Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sarah, Welbourn"'
Autor:
Rohini Mopuri, Sarah Welbourn, Tysheena Charles, Pooja Ralli-Jain, David Rosales, Samantha Burton, Areeb Aftab, Kirti Karunakaran, Kathryn Pellegrini, William Kilembe, Etienne Karita, Sandrasegaram Gnanakaran, Amit A Upadhyay, Steven E Bosinger, Cynthia A Derdeyn
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011717 (2023)
A protective HIV-1 vaccine has been hampered by a limited understanding of how B cells acquire neutralizing activity. Our previous vaccines expressing two different HIV-1 envelopes elicited robust antigen specific serum IgG titers in 20 rhesus macaqu
Externí odkaz:
https://doaj.org/article/1134d83f0e044f18b5105af8a940f58d
Autor:
Tiffany M. Styles, Sailaja Gangadhara, Pradeep B. J. Reddy, Anusmita Sahoo, Ayalensh Shiferaw, Sarah Welbourn, Pamela A. Kozlowski, Cynthia A. Derdeyn, Vijayakumar Velu, Rama Rao Amara
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Stabilized HIV envelope (Env) trimeric protein immunogens have been shown to induce strong autologous neutralizing antibody response. However, there is limited data on the immunogenicity and efficacy of stabilized Env expressed by a viral vector-base
Externí odkaz:
https://doaj.org/article/81f9a87b6bff43e3a8a1399b0ad63c82
Autor:
Sarah Welbourn, Srirupa Chakraborty, Jie E Yang, Anne S Gleinich, Sailaja Gangadhara, Salar Khan, Courtney Ferrebee, Bhrugu Yagnik, Samantha Burton, Tysheena Charles, S Abigail Smith, Danielle Williams, Rohini Mopuri, Amit A Upadhyay, Justin Thompson, Matt A Price, Shiyu Wang, Zhaohui Qin, Xiaoying Shen, LaTonya D Williams, Nathan Eisel, Tiffany Peters, Lu Zhang, William Kilembe, Etienne Karita, Georgia D Tomaras, Steven E Bosinger, Rama R Amara, Parastoo Azadi, Elizabeth R Wright, Sandrasegaram Gnanakaran, Cynthia A Derdeyn
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010488 (2022)
Transmitted/founder (T/F) HIV-1 envelope proteins (Envs) from infected individuals that developed neutralization breadth are likely to possess inherent features desirable for vaccine immunogen design. To explore this premise, we conducted an immuniza
Externí odkaz:
https://doaj.org/article/57b66c8bac8a49fbb543e6148e785893
Autor:
Maria Pino, Susan Pereira Ribeiro, Amélie Pagliuzza, Khader Ghneim, Anum Khan, Emily Ryan, Justin L Harper, Colin T King, Sarah Welbourn, Luca Micci, Sol Aldrete, Keith A Delman, Theron Stuart, Michael Lowe, Jason M Brenchley, Cynthia A Derdeyn, Kirk Easley, Rafick P Sekaly, Nicolas Chomont, Mirko Paiardini, Vincent C Marconi
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009825 (2021)
Clinical outcomes are inferior for individuals with HIV having suboptimal CD4 T-cell recovery during antiretroviral therapy (ART). We investigated if the levels of infection and the response to homeostatic cytokines of CD4 T-cell subsets contributed
Externí odkaz:
https://doaj.org/article/067e37f438b34fd7827433be61b176ba
Autor:
Carolyn A. Robinson, Terri D. Lyddon, Hwi Min Gil, David T. Evans, Yury V. Kuzmichev, Jonathan Richard, Andrés Finzi, Sarah Welbourn, Lynn Rasmussen, N. Miranda Nebane, Vandana V. Gupta, Sam Ananthan, Zhaohui Cai, Elizabeth R. Wonderlich, Corinne E. Augelli-Szafran, Robert Bostwick, Roger G. Ptak, Susan M. Schader, Marc C. Johnson
Publikováno v:
Viruses, Vol 14, Iss 4, p 817 (2022)
