Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Sarah, Kitson"'
Autor:
Rhona J McVey, Kássio M. G. Lima, Helena O'Flynn, Emma J Crosbie, Sarah Kitson, Abigail E. Derbyshire, Cecilia Pow, Pierre L. Martin-Hirsch, Maria Paraskevaidi, Olivia Raglan, Katherine M. Ashton, Vanitha N Sivalingam, Helen F. Stringfellow, Camilo L. M. Morais, Maria Kyrgiou, Neil A J Ryan, Francis Martin, Michelle L. MacKintosh
Publikováno v:
Paraskevaidi, M, Morais, C L M, Ashton, K, Stringfellow, H, McVey, R J, Ryan, N, O'Flynn, H, Sivalingam, V, Kitson, S, Mackintosh, M, Derbyshire, A, Pow, C, Raglan, O, Lima, K M G, Kyrgiou, M, Martin-Hirsch, P L, Martin, F & Crosbie, E 2020, ' Detecting endometrial cancer by blood spectroscopy: A diagnostic cross-sectional study ', Cancers, vol. 12, no. 5, 1256 . https://doi.org/10.3390/cancers12051256
Cancers, Vol 12, Iss 1256, p 1256 (2020)
Cancers
Volume 12
Issue 5
Paraskevaidi, M, Morais, C L M, Ashton, K M, Stringfellow, H F, McVey, R J, Ryan, N, O'Flynn, H, Sivalingam, V N, Kitson, S J, MacKintosh, M L, Derbyshire, A E, Pow, C, Raglan, O, Lima, K M G, Kyrgiou, M, Martin-Hirsch, P L, Martin, F L & Crosbie, E J 2020, ' Detecting Endometrial Cancer by Blood Spectroscopy : A Diagnostic Cross-Sectional Study ', Cancers, vol. 12, no. 5, 1256 . https://doi.org/10.3390/cancers12051256
Paraskevaidi, M, Morais, C L M, Ashton, K M, Stringfellow, H F, McVey, R J, Ryan, N A J, O'Flynn, H, Sivalingam, V N, Kitson, S J, MacKintosh, M L, Derbyshire, A E, Pow, C, Raglan, O, Lima, K M G, Kyrgiou, M, Martin-Hirsch, P L, Martin, F L & Crosbie, E J 2020, ' Detecting Endometrial Cancer by Blood Spectroscopy : A Diagnostic Cross-Sectional Study ', Cancers, vol. 12, no. 5, 1256 . https://doi.org/10.3390/cancers12051256
Cancers, Vol 12, Iss 1256, p 1256 (2020)
Cancers
Volume 12
Issue 5
Paraskevaidi, M, Morais, C L M, Ashton, K M, Stringfellow, H F, McVey, R J, Ryan, N, O'Flynn, H, Sivalingam, V N, Kitson, S J, MacKintosh, M L, Derbyshire, A E, Pow, C, Raglan, O, Lima, K M G, Kyrgiou, M, Martin-Hirsch, P L, Martin, F L & Crosbie, E J 2020, ' Detecting Endometrial Cancer by Blood Spectroscopy : A Diagnostic Cross-Sectional Study ', Cancers, vol. 12, no. 5, 1256 . https://doi.org/10.3390/cancers12051256
Paraskevaidi, M, Morais, C L M, Ashton, K M, Stringfellow, H F, McVey, R J, Ryan, N A J, O'Flynn, H, Sivalingam, V N, Kitson, S J, MacKintosh, M L, Derbyshire, A E, Pow, C, Raglan, O, Lima, K M G, Kyrgiou, M, Martin-Hirsch, P L, Martin, F L & Crosbie, E J 2020, ' Detecting Endometrial Cancer by Blood Spectroscopy : A Diagnostic Cross-Sectional Study ', Cancers, vol. 12, no. 5, 1256 . https://doi.org/10.3390/cancers12051256
Endometrial cancer is the sixth most common cancer in women, with a rising incidence worldwide. Current approaches for the diagnosis and screening of endometrial cancer are invasive, expensive or of moderate diagnostic accuracy, limiting their clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ade4950325ce9d351c6ffb0e89bed7
https://doi.org/10.3390/cancers12051256
https://doi.org/10.3390/cancers12051256
Autor:
James Bolton, Neil A J Ryan, Sarah Kitson, Fiona Lalloo, D. Gareth Evans, Richard J. Edmondson, Emma J Crosbie, Richard D Clayton, Emma R. Woodward, Cemsel Bafligil
Publikováno v:
European Journal of Cancer
Kitson, S, Bafligil, C, Ryan, N, Lalloo, F, Woodward, E, Clayton, R, Edmondson, R, Bolton, J, Crosbie, E & Evans, D G 2020, ' BRCA1 and BRCA2 pathogenic variant carriers and endometrial cancer risk-a cohort study ', European Journal of Cancer, vol. 136, pp. 169-175 . https://doi.org/10.1016/j.ejca.2020.05.030
