Výsledky vyhledávání - "Sarah A. Wacker"

Self-regulation of exopolysaccharide production in Bacillus subtilis by a tyrosine kinase

Autor: Richard Losick, Alexander K. W. Elsholz, Sarah A. Wacker

Publikováno v: Genes & Development. 28:1710-1720

We report that the Bacillus subtilis exopolysaccharide (EPS) is a signaling molecule that controls its own production. EPS synthesis depends on a tyrosine kinase that consists of a membrane component (EpsA) and a kinase component (EpsB). EPS interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56926cb0c22778d811b1f55fb9a3657e
https://doi.org/10.1101/gad.246397.114

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Ligand-induced changes in the conformational stability and flexibility of glutamate dehydrogenase and their role in catalysis and regulation

Autor: Ellis Bell, Sarah A. Wacker, Michael J. Bradley, Jimmy Marion

Publikováno v: Protein Science. 19:1820-1829

Bovine glutamate dehydrogenase (GDH) is allosterically regulated and requires substrate-induced subunit interactions for maximum catalytic activity. Steady-state and presteady-state kinetics indicate that the rate-limiting step depends on the nature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cb8bfd1ec075a6e5eb27fc45ee9f269
https://doi.org/10.1002/pro.459

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Using transcriptome sequencing to identify mechanisms of drug action and resistance

Autor: Tarun M. Kapoor, Benjamin R. Houghtaling, Olivier Elemento, Sarah A. Wacker

Publikováno v: Nature chemical biology

Determining mechanisms of drug action in human cells remains a major challenge. Here we describe an approach in which multiple-drug-resistant clones are isolated and transcriptome sequencing is used to find mutations in each clone. Further analysis o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d676070933bf27f22830ac4649066dca
http://europepmc.org/articles/PMC3281560

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