Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Sarah A. Head"'
Autor:
Miquel Anglada-Girotto, Ludovica Ciampi, Sophie Bonnal, Sarah A. Head, Samuel Miravet-Verde, Luis Serrano
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Alternative splicing is crucial for cancer progression and can be targeted pharmacologically, yet identifying driver exons genome-wide remains challenging. We propose identifying such exons by associating statistically gene-level cancer depe
Externí odkaz:
https://doaj.org/article/47cd56bdd35f4ce69a02ba166469da0f
Autor:
Sarah A. Head, Carter Johnson, Saheli Sarkar, Andrew Matteson, Diana H. Marcantonio, Fei Hua, John M. Burke, Joshua F. Apgar, David Flowers
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 6, Pp 919-925 (2024)
Abstract Immune checkpoint inhibitors block the interaction between a receptor on one cell and its ligand on another cell, thus preventing the transduction of an immunosuppressive signal. While inhibition of the receptor–ligand interaction is key t
Externí odkaz:
https://doaj.org/article/c1102aa2ecc540dd91df07ff2a7b6864
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background Independent Component Analysis (ICA) allows the dissection of omic datasets into modules that help to interpret global molecular signatures. The inherent randomness of this algorithm can be overcome by clustering many iterations o
Externí odkaz:
https://doaj.org/article/84befb490a774110805f0c0b715aabc2
Autor:
Jeroen R.P.M. Strating, Lonneke van der Linden, Lucian Albulescu, Joëlle Bigay, Minetaro Arita, Leen Delang, Pieter Leyssen, Hilde M. van der Schaar, Kjerstin H.W. Lanke, Hendrik Jan Thibaut, Rachel Ulferts, Guillaume Drin, Nina Schlinck, Richard W. Wubbolts, Navdar Sever, Sarah A. Head, Jun O. Liu, Philip A. Beachy, Maria A. De Matteis, Matthew D. Shair, Vesa M. Olkkonen, Johan Neyts, Frank J.M. van Kuppeveld
Publikováno v:
Cell Reports, Vol 10, Iss 4, Pp 600-615 (2015)
Itraconazole (ITZ) is a well-known antifungal agent that also has anticancer activity. In this study, we identify ITZ as a broad-spectrum inhibitor of enteroviruses (e.g., poliovirus, coxsackievirus, enterovirus-71, rhinovirus). We demonstrate that I
Externí odkaz:
https://doaj.org/article/bf5c36a32e6b4b4f8255f844489c246c
Autor:
Liu, Phillip R. Sanchez, Sarah A. Head, Shan Qian, Haibo Qiu, Avishek Roy, Zhendong Jin, Wei Zheng, Jun O.
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9575
Marine natural products represent a unique source for clinically relevant drugs due to their vast molecular and mechanistic diversity. ZJ-101 is a structurally simplified analog of the marine natural product superstolide A, isolated from the New Cale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::5186347b53638b1a1f5edc06bafb8a8a
Autor:
Jun O. Liu, Wei Shi, Junfang Lv, Eun Ju Yang, Kalyan Kumar Pasunooti, Sarah A. Head, Namandje N. Bumpus, Ruo-Jing Li, Joong Sup Shim
Purpose: Itraconazole is a triazole antifungal drug that has recently been found to inhibit angiogenesis. Itraconazole is a relatively well-tolerated drug but shows hepatotoxicity in a small subset of patients. Itraconazole contains three chiral cent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22bd1aee39e7b926a7f49f9bb428bdb4
https://doi.org/10.1158/1078-0432.c.6523757.v1
https://doi.org/10.1158/1078-0432.c.6523757.v1
Autor:
Ludovica, Ciampi, Federica, Mantica, Laura, López-Blanch, Jon, Permanyer, Cristina, Rodriguez-Marín, Jingjing, Zang, Damiano, Cianferoni, Senda, Jiménez-Delgado, Sophie, Bonnal, Samuel, Miravet-Verde, Verena, Ruprecht, Stephan C F, Neuhauss, Sandro, Banfi, Sabrina, Carrella, Luis, Serrano, Sarah A, Head, Manuel, Irimia
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(29)
Retinal photoreceptors have a distinct transcriptomic profile compared to other neuronal subtypes, likely reflecting their unique cellular morphology and function in the detection of light stimuli by way of the ciliary outer segment. We discovered a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::20d26c4067477c5ebe55c3d0389c5599
https://pubmed.ncbi.nlm.nih.gov/35858306
https://pubmed.ncbi.nlm.nih.gov/35858306
Publikováno v:
Bioinformatics
Summary Accurate 3D modelling of protein–protein interactions (PPI) is essential to compensate for the absence of experimentally determined complex structures. Here, we present a new set of commands within the ModelX toolsuite capable of generating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a681f81873a264d0640a053bf8e085f9
https://doi.org/10.1093/bioinformatics/btaa533
https://doi.org/10.1093/bioinformatics/btaa533
Autor:
Manuel Irimia, Violeta Beltran-Sastre, Luis Serrano, Xavier Hernandez-Alias, Martin Schaefer, Ludovica Ciampi, Jae-Seong Yang, Antonio Torres-Méndez, Sarah A. Head
Publikováno v:
PLoS Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Biology, Vol 19, Iss 2, p e3001138 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Biology, Vol 19, Iss 2, p e3001138 (2021)
RNA splicing is widely dysregulated in cancer, frequently due to altered expression or activity of splicing factors (SFs). Microexons are extremely small exons (3–27 nucleotides long) that are highly evolutionarily conserved and play critical roles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8696311190b2d51629f8bdf4e1b17d1
http://hdl.handle.net/10261/249640
http://hdl.handle.net/10261/249640