Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Sarah, Kettlewell"'
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Introduction: The development of improved diagnosis, management, and treatment strategies for human atrial fibrillation (AF) is a significant and important challenge in order to improve quality of life for millions and reduce the substantial social-e
Externí odkaz:
https://doaj.org/article/3ecd27f3040e4070802dbd574f442478
Autor:
Godfrey L. Smith, Sarah Kettlewell, Priyanka Saxena, Antony J. Workman, John Dempster, Michael A. Colman, Rachel C. Myles
Publikováno v:
The Journal of Physiology. 597:3619-3638
KEY POINTS Early-afterdepolarizations (EADs) are abnormal action potential oscillations and a known cause of cardiac arrhythmias. Ventricular EADs involve reactivation of a Ca2+ current (ICaL ) in its 'window region' voltage range. However, electrica
Autor:
Erik Sveberg Dietrichs, Karen McGlynn, Rachel C. Myles, Andrew Allan, Sarah Kettlewell, Godfrey L. Smith, Martin J. Bishop, Adam Connolly, Torkjel Tveita, Francis L. Burton
Aims Treatment of arrhythmias evoked by hypothermia/rewarming remains challenging, and the underlying mechanisms are unclear. This in vitro experimental study assessed cardiac electrophysiology in isolated rabbit hearts at temperatures occurring in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7df3bf27835c3141b3c245108a6cce
https://hdl.handle.net/10037/18292
https://hdl.handle.net/10037/18292
Autor:
Sarah, Kettlewell, Priyanka, Saxena, John, Dempster, Michael A, Colman, Rachel C, Myles, Godfrey L, Smith, Antony J, Workman
Publikováno v:
The Journal of Physiology
Key points Early‐afterdepolarizations (EADs) are abnormal action potential oscillations and a known cause of cardiac arrhythmias. Ventricular EADs involve reactivation of a Ca2+ current (I CaL) in its ‘window region’ voltage range. However, ele
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Introduction: The development of improved diagnosis, management and treatment strategies for human atrial fibrillation (AF) is a significant and important challenge in order to improve quality of life for millions and reduce the substantial social-ec
Autor:
Sawsan Awad, Felix Hohendanner, Sarah Kettlewell, Lothar A. Blatter, Vassyl A. Lonchyna, Stefanie Walther, Joshua T. Maxwell, Godfrey L. Smith
Publikováno v:
The Journal of Physiology. 593:1459-1477
Key points Impaired calcium (Ca2+) signalling is the main contributor to depressed ventricular contractile function and occurrence of arrhythmia in heart failure (HF). Here we report that in atrial cells of a rabbit HF model, Ca2+ signalling is enhan
Publikováno v:
Cell Calcium. 56:133-146
I(Ca)-gated Ca(2+) release (CICR) from the cardiac SR is the main mechanism mediating the rise of cytosolic Ca(2+), but the extent to which mitochondria contribute to the overall Ca(2+) signaling remains controversial. To examine the possible role of
Autor:
Anna Raffaello, Jyotsna Mishra, Wang Wang, Godfrey L. Smith, Xiaoyun Liu, Stephen Hurst, Shangcheng Xu, Polina Gross, Shey-Shing Sheu, Rosario Rizzuto, Jin O-Uchi, Huiliang Zhang, Alina Ainbinder, Bing Yi, Bong Sook Jhun, Robert T. Dirksen, Sarah Kettlewell
Publikováno v:
Antioxidants & Redox Signaling. 21:863-879
Aims: Mitochondrial Ca2+ homeostasis is crucial for balancing cell survival and death. The recent discovery of the molecular identity of the mitochondrial Ca2+ uniporter pore (MCU) opens new possibilities for applying genetic approaches to study mito
Autor:
W. J. Lederer, Godfrey L. Smith, Sarah Kettlewell, George S.B. Williams, Aristide C. Chikando
Publikováno v:
Journal of Molecular and Cellular Cardiology
The importance of [Ca2+] in the mitochondrial matrix, [Ca2+]mito, had been proposed by early work of Carafoli and others [1], [2] and [3]. The key suggestion in the 1970s [4] was that regulatory [Ca2+]mito played a role in controlling the rate of act
Autor:
Sarah Kettlewell, Godfrey L. Smith, Pablo Cabrero, Shireen A. Davies, Stuart A. Nicklin, Julian A. T. Dow
Publikováno v:
Journal of Molecular and Cellular Cardiology. 46:891-901
In this study a Ca(2+) sensitive protein was targeted to the mitochondria of adult rabbit ventricular cardiomyocytes using an adenovirus transfection technique. The probe (Mitycam) was a Ca(2+)-sensitive inverse pericam fused to subunit VIII of human