Kitson, S J, Bafligil, C, Ryan, N A J, Lalloo, F, Woodward, E R, Clayton, R D, Edmondson, R J, Bolton, J, Crosbie, E J & Evans, D G 2020, ' BRCA1 and BRCA2 pathogenic variant carriers and endometrial cancer risk : A cohort study ', European Journal of Cancer, vol. 136, pp. 169-175 . https://doi.org/10.1016/j.ejca.2020.05.030
Kitson, S, Bafligil, C, Ryan, N, Lalloo, F, Woodward, E, Clayton, R, Edmondson, R, Bolton, J, Crosbie, E & Evans, D G 2020, ' BRCA1 and BRCA2 pathogenic variant carriers and endometrial cancer risk-a cohort study ', European Journal of Cancer, vol. 136, pp. 169-175 . https://doi.org/10.1016/j.ejca.2020.05.030
Kitson, S J, Bafligil, C, Ryan, N A J, Lalloo, F, Woodward, E R, Clayton, R D, Edmondson, R J, Bolton, J, Crosbie, E J & Evans, D G 2020, ' BRCA1 and BRCA2 pathogenic variant carriers and endometrial cancer risk : A cohort study ', European Journal of Cancer, vol. 136, pp. 169-175 . https://doi.org/10.1016/j.ejca.2020.05.030
Background An association between BRCA pathogenic variants and an increased endometrial cancer risk, specifically serous-like endometrial cancer, has been postulated but remains unproven, particularly for BRCA2 carriers. Mechanistic evidence is lacki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a24e53d20102bde427db8ff41617e69
https://pubmed.ncbi.nlm.nih.gov/32698099
https://pubmed.ncbi.nlm.nih.gov/32698099
Publikováno v:
Sivalingam, V N, Kitson, S, MacKintosh, M L, Rutter, M K & Crosbie, E J 2020, ' Interventions to improve insulin resistance for the prevention of endometrial cancer ', Cochrane Database of Systematic Reviews, vol. 2020, no. 1, CD013523 . https://doi.org/10.1002/14651858.CD013523
Cochrane Database Syst Rev
Cochrane Database Syst Rev
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:. To determine the safety and effectiveness of interventions to improve insulin resistance for the prevention of atypical endometrial hyperplasia or endometrial ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb648d3815019877b4c49970a4de44c
https://doi.org/10.1002/14651858.cd013523
https://doi.org/10.1002/14651858.cd013523
Autor:
Katherine G. Finegan, Ayse Latif, Emma J Crosbie, Rhona J McVey, Ian J. Stratford, Michael P. Lisanti, Sarah Kitson, Vanitha N Sivalingam, Kay Marshall, Federica Sotgia
Publikováno v:
Sivalingam, V, Latif, A, Kitson, S, McVey, R J, Finegan, K, Marshall, K, Lisanti, M P, Sotgia, F, Stratford, I & Crosbie, E 2020, ' Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin ', British Journal of Cancer, vol. 122, 122, pp. 62-71 . https://doi.org/10.1038/s41416-019-0627-y
British Journal of Cancer
British Journal of Cancer
BackgroundHigh expression of Ki67, a proliferation marker, is associated with reduced endometrial cancer-specific survival. Pre-surgical metformin reduces tumour Ki-67 expression in some women with endometrial cancer. Metformin’s anti-cancer activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc98bfe7dc94b4fc57fb7489f2c1d12
https://research.manchester.ac.uk/en/publications/6f3a6797-e5b4-42bb-91e5-995025195ae9
https://research.manchester.ac.uk/en/publications/6f3a6797-e5b4-42bb-91e5-995025195ae9
Autor:
Hannah J. Gregson, Kay Marshall, Stephen A Roberts, Sarah Kitson, Vanitha N Sivalingam, Kaye J. Williams, Amy L. Chadwick, James Bolton, Ayse Latif, Emma J Crosbie, Rhona J McVey, Ian J. Stratford
Publikováno v:
BMC Clinical Pathology, Vol 17, Iss 1, Pp 1-10 (2017)
BMC Clinical Pathology
