Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sarah B, Crist"'
Autor:
Sarah B. Crist, Karim Azzag, James Kiley, Ilsa Coleman, Alessandro Magli, Rita C. R. Perlingeiro
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract Pluripotent stem cell (PSC)-based cell therapy is an attractive option for the treatment of multiple human disorders, including muscular dystrophies. While in vitro differentiating PSCs can generate large numbers of human lineage-specific ti
Externí odkaz:
https://doaj.org/article/3ac59d76d3d74db5b598651beb2c7b74
Publikováno v:
Cells, Vol 13, Iss 11, p 972 (2024)
Mutations in the DMD gene cause fatal Duchenne Muscular Dystrophy (DMD). An attractive therapeutic approach is autologous cell transplantation utilizing myogenic progenitors derived from induced pluripotent stem cells (iPSCs). Given that a significan
Externí odkaz:
https://doaj.org/article/8c4239b814e34c778036e237865d9511
Establishment of Skeletal Myogenic Progenitors from Non-Human Primate Induced Pluripotent Stem Cells
Autor:
June Baik, Carolina Ortiz-Cordero, Alessandro Magli, Karim Azzag, Sarah B. Crist, Aline Yamashita, James Kiley, Sridhar Selvaraj, Ricardo Mondragon-Gonzalez, Elizabeth Perrin, John P. Maufort, Jody L. Janecek, Rachael M. Lee, Laura Hocum Stone, Parthasarathy Rangarajan, Sabarinathan Ramachandran, Melanie L. Graham, Rita C. R. Perlingeiro
Publikováno v:
Cells, Vol 12, Iss 8, p 1147 (2023)
Pluripotent stem (PS) cells enable the scalable production of tissue-specific derivatives with therapeutic potential for various clinical applications, including muscular dystrophies. Given the similarity to human counterparts, the non-human primate
Externí odkaz:
https://doaj.org/article/ca90a32d1b4844d29800015a149982ef
Autor:
Sarah B. Crist, Travis Nemkov, Ruth F. Dumpit, Jinxiang Dai, Stephen J. Tapscott, Lawrence D. True, Alexander Swarbrick, Lucas B. Sullivan, Peter S. Nelson, Kirk C. Hansen, Cyrus M. Ghajar
Publikováno v:
Nature Cell Biology. 24:538-553
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e874c25a1dab0e446674ac55657765f
https://doi.org/10.1038/s41556-022-00881-4
https://doi.org/10.1038/s41556-022-00881-4
Autor:
Kate E Coleman, Miklós Békés, Jessica R Chapman, Sarah B Crist, Mathew JK Jones, Beatrix M Ueberheide, Tony T Huang
Publikováno v:
eLife, Vol 6 (2017)
NEDD8 is a ubiquitin-like modifier most well-studied for its role in activating the largest family of ubiquitin E3 ligases, the cullin-RING ligases (CRLs). While many non-cullin neddylation substrates have been proposed over the years, validation of
Externí odkaz:
https://doaj.org/article/ad1805509ac84579a8e2fb16bf8f7af8
Autor:
Sarah B Crist, Cyrus M. Ghajar
Publikováno v:
Annual Review of Pathology: Mechanisms of Disease. 16:409-432
Over the last four decades, the cancer biology field has concentrated on cellular and microenvironmental drivers of metastasis. Despite this focus, mortality rates upon diagnosis of metastatic disease remain essentially unchanged. Would a small chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190286548decf09bccb6874aba4bdf0c
https://doi.org/10.1146/annurev-pathmechdis-012419-032647
https://doi.org/10.1146/annurev-pathmechdis-012419-032647
Autor:
Miklós Békés, Keiji Okamoto, Sarah B. Crist, Mathew J. Jones, Jessica R. Chapman, Bradley B. Brasher, Francesco D. Melandri, Beatrix M. Ueberheide, Eros Lazzerini Denchi, Tony T. Huang
Publikováno v:
Cell Reports, Vol 5, Iss 3, Pp 826-838 (2013)
The ubiquitin-modification status of proteins in cells is highly dynamic and maintained by specific ligation machineries (E3 ligases) that tag proteins with ubiquitin or by deubiquitinating enzymes (DUBs) that remove the ubiquitin tag. The developmen
Externí odkaz:
https://doaj.org/article/4c428e4f12bb433a823c7305ee785255
Autor:
Sarah B, Crist, Travis, Nemkov, Ruth F, Dumpit, Jinxiang, Dai, Stephen J, Tapscott, Lawrence D, True, Alexander, Swarbrick, Lucas B, Sullivan, Peter S, Nelson, Kirk C, Hansen, Cyrus M, Ghajar
Publikováno v:
Nature cell biology. 24(4)
Skeletal muscle has long been recognized as an inhospitable site for disseminated tumour cells (DTCs). Yet its antimetastatic nature has eluded a thorough mechanistic examination. Here, we show that DTCs traffic to and persist within skeletal muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb4d4313fd88af4eab1087d21020139c
https://pubmed.ncbi.nlm.nih.gov/35610516
https://pubmed.ncbi.nlm.nih.gov/35610516
Autor:
Sarah B. Crist, Travis Nemkov, Ruth F. Dumpit, Jinxiang Dai, Stephen J. Tapscott, Lawrence D. True, Alexander Swarbrick, Lucas B. Sullivan, Peter S. Nelson, Kirk C. Hansen, Cyrus M. Ghajar
Publikováno v:
Nature Cell Biology. 24:1177-1177
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cbb9bfba821776410ea8c866f6dea7d
https://doi.org/10.1038/s41556-022-00945-5
https://doi.org/10.1038/s41556-022-00945-5
Autor:
Cyrus M. Ghajar, Sarah B Crist
Publikováno v:
Cell Systems. 6:268-270
Summary Watson et al. use microenvironment microarrays to assess how extrinsic signals within the tumor microenvironment influence HER2 ++ breast cancer resistance to the HER2-targeted tyrosine kinase inhibitor lapatinib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e70f62e2178af36de0d3a1e4dba1ef0
https://doi.org/10.1016/j.cels.2018.03.005
https://doi.org/10.1016/j.cels.2018.03.005