Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sarah A. McClymont"'
Autor:
Rachel J. Boyd, Sarah A. McClymont, Nelson B. Barrientos, Paul W. Hook, William D. Law, Rebecca J. Rose, Eric L. Waite, Jay Rathinavelu, Dimitrios Avramopoulos, Andrew S. McCallion
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract To overcome the ethical and technical limitations of in vivo human disease models, the broader scientific community frequently employs model organism-derived cell lines to investigate disease mechanisms, pathways, and therapeutic strategies.
Externí odkaz:
https://doaj.org/article/026f85d2ff5a46fca1232db9779e406c
Autor:
Hannah E. Edelman, Tori Tucker, Santiago Pineda, Andrew S. McCallion, Michael J. Parsons, Sarah A. McClymont, Rebecca L. Beer
Publikováno v:
Hum Mol Genet
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive form of cancer with high mortality. The cellular origins of PDAC are largely unknown; however, ductal cells, especially centroacinar cells (CACs), have several characteristics in common with PD
Autor:
Marja W. Wessels, Cassandra R. Moats, Hanna Björk, Christian L. Lino Cardenas, Per Eriksson, Andrew S. McCallion, Honghuang Lin, Vinod Jaskula-Ranga, Ann-Cathrin Lehsau, Gregor Andelfinger, Lut Van Laer, Patrick T. Ellinor, Salah A. Mohamed, Ajay Anand Kumar, Asad A. Shah, Nara Sobreira, Eric M. Isselbacher, Djahida Bedja, Harry C. Dietz, Rebecca Rose, Anders Franco-Cereceda, Elyssa Cannaerts, Aline Verstraeten, Hamza Aziz, Luc Mertens, Gretchen MacCarrick, Seema Mital, Russell A. Gould, Ilse Luyckx, Judith M.A. Verhagen, Henrik Hein Lauridsen, G. Chad Hughes, Mark E. Lindsay, Elizabeth Sparks, Florian Wünnemann, Christoph Preuss, Manuel Alejandro Seman-Senderos, Courtney E. Woods, Christopher L. Bennett, Bart Loeys, Jonathan T. Butcher, Hua Ling, Sarah A. McClymont
Publikováno v:
Nature Genetics, 51, 42
Nature Genetics, 51(1), 42-+. Nature Publishing Group
Nature Genetics, 51, 1, pp. 42
Gould, R A, Aziz, H, Woods, C E, Seman-Senderos, M A, Sparks, E, Preuss, C, Wünnemann, F, Bedja, D, Moats, C R, McClymont, S A, Rose, R, Sobreira, N, Ling, H, MacCarrick, G, Kumar, A A, Luyckx, I, Cannaerts, E, Verstraeten, A, Björk, H M, Lehsau, A-C, Jaskula-Ranga, V, Lauridsen, H, Shah, A A, Bennett, C L, Ellinor, P T, Lin, H, Isselbacher, E M, Cardenas, C L L, Butcher, J T, Hughes, G C, Lindsay, M E, Baylor-Hopkins Center for Mendelian Genomics, MIBAVA Leducq Consortium, Mertens, L, Franco-Cereceda, A, Verhagen, J M A, Wessels, M, Mohamed, S A, Eriksson, P, Mital, S, Van Laer, L, Loeys, B L, Andelfinger, G, McCallion, A S & Dietz, H C 2018, ' ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm ', Nature Genetics . https://doi.org/10.1038/s41588-018-0265-y
Nature genetics
Nature Genetics, 51(1), 42-+. Nature Publishing Group
Nature Genetics, 51, 1, pp. 42
Gould, R A, Aziz, H, Woods, C E, Seman-Senderos, M A, Sparks, E, Preuss, C, Wünnemann, F, Bedja, D, Moats, C R, McClymont, S A, Rose, R, Sobreira, N, Ling, H, MacCarrick, G, Kumar, A A, Luyckx, I, Cannaerts, E, Verstraeten, A, Björk, H M, Lehsau, A-C, Jaskula-Ranga, V, Lauridsen, H, Shah, A A, Bennett, C L, Ellinor, P T, Lin, H, Isselbacher, E M, Cardenas, C L L, Butcher, J T, Hughes, G C, Lindsay, M E, Baylor-Hopkins Center for Mendelian Genomics, MIBAVA Leducq Consortium, Mertens, L, Franco-Cereceda, A, Verhagen, J M A, Wessels, M, Mohamed, S A, Eriksson, P, Mital, S, Van Laer, L, Loeys, B L, Andelfinger, G, McCallion, A S & Dietz, H C 2018, ' ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm ', Nature Genetics . https://doi.org/10.1038/s41588-018-0265-y
Nature genetics
Bicuspid aortic valve (BAV) is a common congenital heart defect (population incidence, 1-2%) that frequently presents with ascending aortic aneurysm (AscAA)4. BAV/AscAA shows autosomal dominant inheritance with incomplete penetrance and male predomin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac737188dcd98e5b52030d1a762f253
