Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sarah Brendle"'
Autor:
Ria T. Caringal, John M. Hickey, Nitya Sharma, Kaushal Jerajani, Oluwadara Bewaji, Sarah Brendle, Neil Christensen, Saurabh Batwal, Mustafa Mahedvi, Harish Rao, Vikas Dogar, Rahul Chandrasekharan, Umesh Shaligram, Sangeeta B. Joshi, David B. Volkin
Publikováno v:
Vaccines, Vol 12, Iss 6, p 580 (2024)
During the multi-dose formulation development of recombinant vaccine candidates, protein antigens can be destabilized by antimicrobial preservatives (APs). The degradation mechanisms are often poorly understood since available analytical tools are li
Externí odkaz:
https://doaj.org/article/bba59822ec044a848e29864c5e328c6a
Autor:
Sarah Brendle, Nancy Cladel, Karla Balogh, Samina Alam, Neil Christensen, Craig Meyers, Jiafen Hu
Publikováno v:
Vaccines, Vol 9, Iss 12, p 1501 (2021)
Human papillomavirus (HPV) 16 capsids have been chosen as a DNA delivery vehicle in many studies. Our preliminary studies suggest that HPV58 capsids could be better vehicles than HPV16 capsids to deliver encapsidated DNA in vitro and in vivo. In the
Externí odkaz:
https://doaj.org/article/a7ab6ba1f3484d4088f43c4381a6e2f6
Autor:
Sarah Brendle, Jingwei J. Li, Nancy M. Cladel, Debra A. Shearer, Lynn R. Budgeon, Karla K. Balogh, Hannah Atkins, Marina Costa-Fujishima, Paul Lopez, Neil D. Christensen, John Doorbar, Thomas T. Murooka, Jiafen Hu
Publikováno v:
Viruses, Vol 13, Iss 9, p 1824 (2021)
Papillomavirus L1 and L2, the major and minor capsid proteins, play significant roles in viral assembly, entry, and propagation. In the current study, we investigate the impact of L1 and L2 on viral life cycle and tumor growth with a newly establishe
Externí odkaz:
https://doaj.org/article/1a3b57b1851d435f82214a82c7040daf
Autor:
Nitya Sharma, Kaushal Jerajani, Ying Wan, Ozan S. Kumru, Swathi R. Pullagurla, Oluwadara Ogun, Shweta Mapari, Sarah Brendle, Neil D. Christensen, Saurabh Batwal, Mustafa Mahedvi, Harish Rao, Vikas Dogar, Rahul Chandrasekharan, Umesh Shaligram, David B. Volkin, Sangeeta B. Joshi
Publikováno v:
Journal of pharmaceutical sciences.
This work describes Part 2 of multi-dose formulation development of a Human Papillomavirus (HPV) Virus-Like Particles (VLPs) containing vaccine (see Part 1 in companion paper). Storage stability studies with candidate multi-dose formulations containi
Autor:
Kaushal Jerajani, Ying Wan, Ozan S. Kumru, Swathi R. Pullagurla, Prashant Kumar, Nitya Sharma, Oluwadara Ogun, Shweta Mapari, Sarah Brendle, Neil D. Christensen, Saurabh Batwal, Mustafa Mahedvi, Harish Rao, Vikas Dogar, Rahul Chandrasekharan, Umesh Shaligram, Sangeeta B. Joshi, David B. Volkin
Publikováno v:
Journal of pharmaceutical sciences.
The development of multi-dose, subunit vaccine formulations can be challenging since antimicrobial preservatives (APs) often destabilize protein antigens. In this work, we evaluated Human Papillomavirus (HPV) Virus-Like Particles (VLPs) to determine
Autor:
Kaushal Jerajani, Ying Wan, John M. Hickey, Ozan S. Kumru, Nitya Sharma, Swathi R. Pullagurla, Oluwadara Ogun, Shweta Mapari, Neal Whitaker, Sarah Brendle, Neil D. Christensen, Saurabh Batwal, Mustafa Mahedvi, Harish Rao, Vikas Dogar, Rahul Chandrasekharan, Umesh Shaligram, Sangeeta B. Joshi, David B. Volkin
Publikováno v:
Journal of pharmaceutical sciences. 111(11)
Introducing multi-dose formulations of Human Papillomavirus (HPV) vaccines will reduce costs and enable improved global vaccine coverage, especially in low- and middle-income countries. This work describes the development of key analytical methods la