Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sarah A. McMurtry"'
Autor:
James F. Colbert, Joshua M. Kirsch, Christopher L. Erzen, Christophe J. Langouët-Astrié, Grace E. Thompson, Sarah A. McMurtry, Jennifer M. Kofonow, Charles E. Robertson, Elizabeth J. Kovacs, Ryan C. Sullivan, Joseph A. Hippensteel, Namrata V. Sawant, Nicole J. De Nisco, Bruce D. McCollister, Robert S. Schwartz, Alexander R. Horswill, Daniel N. Frank, Breck A. Duerkop, Eric P. Schmidt
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Prior research has focused on host factors as mediators of exaggerated sepsis-associated morbidity and mortality in older adults. This focus on the host, however, has failed to identify therapies that improve sepsis outcomes in the elderly.
Externí odkaz:
https://doaj.org/article/3534f0ab7eb1418a8befb8cb4e008912
Autor:
Alicia N. Rizzo, Sarah M. Haeger, Kaori Oshima, Yimu Yang, Alison M. Wallbank, Ying Jin, Marie Lettau, Lynda A. McCaig, Nancy E. Wickersham, J. Brennan McNeil, Igor Zakharevich, Sarah A. McMurtry, Christophe J. Langouët-Astrié, Katrina W. Kopf, Dennis R. Voelker, Kirk C. Hansen, Ciara M. Shaver, V. Eric Kerchberger, Ryan A. Peterson, Wolfgang M. Kuebler, Matthias Ochs, Ruud A.W. Veldhuizen, Bradford J. Smith, Lorraine B. Ware, Julie A. Bastarache, Eric P. Schmidt
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure yet has few pharmacologic therapies, reflecting the mechanistic heterogeneity of lung injury. We hypothesized that damage to the alveolar epithelial glycocalyx, a lay
Externí odkaz:
https://doaj.org/article/31aa2a1550884c5a8f8b113a7914671a
Autor:
Joseph A. Hippensteel, Ryo Uchimido, Patrick D. Tyler, Ryan C. Burke, Xiaorui Han, Fuming Zhang, Sarah A. McMurtry, James F. Colbert, Christopher J. Lindsell, Derek C. Angus, John A. Kellum, Donald M. Yealy, Robert J. Linhardt, Nathan I. Shapiro, Eric P. Schmidt
Publikováno v:
Critical Care, Vol 23, Iss 1, Pp 1-10 (2019)
Abstract Background Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models suggest that fluid resuscitation degrades the endothelial glycocalyx, a h
Externí odkaz:
https://doaj.org/article/ae7b20a88cc94d08add62de6c3bc9b4b
Publikováno v:
Pulmonary Circulation, Vol 7 (2017)
Pulmonary artery, capillary, and vein endothelial cells possess distinctive structures and functions, which represent a form of vascular segment specific macroheterogeneity. However, within each of these segmental populations, individual cell functio
Externí odkaz:
https://doaj.org/article/6aff7176344a444ab2ccab26fcdb19d1
Publikováno v:
Seminars in Thrombosis and Hemostasis. 47:274-282
There is increasing recognition of the importance of the endothelial glycocalyx and its in vivo manifestation, the endothelial surface layer, in vascular homeostasis. Heparan sulfate proteoglycans (HSPGs) are a major structural constituent of the end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d15a9de56fee78a9bc68f5892113ff
https://doi.org/10.1055/s-0041-1725064
https://doi.org/10.1055/s-0041-1725064
Autor:
Sarah M. Haeger, Yimu Yang, Kaori Oshima, Xiaorui Han, S. Liao, S Yan, Robert J. Linhardt, M Ransom, Fuming Zhang, Wells B. LaRivière, Eric P. Schmidt, Julie A. Bastarache, Sarah A. McMurtry
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
The pulmonary epithelial glycocalyx, an anionic cell surface layer enriched in glycosaminoglycans such as heparan sulfate and chondroitin sulfate, contributes to the alveolar barrier. Direct injury to the pulmonary epithelium induces shedding of hepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8f0f9d9d3ddda48a93af92d6505fd2
https://doi.org/10.1152/ajplung.00063.2020
https://doi.org/10.1152/ajplung.00063.2020
Autor:
Fuming Zhang, Yimu Yang, Sarah A. McMurtry, Xinping Yue, Sarah M. Haeger, Yilan Ouyang, Eric P. Schmidt, Xiaorui Han, Trevor Lane, Pavel Davizon-Castillo, Robert J. Linhardt, Kaori Oshima, Rana El Masri, Romain R. Vivès
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2019, ⟨10.1152/ajplung.00175.2019⟩
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2019, ⟨10.1152/ajplung.00175.2019⟩
American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2019, ⟨10.1152/ajplung.00175.2019⟩
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2019, ⟨10.1152/ajplung.00175.2019⟩
International audience; 2019.-Sepsis patients are at increased risk for hospital-acquired pulmonary infections, potentially due to postseptic immunosuppression known as the compensatory anti-inflammatory response syndrome (CARS). CARS has been attrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa8a2c6e6090add0aa167a9763200ae
https://doi.org/10.1152/ajplung.00175.2019
https://doi.org/10.1152/ajplung.00175.2019
Autor:
Joshay A. Ford, Yimu Yang, Eric P. Schmidt, Sarah A. McMurtry, Kaori Oshima, Xing Zhang, Jian Liu, Ke Xia, Paco S. Herson, Xiaorui Han, Sarah M. Haeger, Yongmei Xu, Joseph A. Hippensteel, Mario J. Perez, Robert J. Linhardt
Publikováno v:
Proceedings of the National Academy of Sciences. 116:9208-9213
Sepsis induces heparanase-mediated degradation of the endothelial glycocalyx, a heparan sulfate-enriched endovascular layer critical to vascular homeostasis, releasing highly sulfated domains of heparan sulfate into the circulation. These domains are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f250371dba28127ec8e6bd2ee818c3bf
https://doi.org/10.1073/pnas.1902227116
https://doi.org/10.1073/pnas.1902227116
Autor:
S. Yan, S. Liao, Fuming Zhang, Kaori Oshima, Robert J. Linhardt, Sarah A. McMurtry, Wells B. LaRivière, Eric P. Schmidt, Yimu Yang, Sarah M. Haeger
Publikováno v:
B67. UNDERSTANDING LUNG INJURY: FROM GENE TO DYSFUNCTION.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030803cce6e30545e574f8215dfdfba0
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4112
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4112
Autor:
Eric P. Schmidt, Rubin M. Tuder, Kaori Oshima, Julie A. Bastarache, J. Brennan McNeil, Eva Nozik-Grayck, Xinyue Liu, Fuming Zhang, Yimu Yang, Yilan Ouyang, Xiaorui Han, Robert J. Linhardt, Sarah A. McMurtry, Sarah M. Haeger, Rachel L. Zemans
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 59:363-374
The lung epithelial glycocalyx is a carbohydrate-enriched layer lining the pulmonary epithelial surface. Although epithelial glycocalyx visualization has been reported, its composition and function remain unknown. Using immunofluorescence and mass sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e1c5105d290055b3089194011e87ee
https://doi.org/10.1165/rcmb.2017-0428oc
https://doi.org/10.1165/rcmb.2017-0428oc