Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sarah A. Dorwin"'
Autor:
Tianyuan Zhang, Richard A. G. Smith, Rohinton Edalji, Yu-Gui Gu, John L. Baranowski, William J. Sanders, Bruce A. Beutel, Liping Yu, Philip J. Hajduk, Annapur Gurulingappa Shivakumar, Stephan J. Kakavas, Frank L. Wagenaar, Darlene J. Balli, Steven F. Betz, Richard F. Clark, Kenneth M. Comess, Eric J. Hebert, J. Owen McCall, Jamey Mack, Linda E. Chovan, Randy E. Metzger, Thomas F. Holzman, Anne Y. Saiki, Sarah A. Dorwin, Niru B. Soni, Mai Bui, Angela M. Nilius, Susan J. Thornewell, Cooper Curt S, Mark E. Schurdak, Michael L. Coen, Rolf Wagner, Alan S. Florjancic, Philip J. Merta, Claude G. Lerner, Charlotte Woodall, Candace Black-Schaefer, John E. Harlan, Mengli Cai, Karl A. Walter, Xenia B. Searle, Stephen W. Fesik
Publikováno v:
Chemical Biology & Drug Design. 69:395-404
As part of a fully integrated and comprehensive strategy to discover novel antibacterial agents, NMR- and mass spectrometry-based affinity selection screens were performed to identify compounds that bind to protein targets uniquely found in bacteria
Autor:
James M. Trevillyan, Elizabeth H. Fry, Eric F. Johnson, Chaohong Sun, Hing L. Sham, Charles W. Hutchins, Thomas H. Lubben, Bruce G. Szczepankiewicz, Edward T. Olejniczak, Michael A. Stashko, Cele Abad-Zapatero, Michael D. Serby, Rebecca J. Gum, Hongyu Zhao, Kristi Haskins, Zhili Xin, Bo Liu, Sarah A Dorwin, Jill E. Clampit, Nelson Lissa T, Gang Liu, Mei Liu, Christi Kosogof, Cristina M. Rondinone, Sanyi Wang, Deanna L. Haasch
Publikováno v:
Journal of Medicinal Chemistry. 49:3563-3580
The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family of enzymes. They are activated in response to certain cytokines, as well as by cellular stresses including chemotoxins, peroxides, and i
Autor:
Richard S. Smith, Xumiao Zhao, Aparna V. Sarthy, Vicki L. Nienaber, Kent D. Stewart, Moshe Weitzberg, K. I. Hulkower, Christopher C Butler, Vered Klinghofer, Vincent L. Giranda, Todd W. Rockway, Paul G. Richardson, Sarah A. Dorwin, Michael D. Wendt, Tom Mcgonigal
Publikováno v:
Biochemistry. 40:9125-9131
Inhibition of the proteolytic activity of urokinase has been shown to inhibit the progression of tumors in rodent models and is being investigated for use in human disease. Understanding the rodent/human species-specificity of urokinase inhibitors is
Autor:
Robert C. Goldman, Seth W. Snyder, Tom Mcgonigal, Karl A. Walter, Uri S. Ladror, John O. Capobianco, Sarah A. Dorwin, Rohinton Edalji, David A. Egan, Thomas F. Holzman, Robert W. Johnson, Aparna V. Sarthy
Publikováno v:
Protein Science. 7:2595-2601
Elongation-factor-3 (EF-3) is an essential factor of the fungal protein synthesis machinery. In this communication the structure of EF-3 from Saccharomyces cerevisiae is characterized by differential scanning calorimetry (DSC), ultracentrifugation, a
Autor:
Kimberly A. Klute, Rosalind Helfrich, Robert L. Simmer, Teresa McNally, Donald N. Halbert, Marlon D. Cowart, Elizabeth A. Kowaluk, Kenneth B. Idler, Joseph L. Meuth, Sarah A. Dorwin
Publikováno v:
Biochemical and Biophysical Research Communications. 231:645-650
Adenosine kinase is ubiquitous in eukaryotes and is a key enzyme in the regulation of the intracellular levels of adenosine, an important physiological effector of many cells and tissues. In this paper we report the cloning of cDNAs encoding adenosin
Autor:
Renaldo Mendoza, Andrew M. Petros, Jeffrey R. Huth, Chaohong Sun, Stephen W. Fesik, Saul H. Rosenberg, Karl A. Walter, Philip J. Hajduk, Sarah A. Dorwin, Cheol-Min Park, Wang Xilu, Thorsten Oost, Paul Nimmer, Emily Gramling, Haichao Zhang, Hong Ding, Uri S. Ladror, Steven W. Elmore, Jamey Mack
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(22)
The Bcl-2 family of proteins plays a major role in the regulation of apoptosis, or programmed cell death. Overexpression of the anti-apoptotic members of this family (Bcl-2, Bcl-xL, and Mcl-1) can render cancer cells resistant to chemotherapeutic age
Autor:
Karl A. Walter, Jeffrey R. Huth, Renaldo Mendoza, Sarah A. Dorwin, Jamey Mack, Uri S. Ladror, Danying Song, Philip J. Hajduk, Jean M. Severin, Diane Bartley, Candice L. Black-Schaefer
Publikováno v:
Chemical research in toxicology. 20(12)
We have recently reported on the development of a La assay to detect reactive molecules by nuclear magnetic resonance (ALARM NMR) to detect reactive false positive hits from high-throughput screening, in which we observed a surprisingly large number
Autor:
Stephen W. Fesik, Sarah A. Dorwin, Diane Bartley, Karl A. Walter, Steven W. Elmore, Uri S. Ladror, Jun Chen, Jamey Mack, Sha Jin, Kunzer Aaron R, Russell A. Judge, Paul L. Richardson, Christopher L. Lynch, Philip J. Hajduk, Jean M. Severin, Chang Park, Stephen K. Tahir, Michael D. Wendt, Edward D. Matayoshi, Andrew M. Petros, Jeffrey R. Huth, Wang Xilu, Kerry M. Swift
Publikováno v:
Chemical biologydrug design. 70(1)
The molecular chaperone HSP90 has been shown to facilitate cancer cell survival by stabilizing key proteins responsible for a malignant phenotype. We report here the results of parallel fragment-based drug design approaches in the design of novel HSP
Autor:
Tanveer F. Ahmed, Karl A. Walter, T. F. Holzman, Laura J. Miesbauer, Robert W. Johnson, John E. Harlan, Rohinton Edalji, Sarah A. Dorwin, Richard S. Smith
Publikováno v:
Analytical biochemistry. 341(1)
Fragmentation and "top-down" sequencing of intact proteins by mass spectrometry (MS) is most commonly performed by infusion of protein solutions into Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers. However, the high cost of thi
Autor:
Preston Hill, Jill E. Hochlowski, Michael H. Scherr, James B. McAlpine, David N. Whittern, Ronald R. Rasmussen, Sarah A. Dorwin
Publikováno v:
The Journal of antibiotics. 47(5)
Three novel compounds, named the aselacins, which inhibit the binding of endothelin to its receptor have been isolated from two related Acremonium species of fungi grown in stationary culture. These compounds are cyclic pentapeptolides with a ring fo