Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alstrom syndrome

Autor: R Cramb, Richard B Paisey, Robert K. Semple, Jonathan Hazlehurst, Shaun Bolton, P N Newsome, Rachel K Crowley, Maria Round, Tarekegn Geberhiwot, Laura Gathercole, Sarah Boocock, Jeremy W. Tomlinson, Rachel M. Brown, Matthew J. Armstrong, Michael W O'Reilly

Publikováno v: Gathercole, L L, Hazlehurst, J M, Armstrong, M J, Crowley, R, Boocock, S, O'Reilly, M W, Round, M, Brown, R, Bolton, S, Cramb, R, Newsome, P N, Semple, R K, Paisey, R, Tomlinson, J W & Geberhiwot, T 2016, ' Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alström syndrome ', Liver International, vol. 36, no. 11, pp. 1704-1712 . https://doi.org/10.1111/liv.13163

Background and Aims: Alström syndrome (AS) is a recessive monogenic syndrome characterized by obesity, extreme insulin resistance and multi-organ fibrosis. Despite phenotypically being high risk of non-alcoholic fatty liver disease (NAFLD), there is

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