Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sarah A. Lewin"'
Autor:
Paramita Ray, Sarah A. Lewin, Laura Anne Mihalko, Bradley T. Schmidt, Kathryn E. Luker, Gary D. Luker
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 12, Pp 1152-1161 (2011)
Patients with metastatic ovarian cancer continue to have a dismal prognosis, emphasizing the need for new strategies to identify and develop new molecular targets for therapy. Chemokine CXCL12 and its receptor CXCR4 are upregulated in metastatic ovar
Externí odkaz:
https://doaj.org/article/cc21fbe84bce45eb8d66f70132440c2c
We demonstrate that a poly(lactide-co-glycolide) (PLG) cancer vaccine can be used in combination with immune checkpoint antibodies, anti–CTLA-4 or anti–PD-1, to enhance cytotoxic T-cell (CTL) activity and induce the regression of solid B16 tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4675cee2980728b896b7c408859a8e9f
https://doi.org/10.1158/2326-6066.c.6548689.v1
https://doi.org/10.1158/2326-6066.c.6548689.v1
Figure S1 - Treatment of tumor bearing mice with anti-CTLA-4 and Anti-PD1 antibodies. Figure S2 - The effects of stopping antibody treatment after PLG vaccination on tumor growth. Figure S3 - The ratio of CD3(+)CD8(+) T cells to CD3(+)FoxP3(+) T regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7ff26b130dbde3c224a8f55736733a
https://doi.org/10.1158/2326-6066.22538149
https://doi.org/10.1158/2326-6066.22538149
Autor:
David J. Mooney, Glenn Dranoff, Edward Doherty, Des White, Sarah A. Lewin, R. Warren Sands, Chris Johnson, Catia Verbeke, Omar A. Ali
PDF file - 129KB, Activated dendritic cell numbers at the vaccine implant site (S1); The kinetics of activated dendritic cell generation at vaccine site (S2); IFN-a production at vaccine sites (S3); TNF-a production at vaccine sites (S4); Prophylacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab44d605463474e33593f63b71f694f
https://doi.org/10.1158/0008-5472.22400741.v1
https://doi.org/10.1158/0008-5472.22400741.v1
Autor:
David J. Mooney, Glenn Dranoff, Edward Doherty, Des White, Sarah A. Lewin, R. Warren Sands, Chris Johnson, Catia Verbeke, Omar A. Ali
PDF file - 237KB, Vaccine induction of inflammatory cytokine production at the vaccine site (S1); The correlation between local cytokine concentration and survival outcome in vaccinated mice (S2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c6abce299acfba132f1467548fee26
https://doi.org/10.1158/0008-5472.22400738
https://doi.org/10.1158/0008-5472.22400738
Autor:
David J. Mooney, Glenn Dranoff, Edward Doherty, Des White, Sarah A. Lewin, R. Warren Sands, Chris Johnson, Catia Verbeke, Omar A. Ali
The innate cellular and molecular components required to mediate effective vaccination against weak tumor-associated antigens remain unclear. In this study, we used polymeric cancer vaccines incorporating different classes of adjuvants to induce tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2597ca6a6548b83d219841f247ffba5f
https://doi.org/10.1158/0008-5472.c.6505655
https://doi.org/10.1158/0008-5472.c.6505655
Publikováno v:
Cancer Immunology Research. 4:95-100
We demonstrate that a poly(lactide-co-glycolide) (PLG) cancer vaccine can be used in combination with immune checkpoint antibodies, anti–CTLA-4 or anti–PD-1, to enhance cytotoxic T-cell (CTL) activity and induce the regression of solid B16 tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a231d17967276d7e2dbeceb570f848a0
https://doi.org/10.1158/2326-6066.cir-14-0126
https://doi.org/10.1158/2326-6066.cir-14-0126
Autor:
Brian J. Kwee, Theresa M. Raimondo, David J. Mooney, Manav Mehta, Sarah A. Lewin, Erin M. Anderson
Publikováno v:
Tissue Engineering Part A. 21:1217-1227
Biomaterials may improve outcomes of endothelial progenitor-based therapies for the treatment of ischemic cardiovascular disease, due to their ability to direct cell behavior. We hypothesized that local, sustained delivery of exogenous vascular endot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2985149c0e03d90cbba9204847c44e8c
https://doi.org/10.1089/ten.tea.2014.0508
https://doi.org/10.1089/ten.tea.2014.0508
Autor:
Young Jin Choi, David J. Mooney, Sarah A. Lewin, Catia S. Verbeke, Glenn Dranoff, Jaeyun Kim, Weiwei Aileen Li
Publikováno v:
Nature biotechnology
Implanting materials in the body to program host immune cells is a promising alternative to transplantation of cells manipulated ex vivo to direct an immune response, but doing so requires a surgical procedure. Here we demonstrate that high-aspect-ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412c8fbb6c9e1c45fa83879646483e83
https://doi.org/10.1038/nbt.3071
https://doi.org/10.1038/nbt.3071
Publikováno v:
Biomaterials. 35:2477-2487
The performance of biomaterials-based therapies can be hindered by complications associated with surgical implant, motivating the development of materials systems that allow minimally invasive introduction into the host. In this study, we created cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0737e89238c3b13ae579d8137bb0f11e
https://doi.org/10.1016/j.biomaterials.2013.11.044
https://doi.org/10.1016/j.biomaterials.2013.11.044