A mutational and molecular dynamics study of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus: Agonist recognition in the nematode GABA receptor family

Autor: Josh Foster, Everett Cochrane, Mohammad Hassan Khatami, Sarah A. Habibi, Hendrick de Haan, Sean G. Forrester

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 534-539 (2018)

The UNC-49 receptor is a unique nematode γ-aminobutyric acid (GABA)-gated chloride channel that may prove to be a novel target for the development of nematocides. Here we have characterized various charged amino acid residues in and near the agonist

Externí odkaz: https://doaj.org/article/acec6c0167ff4636b3902b68361d8d83

Student Engagement Tracks with Success In-person and Online in a Hybrid-Flexible Course

Autor: Zoya Adeel, Stefan M. Mladjenovic, Sara J. Smith, Pulkit Sahi, Abhay Dhand, Sarah Williams-Habibi, Kate Brown, Katie Moisse

Publikováno v: Canadian Journal for the Scholarship of Teaching and Learning, Vol 14, Iss 2 (2023)

Some university students face barriers to learning in physical classrooms, while others are reluctant to return to in-person learning environments because of COVID-19. Hybrid-flexible (HyFlex) learning environments give students the option to partici

Externí odkaz: https://doaj.org/article/0357f6bdd3d8478b9f0f9da3005d9aa4

Static vs. dynamic methods of delivery for science communication: A critical analysis of user engagement with science on social media

Autor: Lidya Salim, Sarah A. Habibi

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0248507 (2021)
PLoS ONE

Science communication has been increasingly viewed as a necessity and obligation of scientists in recent years. The rise of Web 2.0 technologies, such as social media, has made communication of science to the public more accessible as a whole. While

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e3464fc815794113f2000f82d2b9e3
https://doaj.org/article/f445198482b743369bb333f9c2bc3a7c

Investigating the function and possible biological role of an acetylcholine-gated chloride channel subunit (ACC-1) from the parasitic nematode Haemonchus contortus

Autor: Kristen Nazareth, Wen Jing Law, Richard L. Komuniecki, Sarah A. Habibi, Micah K. Callanan, Sean G. Forrester

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 526-533 (2018)

The cys-loop superfamily of ligand-gated ion channels are well recognized as important drug targets for many invertebrate specific compounds. With the rise in resistance seen worldwide to existing anthelmintics, novel drug targets must be identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e18d93c6e22f025d7382d8002d3ae9
http://europepmc.org/articles/PMC6287539

Molecular Characterization of Binding Loop E in the Nematode Cys-Loop GABA Receptor

Autor: Ariel Kwaka, Hendrick W. de Haan, Everett Cochrane, Joshua Foster, Sean G. Forrester, Sarah A. Habibi, Mohammad Hassan Khatami

Publikováno v: Molecular pharmacology. 94(5)

Nematodes exhibit a vast array of cys-loop ligand-gated ion channels with unique pharmacologic characteristics. However, many of the structural components that govern the binding of various ligands are unknown. The nematode cys-loop GABA receptor unc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af169a1c72a11d2dd1285fd85140b7d
https://pubmed.ncbi.nlm.nih.gov/30194106