Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sarah Hanrahan"'
Autor:
Namir J. Hassan, A N Barclay, Sarah Hanrahan, Marion H. Brown, Nicholas G. Clarkson, M Bomb, Stephen J. Simmonds, M J Puklavec
Publikováno v:
Molecular and cellular biology. 39(7)
Deciphering the role of lymphocyte membrane proteins depends on dissecting the role of a protein in the steady state and on engagement with its ligand. We show that expression of CD6 in T cells limits their responsiveness but that engagement by the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be5f9f4f0450731fe5a3ea58b820503
https://pubmed.ncbi.nlm.nih.gov/16914752
https://pubmed.ncbi.nlm.nih.gov/16914752
Autor:
David E. Neal, Karin Barnouin, Sarah Hanrahan, Nick Totty, Hayley C. Whitaker, Gavin Kelly, Hayley J. Luxton
Publikováno v:
Molecular Oncology
The pivotal role of LYRIC/AEG‐1 in malignant transformation, tumourigenesis and chemo‐resistance has previously been demonstrated in different cell types and sub‐cellular compartments. The localisation of LYRIC/AEG‐1 appears crucial to its fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2164075ed7731fe217438004268850f9
https://doi.org/10.1016/j.molonc.2014.01.009
https://doi.org/10.1016/j.molonc.2014.01.009
Autor:
Nora Cronin, David Barford, Andrew J. Thompson, Ioannis Manolaridis, Kiran Kulkarni, Ziguo Zhang, Sarah Hanrahan, Ganka Bineva, Roger B. Dodd, Satoshi Ogasawara, So Iwata, Nicola O’Reilly
Publikováno v:
Nature
CAAX proteins have essential roles in multiple signalling pathways, controlling processes such as proliferation, differentiation and carcinogenesis. The ∼120 mammalian CAAX proteins function at cellular membranes and include the Ras superfamily of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b97b0001a09954ebb22ada54c51c18
https://doi.org/10.1038/nature12754
https://doi.org/10.1038/nature12754
Publikováno v:
Nature Structural & Molecular Biology. 17:726-731
The maturation of human RET is adversely affected by a range of missense mutations found in patients with Hirschsprung's disease (HSCR), a complex multigenic disease. Here we show that two N-terminal cadherin-like domains, CLD1 and CLD2 (CLD(1-2)), f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f220cfa2fa091cefb37d276a76e64f
https://doi.org/10.1038/nsmb.1808
https://doi.org/10.1038/nsmb.1808
Autor:
M. Shafiq, M. Collister, Nick Totty, Robin J. Dickinson, Gavin C. Fox, David Briggs, Sarah Hanrahan, Stephen M. Keyse, Michael J. R. Stark, Neil Q. McDonald, Vasso Makrantoni, Philip P. Knowles, M. J. Didmon
Publikováno v:
Nature. 447:487-492
The stress-induced yeast MAPK phosphatase Sdp1 acquires enhanced activity under oxidative conditions by forming an intramolecular disulphide bond that is used to recognize a tyrosine-phosphorylated substrate. Reactive oxygen species trigger cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732e5d81ba6a6ca8575c4bae817df84f
https://doi.org/10.1038/nature05804
https://doi.org/10.1038/nature05804
Autor:
Giampietro Schiavo, Sarah Hanrahan, Cecilia Bucci, Carole Verastegui, Daniel Worth, Katrin Deinhardt, Sara Salinas, Rose Watson
Publikováno v:
Neuron. 52(2):293-305
Vesicular pathways coupling the neuromuscular junction with the motor neuron soma are essential for neuronal function and survival. To characterize the organelles responsible for this long-distance crosstalk, we developed a purification strategy base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6894ae1e49e2155e38aa8094029cf7
Autor:
Tuncay Kayademir, Rosemary Jeffery, Nikolaus Blin, Chung-Yin Lee, Ketan Patel, Sarah Hanrahan, Marissa D. Evans, Fiona McGregor, Nicholas A. Wright, Richard Poulsom, Kenneth Blight, Karin A. Oien, Iain McKinnell, Toby Hunt, David Frith, William R. Otto
Publikováno v:
PROTEOMICS. 6:4235-4245
The trefoil factor family (TFF) peptides are important in gastro-intestinal mucosal protection and repair. Their mechanism of action remains unclear and receptors are sought. We aimed to identify and characterise proteins binding to TFF2. A fusion pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94317ed655ac2aee6b64f25b0bdf225e
https://doi.org/10.1002/pmic.200500911
https://doi.org/10.1002/pmic.200500911
Autor:
Adrian L. Harris, William S. Trimble, Eamonn R. Maher, Nick Totty, Sarah Hanrahan, Anthea J. Stanley, Patricia Harnden, Rachel A. Craven, Peter Selby, Rosamonde E. Banks
Publikováno v:
PROTEOMICS. 6:3880-3893
The von Hippel Lindau (VHL) tumour suppressor gene, VHL, plays a central role in development of sporadic conventional renal cell carcinomas (RCCs). Studying VHL function may, therefore, increase understanding of the pathogenesis of RCC and identify m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0187b8db0e2440858e5ec4165d48cb18
https://doi.org/10.1002/pmic.200500811
https://doi.org/10.1002/pmic.200500811
Autor:
Rosamonde E. Banks, Sarah Hanrahan, James Dods, Nick Totty, Anthea J. Stanley, Richard D. Unwin, Patricia Harnden, Ian Eardley, Rachel A. Craven, Peter Selby
Publikováno v:
PROTEOMICS. 6:2853-2864
New markers/targets for renal cell carcinoma (RCC) are needed to enable earlier detection and monitoring of disease and therapeutic targeting. To identify such molecules, normal and RCC-derived primary cell lines have been used as a simplified model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec87b67c77d3e90a4b6abe0d58b4e93f
https://doi.org/10.1002/pmic.200500549
https://doi.org/10.1002/pmic.200500549
Autor:
Rosamonde E. Banks, Sarah Hanrahan, Nick Totty, Rainy Mears, Peter Selby, Poulam M. Patel, Sarah L. Young, Carol Upton, Rachel A. Craven
Publikováno v:
PROTEOMICS. 4:4019-4031
Exosomes are 40-100 nm vesicles released by numerous cell types and are thought to have a variety of roles depending on their origin. Exosomes derived from antigen presenting cells have been shown to be capable of initiating immune responses in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33f0c378c160ff9dc2b1cd53a6cacac
https://doi.org/10.1002/pmic.200400876
https://doi.org/10.1002/pmic.200400876