Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Sarah A. Hewitt"'
Autor:
Simon C.C. Lucas, J. Henry Blackwell, Sarah H. Hewitt, Hannah Semple, Benjamin C. Whitehurst, Hua Xu
Publikováno v:
SLAS Discovery, Vol 29, Iss 3, Pp 100142- (2024)
Covalent hits for drug discovery campaigns are neither fantastic beasts nor mythical creatures, they can be routinely identified through electrophile-first screening campaigns using a suite of different techniques. These include biophysical and bioch
Externí odkaz:
https://doaj.org/article/27d924496e8440509ecb62d8a6268f4d
Autor:
Ali Farzam, Karan Chohan, Miroslava Strmiskova, Sarah J. Hewitt, David S. Park, John P. Pezacki, Dennis Özcelik
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Recent findings suggest that dopamine oxidation contributes to the development of Parkinson's disease (PD); however, the mechanistic details remain elusive. Here, we compare 6-hydroxydopamine (6-OHDA), a product of dopamine oxidation that commonly in
Externí odkaz:
https://doaj.org/article/0e4706f190bd42b99b46ee2d838cf375
Autor:
Simon Wheeler, Colum Breen, Yong Li, Sarah H. Hewitt, Erin Robertson, Edwin A. Yates, Igor L. Barsukov, David G. Fernig, Stephen J. Butler
Publikováno v:
Organic & Biomolecular Chemistry. 20:596-605
Sulfotransferases constitute a ubiquitous class of enzymes which are poorly understood due to the lack of a convenient tool for screening their activity. These enzymes use the anion PAPS (adenosine-3'-phosphate-5'-phosphosulfate) as a donor for a bro
Autor:
Lucrezia Zuccarelli, Letizia Rasica, Trevor A. Day, Francesco Luciano, Isaac J. Wedig, Rafael Alves de Aguiar, Michael J. Asmussen, Jørgen Arendt Jensen, João Antônio Gesser Raimundo, Morten Hostrup, Luca Ruggiero, Sarah A. Hewitt, Gopika SenthilKumar, Steven J. Elmer, Jared R. Fletcher, Nicholas D. J. Strzalkowski, Gaspare Pavei
Publikováno v:
Journal of Applied Physiology. 131:1516-1519
Autor:
Sarah K. Hewitt, Kobchai Duangrattanalert, Tim Burgis, Leo A.H. Zeef, Samina Naseeb, Daniela Delneri
Publikováno v:
Microorganisms, Vol 8, Iss 4, p 494 (2020)
Mitochondrial DNA (mtDNA) in yeast is biparentally inherited, but colonies rapidly lose one type of parental mtDNA, thus becoming homoplasmic. Therefore, hybrids between the yeast species possess two homologous nuclear genomes, but only one type of m
Externí odkaz:
https://doaj.org/article/aa3b5d0b117b4482bd57a2d338c69d06
Autor:
Sarah E. Hewitt, Erik P. Southard
Publikováno v:
Journal of Patient Safety and Risk Management. :251604352311780
Background Exposure to bloodborne pathogens poses a serious risk to healthcare workers. As more primary care providers are being asked to perform occupational health services, the evaluation and treatment of bloodborne pathogen (BBP) exposures can be
Autor:
Gottfried Otting, Thomas R. Berki, Iresha D. Herath, Sarah H. Hewitt, Charlotte A. Dodson, Colum Breen, Nicholas Cox, Shereen Jabar, Stephen J. Butler, Martyna Judd, Ahmad F. Kassir
Publikováno v:
Herath, I D, Breen, C, Hewitt, S H, Berki, T R, Kassir, A F, Dodson, C, Judd, M, Jabar, S, Cox, N, Otting, G & Butler, S J 2021, ' A chiral lanthanide tag for stable and rigid attachment to single cysteine residues in proteins for NMR, EPR and time-resolved luminescence studies ', Chemistry-A European Journal . https://doi.org/10.1002/chem.202101143
Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry (Weinheim an Der Bergstrasse, Germany)
A lanthanide‐binding tag site‐specifically attached to a protein presents a tool to probe the protein by multiple spectroscopic techniques, including nuclear magnetic resonance, electron paramagnetic resonance and time‐resolved luminescence spe
Autor:
Sarah H. Hewitt, Fernanda Duarte, Mark R. J. Elsegood, Alan M. Kenwright, Romain Mailhot, Stephen J. Butler, Georgina Macey
Publikováno v:
Chemical Science
Chemical science, 2020, Vol.11(14), pp.3619-3628 [Peer Reviewed Journal]
Chemical science, 2020, Vol.11(14), pp.3619-3628 [Peer Reviewed Journal]
The development of synthetic receptors for the selective binding and discrimination of anions in water requires an understanding of how anions interact with these synthetic receptors. Molecules designed to differentiate nucleoside phosphate anions (e
Autor:
David G. Fernig, Colum Breen, Sarah H. Hewitt, Yong Li, Erin Robertson, Stephen J. Butler, Simon Wheeler
Sulfotransferases constitute a ubiquitous class of enzyme which are poorly understood due to the lack of a convenient tool for screening their activity. These enzymes use the anion PAPS (adenosine-3’-phosphate-5’-phosphosulfate) as a donor for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6c7545a4ba16d1f61626816a6e3c02
https://doi.org/10.33774/chemrxiv-2021-4ftrg
https://doi.org/10.33774/chemrxiv-2021-4ftrg
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92203 (2014)
Gross chromosomal rearrangements have the potential to be evolutionarily advantageous to an adapting organism. The generation of a hybrid species increases opportunity for recombination by bringing together two homologous genomes. We sought to define
Externí odkaz:
https://doaj.org/article/097d6bfa6fca41b99c027ce3588d017b