Latif, A, Chadwick, A L, Kitson, S J, Gregson, H J, Sivalingam, V N, Bolton, J, McVey, R J, Roberts, S A, Marshall, K M, Williams, K J, Stratford, I J & Crosbie, E J 2017, ' Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer ', BMC Clinical Pathology, vol. 17, pp. 27 . https://doi.org/10.1186/s12907-017-0067-7
BMC Clinical Pathology
Latif, A, Chadwick, A L, Kitson, S J, Gregson, H J, Sivalingam, V N, Bolton, J, McVey, R J, Roberts, S A, Marshall, K M, Williams, K J, Stratford, I J & Crosbie, E J 2017, ' Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer ', BMC Clinical Pathology, vol. 17, pp. 27 . https://doi.org/10.1186/s12907-017-0067-7
Background Endometrial cancer (EC) is a major health concern due to its rising incidence. Whilst early stage disease is generally cured by surgery, advanced EC has a poor prognosis with limited treatment options. Altered energy metabolism is a hallma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2988b7c7ec7d61abc52b001e69a8d9ac
http://link.springer.com/article/10.1186/s12907-017-0067-7
http://link.springer.com/article/10.1186/s12907-017-0067-7
Autor:
Emma J Crosbie, Sarah Kitson
Publikováno v:
Kitson, S J & Crosbie, E J 2019, ' Endometrial cancer and obesity ', The Obstetrician and Gynaecologist . https://doi.org/10.1111/tog.12601
Key contentOf the 20 most common tumour types, endometrial cancer has the strongest association with obesity.Endometrial cancer should be considered in young, obese women with irregular or heavy menstrual bleeding.To reduce the risk of postoperative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca41062b690c82d9bbe69a389ed6e366
Wiley Online Library
Wiley Online Library
Publikováno v:
Kitson, S, Rosser, M, Fischer, D, Marshall, K, Clarke, R B & Crosbie, E 2019, ' Targeting Endometrial Cancer Stem Cell Activity with Metformin Is Inhibited by Patient-Derived Adipocyte-Secreted Factors ', Cancers . https://doi.org/10.3390/cancers11050653
Cancers, Vol 11, Iss 5, p 653 (2019)
Cancers
Volume 11
Issue 5
Cancers, Vol 11, Iss 5, p 653 (2019)
Cancers
Volume 11
Issue 5
Advanced endometrial cancer continues to have a poor prognosis, due to limited treatment options, which may be further adversely impacted by obesity. Endometrial cancer stem cells have been reported to drive metastasis, chemotherapy resistance and di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec43cacd5feaf635421e9cdffefe8c2e
Autor:
Abigail E Derbyshire, Kelechi Njoku, Anthony D. Whetton, Alan Campbell, Michelle L MacKintosh, Emma J Crosbie, Sarah Kitson, Andrew Pierce, Bethany Geary, Vanitha N Sivalingam
Publikováno v:
Cancers, Vol 13, Iss 718, p 718 (2021)
Cancers
Volume 13
Issue 4
Cancers
Volume 13
Issue 4
Endometrial cancer is the most common malignancy of the female genital tract and a major cause of morbidity and mortality in women. Early detection is key to ensuring good outcomes but a lack of minimally invasive screening tools is a significant bar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ada23d846cfbf92b996c545ac53fe1
https://doi.org/10.3390/cancers13040718
https://doi.org/10.3390/cancers13040718
Autor:
Philip W. Pemberton, Kyle Gilmour, Emma J Crosbie, Henry C Kitchener, Andrew G Renehan, Sarah Kitson, Chris Roberts, Rhona J McVey, Vanitha N Sivalingam, S Ali
Publikováno v:
British Journal of Cancer
Sivalingam, V N, Kitson, S, McVey, R, Roberts, C, Pemberton, P, Gilmour, K, Ali, S, Renehan, A G, Kitchener, H C & Crosbie, E J 2016, ' Measuring the biological effect of presurgical metformin treatment in endometrial cancer ', British Journal of Cancer, vol. 114, no. 3, pp. 281-289 . https://doi.org/10.1038/bjc.2015.453
