of adult photoreceptors

Autor: Spencer E. Escobedo, Sarah E. McGovern, Juan P. Jauregui-Lozano, Sarah C. Stanhope, Paul Anik, Kratika Singhal, Ryan DeBernardis, Vikki M. Weake

Publikováno v: Frontiers in Epigenetics and Epigenomics. 1

Aging is associated with a decline in visual function and increased prevalence of ocular disease, correlating with changes in the transcriptome and epigenome of cells in the eye. Here, we sought to identify the transcriptional mechanisms that are nec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae7dce2bfa67717ba84a4070974b4782
https://doi.org/10.3389/freae.2023.1187980

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