http://hdl.handle.net/2066/201286
http://hdl.handle.net/2066/201286
Autor:
Cedric Moore, Michael G. Heckman, Nancy N. Diehl, Zbigniew K. Wszolek, Samuel J. Kerans, Heng Zhu, Len A. Pennacchio, Owen A. Ross, Paul W. Hook, Andrew S. McCallion, Xylena Reed, Alexandra I. Soto, Sarah A. McClymont, Axel Visel, Eric L. Waite, William D. Law, Diane E. Dickel, Michael A. Beer, Joey F. Thole, Nicole J. Briceno, Jennifer A. Akiyama
Publikováno v:
American journal of human genetics, vol 103, iss 6
The progressive loss of midbrain (MB) dopaminergic (DA) neurons defines the motor features of Parkinson disease (PD) and modulation of risk by common variation in PD has been well established through GWAS. Anticipating that a fraction of PD-associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9105231d01ba5c93de7fee4bf0de38f6
https://escholarship.org/uc/item/96k576w4
https://escholarship.org/uc/item/96k576w4
Autor:
A. Jennifer Morton, Sarah A. McClymont, William D. Law, Andrew S. McCallion, Loyal A. Goff, Paul W. Hook, Gabrielle H. Cannon
Parkinson's Disease (PD) causes collapse of substantia nigra (SN) dopaminergic (DA) neurons of the midbrain (MB), while other DA populations are relatively spared. Here, we used single-cell RNA-seq (scRNA-seq) to characterize DA neuron populations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4663873450cbbceb861a91173638a4bc
Autor:
Russell A, Gould, Hamza, Aziz, Courtney E, Woods, Manuel Alejandro, Seman-Senderos, Elizabeth, Sparks, Christoph, Preuss, Florian, Wünnemann, Djahida, Bedja, Cassandra R, Moats, Sarah A, McClymont, Rebecca, Rose, Nara, Sobreira, Hua, Ling, Gretchen, MacCarrick, Ajay Anand, Kumar, Ilse, Luyckx, Elyssa, Cannaerts, Aline, Verstraeten, Hanna M, Björk, Ann-Cathrin, Lehsau, Vinod, Jaskula-Ranga, Henrik, Lauridsen, Asad A, Shah, Christopher L, Bennett, Patrick T, Ellinor, Honghuang, Lin, Eric M, Isselbacher, Christian Lacks, Lino Cardenas, Jonathan T, Butcher, G Chad, Hughes, Mark E, Lindsay, Luc, Mertens, Anders, Franco-Cereceda, Judith M A, Verhagen, Marja, Wessels, Salah A, Mohamed, Per, Eriksson, Seema, Mital, Lut, Van Laer, Bart L, Loeys, Gregor, Andelfinger, Andrew S, McCallion
Publikováno v:
Nature genetics. 51(1)
Bicuspid aortic valve (BAV) is a common congenital heart defect (population incidence, 1-2%)
Autor:
Kangfu Yu, Kirstin E. Bett, K. Peter Pauls, Robert Stonehouse, Alireza Navabi, Raja Khanal, Sarah A. McClymont, Weilong Xie
Publikováno v:
Molecular Breeding. 37
Common bacterial blight (CBB) is a major disease of common bean (Phaseolus vulgaris L.) worldwide. Genetic resistance is the most effective and environmentally safe approach for controlling CBB, and identification of resistance quantitative trait loc
Autor:
J. N. Berchie, G. Amelie, J. Sarkodie-Addo, Sarah A. McClymont, H. Adu-Dapaah, Manish N. Raizada
Publikováno v:
Journal of Agronomy. 12:20-28
The aim of this study was to identify bambara groundnut landraces which are less sensitive to photoperiod response. Variation in yields of bambara groundnut have been attributed among others to variation in photoperiod at different sowing dates. Thir
Publikováno v:
Crop Science. 51:2780-2795
Examination of wild ancestors can identify which traits have been altered by selection as possible targets for genetic improvement. We investigated the whole plant response to low nitrogen (LN), especially below ground, by the wild ancestor of modern
Publikováno v:
Plant, Cell & Environment. 34:2122-2137
There is interest in discovering root traits associated with acclimation to nutrient stress. Large root systems, such as in adult maize, have proven difficult to be phenotyped comprehensively and over time, causing target traits to be missed. These c