Sivalingam, V N, Kitson, S, McVey, R, Roberts, C, Pemberton, P, Gilmour, K, Ali, S, Renehan, A G, Kitchener, H C & Crosbie, E J 2016, ' Measuring the biological effect of presurgical metformin treatment in endometrial cancer ', British Journal of Cancer, vol. 114, no. 3, pp. 281-289 . https://doi.org/10.1038/bjc.2015.453
BACKGROUND: Preclinical studies in endometrial cancer (EC) show that metformin reduces cellular proliferation by PI3K-AKT-mTOR inhibition. We tested the hypothesis that short-term presurgical metformin reduces cellular proliferation in atypical endom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4c882dbe65382a4cb633885859ad02
https://doi.org/10.1038/bjc.2015.453
https://doi.org/10.1038/bjc.2015.453
Autor:
Sarah Kitson, Andrew J Wallace, Simon Tobi, Rhona J McVey, Ian M. Frayling, Neil A J Ryan, D. Gareth Evans, Vanitha N Sivalingam, Sancha Bunstone, Naomi L. Bowers, James Bolton, Neal C Ramchander, Ioana E Mosneag, Tristan Snowsill, Emma J Crosbie, Raymond Mcmahon, Helena O'Flynn, Shona Esquibel
Publikováno v:
PLoS Medicine, Vol 17, Iss 9, p e1003263 (2020)
Ryan, N A J, Dawson, L (ed.), McMahon, R, Tobi, S, Snowsill, T, Esquibel, S, Wallace, A J, Bunstone, S, Bowers, N, Mosneag, I E, Kitson, S J, O’Flynn, H, Ramchander, N C, Sivalingam, V N, Frayling, I M, Bolton, J, McVey, R J, Evans, D G & Crosbie, E J 2020, ' The Proportion of Endometrial Tumours Associated with Lynch Syndrome (PETALS): a prospective cross-sectional study ', PL o S Medicine . https://doi.org/10.1371/journal.pmed.1003263, https://doi.org/10.1371/journal.pmed.1003263
Ryan, N A J, McMahon, R, Tobi, S, Snowsill, T, Esquibel, S, Wallace, A J, Bunstone, S, Bowers, N, Mosneag, I E, Kitson, S J, O'Flynn, H, Ramchander, N C, Sivalingam, V N, Frayling, I M, Bolton, J, McVey, R J, Evans, D G & Crosbie, E J 2020, ' The proportion of endometrial tumours associated with Lynch syndrome (PETALS) : A prospective cross-sectional study ', PLoS Medicine, vol. 17, no. 9, pp. e1003263 . https://doi.org/10.1371/journal.pmed.1003263
PLoS Medicine
Ryan, N A J, Dawson, L (ed.), McMahon, R, Tobi, S, Snowsill, T, Esquibel, S, Wallace, A J, Bunstone, S, Bowers, N, Mosneag, I E, Kitson, S J, O’Flynn, H, Ramchander, N C, Sivalingam, V N, Frayling, I M, Bolton, J, McVey, R J, Evans, D G & Crosbie, E J 2020, ' The Proportion of Endometrial Tumours Associated with Lynch Syndrome (PETALS): a prospective cross-sectional study ', PL o S Medicine . https://doi.org/10.1371/journal.pmed.1003263, https://doi.org/10.1371/journal.pmed.1003263
Ryan, N A J, McMahon, R, Tobi, S, Snowsill, T, Esquibel, S, Wallace, A J, Bunstone, S, Bowers, N, Mosneag, I E, Kitson, S J, O'Flynn, H, Ramchander, N C, Sivalingam, V N, Frayling, I M, Bolton, J, McVey, R J, Evans, D G & Crosbie, E J 2020, ' The proportion of endometrial tumours associated with Lynch syndrome (PETALS) : A prospective cross-sectional study ', PLoS Medicine, vol. 17, no. 9, pp. e1003263 . https://doi.org/10.1371/journal.pmed.1003263
PLoS Medicine
Background Lynch syndrome (LS) predisposes to endometrial cancer (EC), colorectal cancer, and other cancers through inherited pathogenic variants affecting mismatch-repair (MMR) genes. Diagnosing LS in women with EC can reduce subsequent cancer morta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b384f46817b9b9b8f00d6e3e59ec6337
https://doi.org/10.1371/journal.pmed.1003263
https://doi.org/10.1371/journal.pmed.1003263