Zobrazeno 1 - 10
of 554
pro vyhledávání: '"Sarah A. O'Brien"'
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mice with a mutation at the LAT-PLCγ1 binding site (Y136) have a defect in thymocyte development due to dampened TCR signaling. CD4+ T cells that do reach the periphery are hyper-activated and skewed to Th2. Over time, these mice develop an autoimmu
Externí odkaz:
https://doaj.org/article/e82c08c5dcbf49dca11d4b99865ad56e
Autor:
Caoimhe McKerr, Rachel M. Chalmers, Kristin Elwin, Heather Ayres, Roberto Vivancos, Sarah J. O’Brien, Robert M. Christley
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Infection with the Cryptosporidium parasite causes over 4000 cases of diagnosed illness (cryptosporidiosis) in England and Wales each year. The incidence of sporadic disease has not been sufficiently established, and how frequentl
Externí odkaz:
https://doaj.org/article/76a9bc172d284f3599e8de203a99d783
Autor:
Charis Stanek, Charleen I Theroux, Anna L Olsavsky, Kylie N Hill, Joseph R Rausch, Sarah H O'Brien, Gwendolyn P Quinn, Cynthia A Gerhardt, Leena Nahata
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0263886 (2022)
Many childhood cancer survivors desire biological children but are at risk for infertility after treatment. One option for mitigating risk is the use of fertility preservation prior to gonadotoxic therapy. Adolescents and emerging adults may rely on
Externí odkaz:
https://doaj.org/article/20f39d2fac5c410095d69b97b44492ae
Autor:
Sarah H. O’Brien
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 1, Pp 16-18 (2020)
Externí odkaz:
https://doaj.org/article/eff8072fb1154fcc8c4f70e4af13be62
Autor:
Stephen P. Rushton, Roy A. Sanderson, Peter J. Diggle, Mark D. F. Shirley, Alasdair P. Blain, Iain Lake, James A. Maas, William D. K. Reid, Jo Hardstaff, Nicola Williams, Natalia R. Jones, Daniel Rigby, Norval J. C. Strachan, Ken J. Forbes, Paul R. Hunter, Thomas J. Humphrey, Sarah J. O’Brien
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-13 (2019)
Abstract Background With over 800 million cases globally, campylobacteriosis is a major cause of food borne disease. In temperate climates incidence is highly seasonal but the underlying mechanisms are poorly understood, making human disease control
Externí odkaz:
https://doaj.org/article/9edca916eb104ab6a5194beff8d02a32
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background Norovirus is the commonest cause of infectious intestinal disease (IID) worldwide. In the UK community incidence of norovirus has been estimated at 59/1000 population, equating to four million cases a year. Whilst norovirus infect
Externí odkaz:
https://doaj.org/article/3f42af4b8350450bb8a2aecfedf779e0
Autor:
Thomas Inns, Helen E. Clough, John P. Harris, Roberto Vivancos, Natalie Adams, Sarah J. O’Brien
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background Outbreaks of infectious gastroenteritis in care homes are common, with norovirus a frequent cause. In England there is no co-ordinated national surveillance system. We aimed to estimate the burden of these outbreaks. Methods Using
Externí odkaz:
https://doaj.org/article/34372839e1cf4c9393c67bbd6c6dddd4
Autor:
Jennie C. Kim, Xian Liu, Karen Fitzgerald, Jason S. Eng, Jessica Orf, Sarah A. O’Brien, Brian Belmontes, Amy-Jo Casbon, Sergey V. Novitskiy, Kristin V. Tarbell, Jason DeVoss, Jackson G. Egen
Publikováno v:
Cancer Immunology, Immunotherapy. 72:1327-1335
Type I interferon-mediated activation of immune cells can facilitate the generation of productive tumor antigen-specific T cell responses in solid tumors. The cGAS/STING DNA sensing pathway is a critical upstream mediator of type I interferon product
Autor:
Sarah Joanne O'Brien
Publikováno v:
Body, Space & Technology Journal, Vol 19, Iss 1 (2020)
Marina Warner states that the concept of the zombie ‘embodies the condition of our time’ as it represents contemporary experiences of selfhood shaped by new technologies (2006: 357–8). In this paper I argue that, due to the interactive and imme
Externí odkaz:
https://doaj.org/article/47cdf976de7c472485aae81342aa40a6
Autor:
Sam Haldenby, Christina Bronowski, Charlotte Nelson, John Kenny, Carmen Martinez-Rodriguez, Roy Chaudhuri, Nicola J Williams, Ken Forbes, Norval J Strachan, Jane Pulman, Ian N Winstanley, Caroline E Corless, Tom J Humphrey, Frederick J Bolton, Sarah J O'Brien, Neil Hall, Christiane Hertz-Fowler, Craig Winstanley
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227535 (2020)
BackgroundCampylobacter jejuni is the most common bacterial cause of human infectious intestinal disease.MethodsWe genome sequenced 601 human C. jejuni isolates, obtained from two large prospective studies of infectious intestinal disease (IID1 [isol
Externí odkaz:
https://doaj.org/article/72fd2b751da34c56b4103af86ab2d938