Molecular characterization of gliomas and glioneuronal tumors amid Noonan syndrome: cancer predisposition examined

Autor: Margaret Shatara, Kathleen M. Schieffer, Marilena Melas, Elizabeth A. Varga, Diana Thomas, Brianna A. Bucknor, Heather M. Costello, Gregory Wheeler, Benjamin J. Kelly, Katherine E. Miller, Diana P. Rodriguez, Mariam T. Mathew, Kristy Lee, Erin Crotty, Sarah Leary, Vera A. Paulson, Bonnie Cole, Mohamed S. Abdelbaki, Jonathan L. Finlay, Margot A. Lazow, Ralph Salloum, Maryam Fouladi, Daniel R. Boué, Elaine R. Mardis, Catherine E. Cottrell

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

IntroductionIn the setting of pediatric and adolescent young adult cancer, increased access to genomic profiling has enhanced the detection of genetic variation associated with cancer predisposition, including germline syndromic conditions. Noonan sy

Externí odkaz: https://doaj.org/article/3f7187b0ada1421ea4a77df0475dfdd6

The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science

Autor: Jena V. Lilly, Jo Lynne Rokita, Jennifer L. Mason, Tatiana Patton, Stephanie Stefankiewiz, David Higgins, Gerri Trooskin, Carina A. Larouci, Kamnaa Arya, Elizabeth Appert, Allison P. Heath, Yuankun Zhu, Miguel A. Brown, Bo Zhang, Bailey K. Farrow, Shannon Robins, Allison M. Morgan, Thinh Q. Nguyen, Elizabeth Frenkel, Kaitlin Lehmann, Emily Drake, Catherine Sullivan, Alexa Plisiewicz, Noel Coleman, Luke Patterson, Mateusz Koptyra, Zeinab Helili, Nicholas Van Kuren, Nathan Young, Meen Chul Kim, Christopher Friedman, Alex Lubneuski, Christopher Blackden, Marti Williams, Valerie Baubet, Lamiya Tauhid, Jamie Galanaugh, Katie Boucher, Heba Ijaz, Kristina A. Cole, Namrata Choudhari, Mariarita Santi, Robert W. Moulder, Jonathan Waller, Whitney Rife, Sharon J. Diskin, Marion Mateos, Donald W. Parsons, Ian F. Pollack, Stewart Goldman, Sarah Leary, Chiara Caporalini, Anna Maria Buccoliero, Mirko Scagnet, David Haussler, Derek Hanson, Ron Firestein, Jason Cain, Joanna J. Phillips, Nalin Gupta, Sabine Mueller, Gerald Grant, Michelle Monje-Deisseroth, Sonia Partap, Jeffrey P. Greenfield, Rintaro Hashizume, Amy Smith, Shida Zhu, James M. Johnston, Jason R. Fangusaro, Matthew Miller, Matthew D. Wood, Sharon Gardner, Claire L. Carter, Laura M. Prolo, Jared Pisapia, Katherine Pehlivan, Andrea Franson, Toba Niazi, Josh Rubin, Mohamed Abdelbaki, David S. Ziegler, Holly B. Lindsay, Ana Guerreiro Stucklin, Nicolas Gerber, Olena M. Vaske, Carolyn Quinsey, Brian R. Rood, Javad Nazarian, Eric Raabe, Eric M. Jackson, Stacie Stapleton, Robert M. Lober, David E. Kram, Carl Koschmann, Phillip B. Storm, Rishi R. Lulla, Michael Prados, Adam C. Resnick, Angela J. Waanders

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 35, Iss , Pp 100846- (2023)

Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term

Externí odkaz: https://doaj.org/article/ccba034296a747dd98510c07ca0814c3

Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma

Autor: Liana Nobre, Michal Zapotocky, Sara Khan, Kohei Fukuoka, Adriana Fonseca, Tara McKeown, David Sumerauer, Ales Vicha, Wieslawa A. Grajkowska, Joanna Trubicka, Kay Ka Wai Li, Ho-Keung Ng, Luca Massimi, Ji Yeoun Lee, Seung-Ki Kim, Shayna Zelcer, Alexandre Vasiljevic, Cécile Faure-Conter, Peter Hauser, Boleslaw Lach, Marie-Lise van Veelen-Vincent, Pim J. French, Erwin G. Van Meir, William A. Weiss, Nalin Gupta, Ian F. Pollack, Ronald L. Hamilton, Amulya A. Nageswara Rao, Caterina Giannini, Joshua B. Rubin, Andrew S. Moore, Lola B. Chambless, Rajeev Vibhakar, Young Shin Ra, Maura Massimino, Roger E. McLendon, Helen Wheeler, Massimo Zollo, Veronica Ferruci, Toshihiro Kumabe, Claudia C. Faria, Jaroslav Sterba, Shin Jung, Enrique López-Aguilar, Jaume Mora, Carlos G. Carlotti, James M. Olson, Sarah Leary, Jason Cain, Lenka Krskova, Josef Zamecnik, Cynthia E. Hawkins, Uri Tabori, Annie Huang, Ute Bartels, Paul A. Northcott, Michael D. Taylor, Stephen Yip, Jordan R. Hansford, Eric Bouffet, Vijay Ramaswamy

Publikováno v: Cell Reports Medicine, Vol 1, Iss 3, Pp 100038- (2020)

Summary: Over the past decade, wingless-activated (WNT) medulloblastoma has been identified as a candidate for therapy de-escalation based on excellent survival; however, a paucity of relapses has precluded additional analyses of markers of relapse.

Externí odkaz: https://doaj.org/article/fe064d5dfe04450eab73d80ac7fe7dce

Matrix Hyaluronic Acid and Hypoxia Influence a CD133

Autor: Jee-Wei Emily, Chen, Sarah, Leary, Victoria, Barnhouse, Jann N, Sarkaria, Brendan A C, Harley

Publikováno v: Tissue Eng Part A

Glioblastoma (GBM) displays diffusive invasion throughout the brain microenvironment, which is partially responsible for its short median survival rate (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b0079486346b7e1ee59e80523f78f6f
https://pubmed.ncbi.nlm.nih.gov/34435883

Volumetric endpoints in diffuse intrinsic pontine glioma: comparison to cross-sectional measures and outcome correlations in the International DIPG/DMG Registry

Autor: Margot A Lazow, Martijn T Nievelstein, Adam Lane, Pratiti Bandopadhayhay, Mariko DeWire-Schottmiller, Maryam Fouladi, John W Glod, Robert J Greiner, Lindsey M Hoffman, Trent R Hummel, Lindsay Kilburn, Sarah Leary, Jane E Minturn, Roger Packer, David S Ziegler, Brooklyn Chaney, Katie Black, Peter de Blank, James L Leach

Publikováno v: Neuro Oncol

Background Cross-sectional tumor measures are traditional clinical trial endpoints; however volumetric measures may better assess tumor growth. We determined the correlation and compared the prognostic impact of cross-sectional and volumetric measure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5972d7a65cd6e19da61b6338e60c72e9
https://doi.org/10.1093/neuonc/noac037