Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sarah A Parnell"'
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3739 (2008)
BACKGROUND: Defects in APC and regulatory cells are associated with diabetes development in NOD mice. We have shown previously that NOD APC are not effective at stimulating CD4(+)CD25(+) regulatory cell function in vitro. We hypothesize that failure
Externí odkaz:
https://doaj.org/article/ed2fd53f6af84befb4be0229b3da1966
Publikováno v:
Clinical and Developmental Immunology, Vol 2011 (2011)
Dendritic cells (DCs) from NOD mice produced high levels of IL-12 that induce IFNγ-producing T cells involved in diabetes development. We propose to utilize the microorganism ability to induce tolerogenic DCs to abrogate the proinflammatory process
Externí odkaz:
https://doaj.org/article/2b00b80485ad44f5930b0c2fbab45849
Autor:
Pascale Alard, Sarah A. Parnell, Anita Chhabra, Doreen L. Nebane-Ambe, Colleen F. Tucker, Michele M. Kosiewicz, Yuan Zhao
Publikováno v:
Autoimmunity. 44:453-464
The CD4(+)CD25(+)Foxp3(+) cells are essential for regulation of the immune response, and the integrin, CD103 (α(E)β(7)), identifies a potent subset of these cells. Defects in CD4(+)CD25(+)Foxp3(+) cells are thought to contribute to susceptibility t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e08c55efbc48ce4829e7bce70fb969
https://doi.org/10.3109/08916934.2011.568553
https://doi.org/10.3109/08916934.2011.568553
Publikováno v:
Journal of the Kentucky Academy of Science. 70:145-151
CD4 + CD25 + regulatory cells control the development of autoimmunity, including type 1 diabetes, and the transcription factor Foxp3 is crucial for the development and function of these cells. The decreased effectiveness of regulatory T cell function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bcb71a7220b04df08ea7f7db1d2c1a5
https://doi.org/10.3101/1098-7096-70.2.145
https://doi.org/10.3101/1098-7096-70.2.145
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a27c84a6ba9e6c81196d69196ac4330b
https://doi.org/10.1096/fasebj.22.1_supplement.1074.28
https://doi.org/10.1096/fasebj.22.1_supplement.1074.28
Autor:
Michele M. Kosiewicz, Jean N. Manirarora, Rey A Carabeo, Michael D. Martin, Marine Villard, Sarah A. Parnell, Pascale Alard
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99a39b204ba8185584a2b8855b5c5fb5
https://doi.org/10.1096/fasebj.22.1_supplement.1074.31
https://doi.org/10.1096/fasebj.22.1_supplement.1074.31
Autor:
Sarah A. Parnell, Michele M. Kosiewicz, Jason L. Hudkins, Sherry L. Clark, Jean N. Manirarora, Pascale Alard
Publikováno v:
Diabetes. 55(7)
Various defects in antigen-presenting cells (APCs) and T-cells, including regulatory cells, have been associated with type 1 diabetes development in NOD mice. CD4(+)CD25(+) regulatory cells play a crucial role in controlling various autoimmune diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf31b89304d1feb8135a252bf78af9b4
https://pubmed.ncbi.nlm.nih.gov/16804081
https://pubmed.ncbi.nlm.nih.gov/16804081
Publikováno v:
The Journal of Immunology. 182:99.30-99.30
Females have a higher incidence of autoimmune disease than males. There is a consistently greater disparity in Foxp3+ Treg% between young females and males in autoimmune- vs non-autoimmune prone strains of mice, i.e., lupus-prone BWF1 female mice had
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cdc0a0f920da7a923b4e7132651b7db
https://doi.org/10.4049/jimmunol.182.supp.99.30
https://doi.org/10.4049/jimmunol.182.supp.99.30
Publikováno v:
The Journal of Immunology. 182:48.21-48.21
(NZBxNZW)F1 (BWF1) is a mouse model of SLE in which females develop nephritis by 36 wks. Sick female BWF1 mice have considerably more Foxp3+ Tregs than age-matched non-sick females and males, but these Tregs are unable to control disease. BrdU uptake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90ef06aa4b1d6241d0e3cbe260dd7417
https://doi.org/10.4049/jimmunol.182.supp.48.21
https://doi.org/10.4049/jimmunol.182.supp.48.21
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3739 (2008)
PLoS ONE
PLoS ONE
BACKGROUND: Defects in APC and regulatory cells are associated with diabetes development in NOD mice. We have shown previously that NOD APC are not effective at stimulating CD4(+)CD25(+) regulatory cell function in vitro. We hypothesize that failure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0c6a6c58155f2ba855c88edf7f8d5a
https://doi.org/10.1371/journal.pone.0003739
https://doi.org/10.1371/journal.pone.0003739