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pro vyhledávání: '"Sarah A. Mahn"'
Autor:
Kyler S. Crawford, Anthony E. Getschman, Sarah A. Mahn, John D. McCorvy, Adriano Marchese, Brian F. Volkman, Francis C. Peterson, Michael J. Wedemeyer
Publikováno v:
J Biol Chem
The human chemokine family consists of 46 protein ligands that induce chemotactic cell migration by activating a family of 23 G protein–coupled receptors. The two major chemokine subfamilies, CC and CXC, bind distinct receptor subsets. A sequence m
Publikováno v:
J Biol Chem
G protein–coupled receptor (GPCR) signaling is regulated by members of the protein kinase C (PKC) and GPCR kinase (GRK) families, although the relative contribution of each to GPCR function varies among specific GPCRs. The CXC motif receptor 4 (CXC
Publikováno v:
Journal of Biological Chemistry. 293:11470-11480
Signaling activated by binding of the CXC motif chemokine ligand 12 (CXCL12) to its cognate G protein–coupled receptor (GPCR), chemokine CXC motif receptor 4 (CXCR4), is linked to metastatic disease. However, the mechanisms governing CXCR4 signalin