HIV-1 Vpu targets the host cell proteins CD4 and BST-2/Tetherin for degradation, ultimately resulting in enhanced virus spread and host immune evasion. The discovery and characterization of small molecules that antagonize Vpu would further elucidate
Externí odkaz:
https://doaj.org/article/cb9aa0928f724cc5b71172c99af2a758
Autor:
Paige R Gruenke, Rachna Aneja, Sarah Welbourn, Obiaara B Ukah, Stefan G Sarafianos, Donald H Burke, Margaret J Lange
Publikováno v:
Nucleic acids research. 50(3)
The HIV-1 capsid core participates in several replication processes. The mature capsid core is a lattice composed of capsid (CA) monomers thought to assemble first into CA dimers, then into ∼250 CA hexamers and 12 CA pentamers. CA assembly requires
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70cbb191520ac740533f62eeae65dbb
https://pubmed.ncbi.nlm.nih.gov/35018437
https://pubmed.ncbi.nlm.nih.gov/35018437
Autor:
Masashi Shingai, Sarah Welbourn, Jason M Brenchley, Priyamvada Acharya, Eri Miyagi, Ronald J Plishka, Alicia Buckler-White, Peter D Kwong, Yoshiaki Nishimura, Klaus Strebel, Malcolm A Martin
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004928 (2015)
For nearly 20 years, the principal biological function of the HIV-2/SIV Vpx gene has been thought to be required for optimal virus replication in myeloid cells. Mechanistically, this Vpx activity was recently reported to involve the degradation of St
Externí odkaz:
https://doaj.org/article/7382312e0a5a4f02aaf32f1c7b3281aa
Autor:
N. Miranda Nebane, Yury V Kuzmichev, Elizabeth R. Wonderlich, Marc C. Johnson, Jonathan Richard, Susan M. Schader, Sarah Welbourn, Andrés Finzi, Corinne E. Augelli-Szafran, Vandana V. Gupta, Roger G. Ptak, Terri D. Lyddon, Carolyn A. Robinson, Robert Bostwick, Hwi Min Gil, Zhaohui Cai, Sam Ananthan, Lynn Rasmussen, David T. Evans
HIV-1 Vpu targets the host cell proteins CD4 and BST-2/Tetherin for degradation, ultimately resulting in enhanced virus spread and host immune evasion. The discovery and characterization of small molecules that antagonize Vpu would further elucidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09ea728eb1d665c2ecfc789c351c71ad
https://doi.org/10.1101/2021.07.30.454560
https://doi.org/10.1101/2021.07.30.454560
Autor:
Theron Stuart, Susan Pereira Ribeiro, Nicolas Chomont, Emily S. Ryan, Vincent C. Marconi, Justin L. Harper, Amélie Pagliuzza, Rafick Pierre Sekaly, Cynthia A. Derdeyn, Sol del Mar Aldrete, Luca Micci, Sarah Welbourn, Jason M. Brenchley, Keith A. Delman, Mirko Paiardini, Kirk Easley, Maria Pino, Anum Khan, Michael C. Lowe, Khader Ghneim, Colin T. King
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 8, p e1009825 (2021)
PLoS Pathogens, Vol 17, Iss 8, p e1009825 (2021)
Clinical outcomes are inferior for individuals with HIV having suboptimal CD4 T-cell recovery during antiretroviral therapy (ART). We investigated if the levels of infection and the response to homeostatic cytokines of CD4 T-cell subsets contributed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3154e42975239cdf4acc6ddbd381b78
http://europepmc.org/articles/PMC8397407
http://europepmc.org/articles/PMC8397407
Publikováno v:
J Virol
Vif counteracts the host restriction factor APOBEC3G (A3G) and other APOBEC3s by preventing the incorporation of A3G into progeny virions. We previously identified Vif mutants with a dominant-negative (D/N) phenotype that interfered with the function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8fceb3b32c897f4b949004d2598a3a
https://pubmed.ncbi.nlm.nih.gov/31941780
https://pubmed.ncbi.nlm.nih.gov/31941780