Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sarah Allman"'
Autor:
Sarah Allman, James P. Hall
Publikováno v:
Pharmacy Education. 20:365-374
Students studying Pharmacy often lack motivation to engage with chemical principles. In particular, they often find fundamental chemical concepts such as the visualization of three-dimensional structures challenging. This programme description report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::754dbc9076eae84dfbbb1f50a8a881db
https://doi.org/10.46542/pe.2020.201.365374
https://doi.org/10.46542/pe.2020.201.365374
Publikováno v:
bioRxiv
SummaryPan-caspase inhibitor Z-VAD-fmk acts as an inhibitor of peptide:N-glycanase (NGLY1); an endoglycosidase which cleavesN-linked glycans from glycoproteins exported from the endoplasmic reticulum during ER-associated degradation (ERAD). Pharmacol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ea8c2ea85c06e7d650b67e0ca8bf7c
https://doi.org/10.1101/2020.12.05.400481
https://doi.org/10.1101/2020.12.05.400481
Autor:
Julian Steinhoegl, Olga Eguaogie, Patrick F. Conlon, Christopher J. Law, Jamie S. T. Sweet, Sarah Allman, Jordan J. Wilson, Oliver G. A. Hancox, James H. R. Tucker, Klaudia Englert, Joseph S. Vyle, James P. Hall
Publikováno v:
Conlon, P, Eguaogie, O, Wilson, J, Sweet, J, Steinhoegl, J, Englert, K, Hancox, O, Law, C, Allman, S, Tucker, J H R, Hall, J & Vyle, J 2019, ' Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography ', Chemical Science, vol. 10, pp. 10948-10957 . https://doi.org/10.1039/C9SC04098F
Oligodeoxynucleotides incorporating internucleotide phosphoroselenolate linkages have been prepared under solid-phase synthesis conditions using dimer phosphoramidites. These dimers were constructed following the high yielding Michaelis-Arbuzov (M-A)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bf37a04d1a39a1ef5481f8b8c7ad79
https://centaur.reading.ac.uk/86671/9/c9sc04098f.pdf
https://centaur.reading.ac.uk/86671/9/c9sc04098f.pdf
The study of cellular Ca2+ signalling is indebted to Roger Tsien for the invention of fluorescent indicators that can be readily loaded into living cells and provide the means to measure cellular Ca2+ changes over long periods of time with sub-second
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9470dc0f4a1874fa7d01c01c5b120c9
https://lirias.kuleuven.be/handle/123456789/627706
https://lirias.kuleuven.be/handle/123456789/627706
Autor:
Camille Bonomelli, Sarah Allman, James H. Scrivens, David Harvey, Matthew Edgeworth, Benjamin A. Krishna, Max Crispin
Publikováno v:
Rapid Communications in Mass Spectrometry. 28:2008-2018
RATIONALE: Negative ion collision-induced dissociation (CID) spectra of N-glycans contain many diagnostic ions that provide more structural information than positive ion spectra. EndoH or endoS release of glycans from glycoproteins, as used by many i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57302e35b93427640fa6cdbc78837171
https://doi.org/10.1002/rcm.6980
https://doi.org/10.1002/rcm.6980
Autor:
Sarah Allman, Noor Haza Fazlin Hashim, Shazilah Kamaruddin, Nor Muhammad Mahadi, Abdul Munir Abd. Murad, Dharshini Elangovan, Muhammad Mukram Mohamed Mackeen, Farah Diba Abu Bakar
Publikováno v:
AIP Conference Proceedings.
The controlled synthesis of oligosaccharides is of growing interest due to the important roles of oligosaccharides in various biological processes. Enzymatic synthesis enables regio- and stereo-selective control during synthesis which still remains a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9271d4bacb403614ced21b263ae00022
https://doi.org/10.1063/1.4966749
https://doi.org/10.1063/1.4966749
Autor:
Jennifer Hellier, Neil G. Berry, Chandrakala Pidathala, Eleanor C. Row, Jean-Francois Rossignol, Raman Sharma, Mazhar Iqbal, Brent E. Korba, Andrew V. Stachulski, Alison Helm, Geoffrey Edwards, Sarah Allman, Joanne Bentley, J. Edward Semple
Publikováno v:
Journal of Medicinal Chemistry. 54:4119-4132
We report the activities of a number of thiazolides [2-hydroxyaroyl-N-(thiazol-2-yl)amides] against hepatitis C virus (HCV) genotypes IA and IB, using replicon assays. The structure–activity relationships (SARs) of thiazolides against HCV are less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a7d5ecb54aba7ce8deb33266efd1430
https://doi.org/10.1021/jm200153p
https://doi.org/10.1021/jm200153p
Autor:
Esther León, Benjamin G. Davis, Yan Liu, Stephen Curry, Stephen Matthews, Nikolas Friedrich, Sarah Allman, Dominique Soldati-Favre, Savvas Saouros, James A. Garnett, Ten Feizi
Publikováno v:
Protein Science. 18:1935-1947
The intracellular protozoan Toxoplasma gondii is among the most widespread parasites. The broad host cell range of the parasite can be explained by carbohydrate microarray screening analyses that have demonstrated the ability of the T. gondii adhesiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b0797d972284350e1c561ecf9242b74
https://doi.org/10.1002/pro.204
https://doi.org/10.1002/pro.204
Autor:
David Harvey, Laura K. Pritchard, James H. Scrivens, Kavitha Baruah, Charlotte A. Scarff, Sarah Allman, Christopher N. Scanlan, Matthew Edgeworth, Max Crispin, Frank Sobott
Publikováno v:
Electrophoresis
Travelling wave ion mobility was investigated for its ability to separate N-glycans from other compounds and for resolution of isomers. Charged glycans, exemplified by sialylated complex N-glycans released from bovine fetuin and ionised by electrospr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ee1d789c2cef8a32d9153d46281d8e
https://hdl.handle.net/10067/1113110151162165141
https://hdl.handle.net/10067/1113110151162165141
Publikováno v:
Rasmussen, T S, Jensen, H H, Allman, S, Twigg, G & Butters, T 2011, ' Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease ', Bioorganic & Medicinal Chemistry, vol. 21 .
The potent and selective inhibitor of β-glucosidases, noeurostegine, was evaluated as an inhibitor of glucocerebrosidase (GCase) to give an IC(50) value of 0.4 μM, being 250- and 150-fold better than N-butyl and N-nonyl noeurostegine, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ce8c5d2eade716ea485001c825ebe7
https://pure.au.dk/portal/da/publications/synthesis-of-nalkylated-noeurostegines-and-evaluation-of-their-potential-as-treatment-for-gauchers-disease(3aa122bd-5107-4af4-a05f-d46465740080).html
https://pure.au.dk/portal/da/publications/synthesis-of-nalkylated-noeurostegines-and-evaluation-of-their-potential-as-treatment-for-gauchers-disease(3aa122bd-5107-4af4-a05f-d46465740080).html