Characterizing microglial gene expression in a model of secondary progressive multiple sclerosis

Autor: Ilia D. Vainchtein, Astrid M. Alsema, Marissa L. Dubbelaar, Corien Grit, Jonathan Vinet, Hilmar R. J. van Weering, Sarah Al‐Izki, Giuseppe Biagini, Nieske Brouwer, Sandra Amor, David Baker, Bart J. L. Eggen, Erik W. G. M. Boddeke, Susanne M. Kooistra

Publikováno v: GLIA. John Wiley and Sons Inc.
Vainchtein, I D, Alsema, A M, Dubbelaar, M L, Grit, C, Vinet, J, van Weering, H R J, Al-Izki, S, Biagini, G, Brouwer, N, Amor, S, Baker, D, Eggen, B J L, Boddeke, E W G M & Kooistra, S M 2023, ' Characterizing microglial gene expression in a model of secondary progressive multiple sclerosis ', Glia, vol. 71, no. 3, pp. 588-601 . https://doi.org/10.1002/glia.24297
Vainchtein, I D, Alsema, A M, Dubbelaar, M L, Grit, C, Vinet, J, van Weering, H R J, Al-Izki, S, Biagini, G, Brouwer, N, Amor, S, Baker, D, Eggen, B J L, Boddeke, E W G M & Kooistra, S M 2022, ' Characterizing microglial gene expression in a model of secondary progressive multiple sclerosis ', GLIA . https://doi.org/10.1002/glia.24297
Glia, 71(03). Wiley

Multiple sclerosis (MS) is the most common inflammatory, demyelinating and neurodegenerative disease of the central nervous system in young adults. Chronic-relapsing experimental autoimmune encephalomyelitis (crEAE) in Biozzi ABH mice is an experimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a37dff039923b16ed6d6e4efd26f328
https://research.vumc.nl/en/publications/22e89f8d-6973-4442-b81d-9546de1dee9b

Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis

Autor: Samuel J. Jackson, David Baker, Sarah Al-Izki, Gavin Giovannoni, Gareth Pryce

Publikováno v: Multiple Sclerosis Journal. 17:939-948

Background: There has been poor translation for the use of immunosuppressive agents from experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), into the treatment of MS. This may be due to the fact that most EAE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524d2acf703527c037bfd48e1b0fa1ce
https://doi.org/10.1177/1352458511400476

Evaluating potential therapies for bladder dysfunction in a mouse model of multiple sclerosis with high-resolution ultrasonography

Autor: David Baker, Gavin Giovannoni, Sarah Al-Izki, Gareth Pryce

Publikováno v: Multiple Sclerosis Journal. 15:795-801

Background In multiple sclerosis (MS), demyelinating and neurodegenerative lesions develop throughout the central nervous system, which result in a loss of neurotransmission. As a result, people with MS exhibit a wide range of symptoms including dysf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c35c037a2dcd7597445df0143c5a6a0
https://doi.org/10.1177/1352458509104594

Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists

Autor: Lia E. De Faveri, Beat Lutz, Catherine Ledent, Sreeram V. Ramagopalan, Alan J. Thompson, Cristina Visintin, Sarah A. Thomas, Sarah Al-Izki, Helga E. de Vries, David Baker, Gareth Pryce, Charles A. Mein, Rosamond A. Nuamah, Gijs Kooij, Sandra Amor, Alison J. Hardcastle, Alexandre Montpetit, Giovanni Marsicano, David L. Selwood, Gavin Giovannoni

Publikováno v: Pryce, G, Visintin, C, Ramagopalan, S V, Al-Izki, S, De Faveri, L E, Nuamah, R A, Mein, C A, Montpetit, A, Hardcastle, A J, Kooij, G, de Vries, H E, Amor, S, Thomas, S A, Ledent, C, Marsicano, G, Lutz, B, Thompson, A J, Selwood, D L, Giovannoni, G & Baker, D 2014, ' Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists ', FASEB Journal, vol. 28, no. 1, pp. 117-130 . https://doi.org/10.1096/fj.13-239442
The FASEB Journal
FASEB Journal, 28(1), 117-130. FASEB

The purpose of this study was the generation of central nervous system (CNS)-excluded cannabinoid receptor agonists to test the hypothesis that inhibition of spasticity, due to CNS autoimmunity, could be controlled by affecting neurotransmission with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16377dc85c8f4eb50906601a471e9c6
https://research.vumc.nl/en/publications/2f9bfd85-4db5-4c1f-a430-f22c3a676700

Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis

Autor: Lorcan Browne, Gavin Giovannoni, David Baker, Katie Lidster, Alexander Montoya, Paul van der Valk, Simon P. Joel, David L. Selwood, A. W. Edith Chan, John Garthwaite, Wouter H. Gerritsen, Lisa Clutterbuck, Deborah J.R. Hankey, Kimberley Ummenthum, Regina Peferoen-Baert, Victoria Perkins, Sandra Amor, Cristina Garcia Posada, Stephanie von Kutzleben, Sarah Al-Izki, Gareth Pryce

Publikováno v: Al-Izki, S, Pryce, G, Hankey, D J R, Lidster, K, von Kutzleben, S M, Browne, L, Clutterbuck, L, Posada, C, Chan, A W E, Amor, S, Perkins, V, Gerritsen, W H, Ummenthum, K, Peferoen-Baert, R, van der Valk, P, Montoya, A, Joel, S P, Garthwaite, J, Giovannoni, G, Selwood, D L & Baker, D 2014, ' Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis ', Brain, vol. 137, pp. 92-108 . https://doi.org/10.1093/brain/awt324
Brain, 137, 92-108. Oxford University Press

Progressive multiple sclerosis is associated with metabolic failure of the axon and excitotoxicity that leads to chronic neurodegeneration. Global sodium-channel blockade causes side effects that can limit its use for neuroprotection in multiple scle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ddf03e4d72603e3e1e49355a7502915
https://pubmed.ncbi.nlm.nih.gov/24287115