Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sarah, Tsao"'
Publikováno v:
The FEBS Journal. 288:3478-3506
Candida albicans is a pathogenic fungus that causes systemic infections and mortality in immunosuppressed individuals. We previously showed that deacetylation of histone H3 lysine 56 by Hst3 is essential for C. albicans viability. Hst3 is a fungal-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eefd629afeacfb8d7906c04f769673c
https://doi.org/10.1111/febs.15622
https://doi.org/10.1111/febs.15622
Autor:
Caroline Huard, Michael A. Cook, Almer M. van der Sloot, Pierre Thibault, Eric Bonneil, Jasmin Coulombe-Huntington, Thierry Bertomeu, Daniel Pallant, Elizabeth J. Culp, Gerard D. Wright, Mike Tyers, Samuel Jacques, Sarah Tsao, Sylvain Tollis
Publikováno v:
Genetics
The imipridones ONC201 and ONC212 selectively kill cancer cells and have been ascribed multiple mechanisms-of-action. Genome-wide CRISPR knockout screens revealed that loss of the mitochondrial proteases CLPP and MIPEP confer strong resistance to bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a78b7ef92e4cb9bc100775087ac72f
https://doi.org/10.1534/genetics.119.302851
https://doi.org/10.1534/genetics.119.302851
Autor:
Emmanuel D. Levy, Tong Shu, Meta Heidenreich, Matheus P. Viana, Dajun Sang, Liam J. Holt, Jonathan Alberts, Sarah Tsao
Publikováno v:
Biophysical Journal. 120:31a-32a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d64665b563479330a2393450034a8e32
https://doi.org/10.1016/j.bpj.2020.11.445
https://doi.org/10.1016/j.bpj.2020.11.445
Autor:
Christine Cameron, Elaheh Ahmadzadeh, Sandra Weber, Dominic Nehme, Martine Raymond, Sarah Tsao
Publikováno v:
Journal of Antimicrobial Chemotherapy. 71:3125-3134
Objectives Overexpression of ATP-binding cassette (ABC) transporters is a frequent cause of multidrug resistance in cancer cells and pathogenic microorganisms. One example is the Cdr1p transporter from the human fungal pathogen Candida albicans that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f52e13b52527600b7c391915b9c342c
https://doi.org/10.1093/jac/dkw252
https://doi.org/10.1093/jac/dkw252
Autor:
Brian C. Monk, Koichi Tanabe, Yoshimasa Uehara, Masakazu Niimi, Ann R. Holmes, Erwin Lamping, Kyoko Niimi, Richard D. Cannon, Sarah Tsao
Publikováno v:
Eukaryotic Cell. 6:1150-1165
The study of eukaryotic membrane proteins has been hampered by a paucity of systems that achieve consistent high-level functional protein expression. We report the use of a modified membrane protein hyperexpression system to characterize three classe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0654df3f349bc70ac0afeb1f54d89cf9
https://doi.org/10.1128/ec.00091-07
https://doi.org/10.1128/ec.00091-07
Publikováno v:
Journal of cell science. 128(19)
Graduate students and postdoctoral fellows at the Institute for Research in Immunology and Cancer (IRIC) organized the 9th IRIC International Symposium on 14–15 May, 2015. The symposium was held at the IRIC, an ultra-modern research hub and trainin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3965e0560173881993e4c24435ca3f0
https://pubmed.ncbi.nlm.nih.gov/26430202
https://pubmed.ncbi.nlm.nih.gov/26430202
Autor:
Richard D. Cannon, Barbara R. Holland, Brian C. Monk, Soo-Wee Ong, Sarah Tsao, Aki Kaneko, Jan Schmid, Erwin Lamping, Kyoko Niimi, Ann R. Holmes, Masakazu Niimi
Publikováno v:
Molecular Microbiology. 62:170-186
Summary Elevated expression of the plasma membrane drug efflux pump proteins Cdr1p and Cdr2p was shown to accompany decreased azole susceptibility in Candida albicans clinical isolates. DNA sequence analysis revealed extensive allelic heterozygosity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800744688883c755bcb55cfba6cfeabd
https://doi.org/10.1111/j.1365-2958.2006.05357.x
https://doi.org/10.1111/j.1365-2958.2006.05357.x
Autor:
Richard D. Cannon, Koichi Tanabe, Masakazu Niimi, Ann R. Holmes, Brian C. Monk, Erwin Lamping, Sarah Tsao, Kyoko Niimi
Publikováno v:
Nippon Ishinkin Gakkai Zasshi. 47:275-281
Membrane-located drug transporters are important components in the multidrug resistance of microbial cells and human tissues. In fungi, clinically important resistance to antifungal drugs most often results from the over-expression of efflux pump pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8b1fd97fd4940e5402e72e32b246be
https://doi.org/10.3314/jjmm.47.275
https://doi.org/10.3314/jjmm.47.275
Autor:
Jonas F. Dorn, Edlie St-Hilaire, Hugo Wurtele, Philippe Pasero, Julien Bacal, Gitte Schalck Kaiser, Michael Lisby, Paul S. Maddox, Eun Hye Lee, Alain Verreault, Sarah Tsao
Publikováno v:
Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2012, 32 (1), pp.154-172. ⟨10.1128/MCB.05415-11⟩
Molecular and Cellular Biology, American Society for Microbiology, 2012, 32 (1), pp.154-172. ⟨10.1128/MCB.05415-11⟩
In Saccharomyces cerevisiae, histone H3 lysine 56 acetylation (H3K56ac) occurs in newly synthesized histones that are deposited throughout the genome during DNA replication. Defects in H3K56ac sensitize cells to genotoxic agents, suggesting that this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6bd755836d0e32be48149a1f923b1d
https://europepmc.org/articles/PMC3255698/
https://europepmc.org/articles/PMC3255698/
Autor:
Martine Raymond, Paul Drogaris, Alaka Mullick, Guylaine Lépine, Eun Hye Lee, Alain Verreault, Hugo Wurtele, Pierre Thibault, Sarah Tsao, Jessy Tremblay
Candida albicans is a major fungal pathogen that causes serious systemic and mucosal infections in immunocompromised individuals. In yeast, histone H3 Lys56 acetylation (H3K56ac) is an abundant modification regulated by enzymes that have fungal-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294a98d4df458a94727428ece8f12c86
https://europepmc.org/articles/PMC4108442/
https://europepmc.org/articles/PMC4108442/