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pro vyhledávání: '"Sarah Ludlum"'
Autor:
Javier Gonzalez, Jim Nonomiya, Angelica Linton, Leena Patel, Hui Li, Fannie Chau, Hans E. Parge, Sadayappan V. Rahavendran, Heather Skor, Michael J. Hickey, Tanya Michelle Jewell, Matthew Drowns, Stephanie T. Shi, Robert P. Hunter, Cristina Lewis, Sarah Ludlum, Tatlock John H, Koleen J. Herlihy, Xiu Yu
Publikováno v:
Journal of Medicinal Chemistry. 52:1255-1258
The HCV RNA-dependent RNA polymerase has emerged as one of the key targets for novel anti-HCV therapy development. Herein, we report the optimization of the dihydropyrone series inhibitors to improve compound aqueous solubility and reduce CYP2D6 inhi
Autor:
Tatlock John H, Cristina Lewis, Mel Abreo, Stephanie T. Shi, Michele Yang, Shella A. Fuhrman, Heather Skor, Sarah Ludlum, Tanya Michelle Jewell, Mike Goble, Angelica Linton, Julie Blazel, Allen J. Borchardt, Ravi Rahavendran, Hui Li, Javier Gonzalez, Matthew Drowns, Leena Patel
Publikováno v:
Journal of Medicinal Chemistry. 50:3969-3972
The discovery and optimization of a novel class of carbon-linked dihydropyrones as allosteric HCV NS5B polymerase inhibitors are presented. Replacement of the sulfur linker atom with carbon reduced compound acidity and greatly increased cell permeati
Akademický článek
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Autor:
Hui Li, John Tatlock, Angelica Linton, Javier Gonzalez, Tanya Jewell, Leena Patel, Sarah Ludlum, Matthew Drowns, Sadayappan V. Rahavendran, Heather Skor, Robert Hunter, Stephanie T. Shi, Koleen J. Herlihy, Hans Parge, Michael Hickey, Xiu Yu, Fannie Chau, Jim Nonomiya, Cristina Lewis
Publikováno v:
Journal of Medicinal Chemistry; Mar2009, Vol. 52 Issue 5, p1255-1258, 4p
Autor:
Hui Li, Angelica Linton, John Tatlock, Javier Gonzalez, Allen Borchardt, Mel Abreo, Tanya Jewell, Leena Patel, Matthew Drowns, Sarah Ludlum, Mike Goble, Michele Yang, Julie Blazel, Ravi Rahavendran, Heather Skor, Stephanie Shi, Cristina Lewis, Shella Fuhrman
Publikováno v:
Journal of Medicinal Chemistry; Aug2007, Vol. 50 Issue 17, p3969-3972, 4p