A guide to developing population files for physiologically‐based pharmacokinetic modeling in the Simcyp Simulator

Autor: Liam Curry, Sarah Alrubia, Frederic Y. Bois, Ruth Clayton, Eman El‐Khateeb, Trevor N. Johnson, Muhammad Faisal, Sibylle Neuhoff, Kris Wragg, Amin Rostami‐Hodjegan

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 9, Pp 1429-1447 (2024)

Abstract The Simcyp Simulator is a software platform widely used in the pharmaceutical industry to conduct stochastic physiologically‐based pharmacokinetic (PBPK) modeling. This approach has the advantage of combining routinely generated in vitro d

Externí odkaz: https://doaj.org/article/769597f4e2694f17b0ec0f0ede76ea59

A Simple Eco-Friendly HPLC-PDA Method for the Simultaneous Determination of Paclitaxel and Seliciclib in Plasma Samples for Assessing Their Pharmacodynamics and Pharmacokinetics in Combination Therapy for Uterine Sarcoma

Autor: Amsha S. Alsegiani, Sarah Alrubia, Ibrahim A. Darwish

Publikováno v: Medicina, Vol 60, Iss 10, p 1601 (2024)

Background/Objectives: Uterine sarcoma, a rare cancer originating in the smooth muscle of the uterus, exhibits high rates of recurrence and metastasis. It represents one of the most challenging types of cancer due to its chemorefractory nature, showi

Externí odkaz: https://doaj.org/article/a6eea9d90c4d48b2a2ba1c43b9a1392c

Physical and chemical screening of honey samples available in the Saudi market: An important aspect in the authentication process and quality assessment

Autor: Haya I. Aljohar, Hadir M. Maher, Jawza Albaqami, Maha Al-Mehaizie, Rawan Orfali, Razan Orfali, Sarah Alrubia

Publikováno v: Saudi Pharmaceutical Journal, Vol 26, Iss 7, Pp 932-942 (2018)

Honey is becoming accepted as a reputable and effective therapeutic agent by practitioners of conventional medicine and by the general public. It has many biological activities and has been effectively used in the treatment of many diseases, e.g. gas

Externí odkaz: https://doaj.org/article/82b677ae21ea4e0bb768e2c88ec9940c

Mass spectrometry‐based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin

Autor: Zubida M. Al-Majdoub, Noura Alohali, Sibylle Neuhoff, Amin Rostami-Hodjegan, Eman El-Khateeb, Areti-Maria Vasilogianni, Narciso Couto, Lutz Schmitt, Yasmine Elmorsi, Daniel Scotcher, Sarah Alrubia, Jill Barber, Martyn Howard, Brahim Achour

Publikováno v: Febs Letters
Al-Majdoub, Z, Achour, B, Couto, N, Howard, M, Elmorsi, Y, Scotcher, D, Alrubia, S, Elkhateeb, E, Vasilogianni, A M, Alohali, N, Neuhoff, S, Schmidt, L, Rostami-Hodjegan, A & Barber, J 2020, ' Mass Spectrometry-Based Abundance Atlas of ABC Transporters in Human Liver, Gut, Kidney, Brain, and Skin ', FEBS Letters . https://doi.org/10.1002/1873-3468.13982

ABC transporters (ATP-binding cassette transporter) traffic drugs and their metabolites across membranes, making ABC transporter expression levels a key factor regulating local drug concentrations in different tissues and individuals. Yet, quantifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66fe579975fefab2c8e18ad1517978ad
http://europepmc.org/articles/PMC7756589

Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters

Autor: Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan, Brahim Achour

Publikováno v: Drug metabolism and disposition
Barber, J, Al-Majdoub, Z M, Couto, N, Vasilogianni, A-M, Tillmann, A, Alrubia, S, Rostami-Hodjegan, A & Achour, B 2022, ' Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters ', Drug Metabolism and Disposition, vol. 50, no. 6, pp. 762-769 . https://doi.org/10.1124/dmd.121.000780

Building and refining pharmacology models require "system" data derived from tissues and in vitro systems analyzed by quantitative proteomics. Label-free global proteomics offers a wide scope of analysis, allowing simultaneous quantification of thous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0751521e4dbfdfe673b0a7ea487c7606
https://pubmed.ncbi.nlm.nih.gov/35307650