Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Sarah Bonte"'
1
Akademický článek
The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation
Autor: Melissa Pille, John Avila, Guillem Sanchez Sanchez, Glenn Goetgeluk, Stijn De Munter, Hanne Jansen, Lore Billiet, Karin Weening, Haipeng Xue, Sarah Bonte, Joline Ingels, Laurenz De Cock, Eva Pascal, Lucas Deseins, Tessa Kerre, Tom Taghon, Georges Leclercq, David Vermijlen, Brian Davis, Bart Vandekerckhove
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
The Wiskott–Aldrich syndrome (WAS) is an X-linked primary immune deficiency caused by a mutation in the WAS gene. This leads to altered or absent WAS protein (WASp) expression and function resulting in thrombocytopenia, eczema, recurrent infections
Externí odkaz: https://doaj.org/article/8e328ea3407848819b605b95f452cf7f
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2
Akademický článek
In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality
Autor: Sarah Bonte, Stijn de Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz de Cock, Karin Weening, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)
T cell receptor (TCR)-redirected T cells target intracellular antigens such as Wilms’ tumor 1 (WT1), a tumor-associated antigen overexpressed in several malignancies, including acute myeloid leukemia (AML). For both chimeric antigen receptor (CAR)-
Externí odkaz: https://doaj.org/article/b8d37350b35e4c9e9ca7c2af1a96b344
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3
Akademický článek
T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources
Autor: Sarah Bonte, Stijn De Munter, Glenn Goetgeluk, Joline Ingels, Melissa Pille, Lore Billiet, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
Publikováno v: OncoImmunology, Vol 9, Iss 1 (2020)
Chimeric antigen receptor (CAR) T-cells have shown great promise in the treatment of B-cell malignancies. For acute myeloid leukemia (AML), however, the optimal target surface antigen has yet to be discovered. Alternatively, T-cell receptor (TCR)-red
Externí odkaz: https://doaj.org/article/8a9e6e8dd9154340bb2f53f8c0e0027b
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4
Akademický článek
Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities
Autor: Yasmine Van Caeneghem, Stijn De Munter, Paola Tieppo, Glenn Goetgeluk, Karin Weening, Greet Verstichel, Sarah Bonte, Tom Taghon, Georges Leclercq, Tessa Kerre, Reno Debets, David Vermijlen, Hinrich Abken, Bart Vandekerckhove
Publikováno v: OncoImmunology, Vol 6, Iss 3 (2017)
Recent clinical studies indicate that adoptive T-cell therapy and especially chimeric antigen receptor (CAR) T-cell therapy is a very potent and potentially curative treatment for B-lineage hematologic malignancies. Currently, autologous peripheral b
Externí odkaz: https://doaj.org/article/20e75ad2cb564c7c8a949cd5e8b92798
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7
In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality
Autor: Stijn De Munter, Tessa Kerre, Lore Billiet, Hanne Jansen, Georges Leclercq, Joline Ingels, Sarah Bonte, Karin Weening, Glenn Goetgeluk, Tom Taghon, Bart Vandekerckhove, Laurenz De Cock, Melissa Pille
Publikováno v: Oncoimmunology
article-version (VoR) Version of Record
OncoImmunology, Vol 10, Iss 1 (2021)
ONCOIMMUNOLOGY
T cell receptor (TCR)-redirected T cells target intracellular antigens such as Wilms’ tumor 1 (WT1), a tumor-associated antigen overexpressed in several malignancies, including acute myeloid leukemia (AML). For both chimeric antigen receptor (CAR)-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58a17d2cada7740ea26397f1989d7bd
http://europepmc.org/articles/PMC8312599
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9
Human Thymic CD10
Autor: Lore, Billiet, Glenn, Goetgeluk, Sarah, Bonte, Stijn, De Munter, Laurenz, De Cock, Melissa, Pille, Joline, Ingels, Hanne, Jansen, Karin, Weening, Filip, Van Nieuwerburgh, Tessa, Kerre, Tom, Taghon, Georges, Leclercq, Bart, Vandekerckhove
Publikováno v: International Journal of Molecular Sciences
Human thymic CD8αα+ CD10+ PD-1+ αβ T cells selected through early agonist selection have been proposed as the putative thymic precursors of the human CD8αα+ intestinal intraepithelial lymphocytes (IELs). However, the progeny of these thymic pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59209028f75a052c5a7d44c9e1491bf4
https://pubmed.ncbi.nlm.nih.gov/33233766
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10
T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources
Autor: Tessa Kerre, Joline Ingels, Tom Taghon, Glenn Goetgeluk, Stijn De Munter, Sarah Bonte, Melissa Pille, Lore Billiet, Bart Vandekerckhove, Georges Leclercq
Publikováno v: ONCOIMMUNOLOGY
OncoImmunology, Vol 9, Iss 1 (2020)
Chimeric antigen receptor (CAR) T-cells have shown great promise in the treatment of B-cell malignancies. For acute myeloid leukemia (AML), however, the optimal target surface antigen has yet to be discovered. Alternatively, T-cell receptor (TCR)-red
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33cb1bb5fe2ce20e832bfa22a0d80b6
https://doi.org/10.1080/2162402x.2020.1727078
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