Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sarah C Milian"'
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175069 (2017)
Glucose-stimulated insulin secretion (GSIS) relies on β-cell Ca2+ influx, which is modulated by the two-pore-domain K+ (K2P) channel, TALK-1. A gain-of-function polymorphism in KCNK16, the gene encoding TALK-1, increases risk for developing type-2 d
Externí odkaz:
https://doaj.org/article/0260e18cbfe5473eaddeba30916880f4
Autor:
Nicholas C. Vierra, Matthew T. Dickerson, Kelli L. Jordan, Prasanna K. Dadi, Ketaki A. Kadare, Molly K. Altman, Sarah C. Milian, David A. Jacobson
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 84-97 (2018)
Objective: Single-cell RNA sequencing studies have revealed that the type-2 diabetes associated two-pore domain K+ (K2P) channel TALK-1 is abundantly expressed in somatostatin-secreting δ-cells. However, a physiological role for TALK-1 in δ-cells r
Externí odkaz:
https://doaj.org/article/1d9f371e00d5410b87f2af7f170d89cf
Autor:
Kelli L. Jordan, Sarah C. Milian, David A. Jacobson, Molly K. Altman, Avery M. Bogart, Prasanna K. Dadi, Matthew T. Dickerson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Cytokines present during low-grade inflammation contribute to β-cell dysfunction and diabetes. Cytokine signaling disrupts β-cell glucose-stimulated Ca2+ influx (GSCI) and endoplasmic reticulum (ER) Ca2+ ([Ca2+]ER) handling, leading to diminished g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0855bcc1398021a73ab630a1c3ba55
https://doi.org/10.1038/s41598-018-19600-x
https://doi.org/10.1038/s41598-018-19600-x
Autor:
Matthew T, Dickerson, Avery M, Bogart, Molly K, Altman, Sarah C, Milian, Kelli L, Jordan, Prasanna K, Dadi, David A, Jacobson
Publikováno v:
Scientific Reports
Cytokines present during low-grade inflammation contribute to β-cell dysfunction and diabetes. Cytokine signaling disrupts β-cell glucose-stimulated Ca2+ influx (GSCI) and endoplasmic reticulum (ER) Ca2+ ([Ca2+]ER) handling, leading to diminished g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4113e0b772f6906224e2e74eff9b82c
https://pubmed.ncbi.nlm.nih.gov/29348619
https://pubmed.ncbi.nlm.nih.gov/29348619
Autor:
Matthew T. Dickerson, Sarah C. Milian, Prasanna K. Dadi, Patrick Gilon, David A. Jacobson, Kelli L. Jordan, Nicholas C. Vierra
Ca2+ handling by the endoplasmic reticulum (ER) serves critical roles controlling pancreatic β-cell function and becomes perturbed during the pathogenesis of diabetes. ER Ca2+ homeostasis is determined by ion movements across the ER membrane, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed18d8a1deed89b3d288476d7a1246b4
https://europepmc.org/articles/PMC5672804/
https://europepmc.org/articles/PMC5672804/
Publikováno v:
Biophysical Journal. 112:484a-485a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74eb244a3d5198d97a7ab0f8b5e956e7
https://doi.org/10.1016/j.bpj.2016.11.2622
https://doi.org/10.1016/j.bpj.2016.11.2622
Autor:
Nicholas C. Vierra, Prasanna K. Dadi, David A. Jacobson, Sarah C. Milian, Matthew T. Dickerson
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175069 (2017)
PLoS ONE
PLoS ONE
Glucose-stimulated insulin secretion (GSIS) relies on β-cell Ca2+ influx, which is modulated by the two-pore-domain K+ (K2P) channel, TALK-1. A gain-of-function polymorphism in KCNK16, the gene encoding TALK-1, increases risk for developing type-2 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f0315534120355a18787066b31a792
https://doi.org/10.1371/journal.pone.0175069
https://doi.org/10.1371/journal.pone.0175069