Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Sarah, Hrebien"'
Autor:
Belinda Kingston, Rosalind J. Cutts, Hannah Bye, Matthew Beaney, Giselle Walsh-Crestani, Sarah Hrebien, Claire Swift, Lucy S. Kilburn, Sarah Kernaghan, Laura Moretti, Katie Wilkinson, Andrew M. Wardley, Iain R. Macpherson, Richard D. Baird, Rebecca Roylance, Jorge S. Reis-Filho, Michael Hubank, Iris Faull, Kimberly C. Banks, Richard B. Lanman, Isaac Garcia-Murillas, Judith M. Bliss, Alistair Ring, Nicholas C. Turner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Circulating tumour DNA can provide useful information on disease burden. Here, the authors analysed circulating tumour DNA from 800 patients from a breast cancer clinical trial and investigate the subclonal nature of the disease, and identify DNA mut
Externí odkaz:
https://doaj.org/article/5f176e5d5bcb4792adb4ec1effb35966
Autor:
Ben O’Leary, Sarah Hrebien, James P. Morden, Matthew Beaney, Charlotte Fribbens, Xin Huang, Yuan Liu, Cynthia Huang Bartlett, Maria Koehler, Massimo Cristofanilli, Isaac Garcia-Murillas, Judith M. Bliss, Nicholas C. Turner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Circulating tumor DNA (ctDNA) may provide a prediction of treatment response, but could be impacted by tumor heterogeneity. Here, the authors investigate ctDNA in CDK4/6 inhibitor treatment in advanced breast cancer, finding ctDNA levels predict prog
Externí odkaz:
https://doaj.org/article/fe55104b6a3946c08222bef99156c284
Autor:
Belinda Kingston, Rosalind J. Cutts, Hannah Bye, Matthew Beaney, Giselle Walsh-Crestani, Sarah Hrebien, Claire Swift, Lucy S. Kilburn, Sarah Kernaghan, Laura Moretti, Katie Wilkinson, Andrew M. Wardley, Iain R. Macpherson, Richard D. Baird, Rebecca Roylance, Jorge S. Reis-Filho, Michael Hubank, Iris Faull, Kimberly C. Banks, Richard B. Lanman, Isaac Garcia-Murillas, Judith M. Bliss, Alistair Ring, Nicholas C. Turner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/c4a8fb81f49749e99d11db28fb611c64
Autor:
Nicholas C. Turner, Juanita S. Lopez, Timothy A. Yap, Emma Hall, Alison Turner, Florence I. Raynaud, Ruth Ruddle, Karen E. Swales, Jason Malia, Laura Finneran, Toby Prout, Mona Parmar, Jenny King, Margaret Hills, Michael Hubank, Paula Z. Proszek, Heidrun Gevensleben, Sarah Hrebien, Alex Pearson, Isaac Garcia-Murillas, Maria Teresa Herrera-Abreu, Rosalind J. Cutts, Alicia F.C. Okines, Alistair Ring, Anne C. Armstrong, Iain R. Macpherson, Joline S.J. Lim, Javier Pascual
Escalation phase dose levels and final recruitment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbcf33f6c433c0a43b2c0b533ff6f99
https://doi.org/10.1158/2159-8290.22535459.v1
https://doi.org/10.1158/2159-8290.22535459.v1
Autor:
Nicholas C. Turner, Cynthia Huang Bartlett, Massimo Cristofanilli, Isaac Garcia-Murillas, Sherene Loi, Sibylle Loibl, Fabrice André, Kerry Fenwick, Xin Huang, Sarah Hrebien, Yuan Liu, Rosalind J. Cutts, Ben O'Leary
Supplementary figures and tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c79b10deff81ae4714c12ad69bc9c87
https://doi.org/10.1158/2159-8290.22531976.v1
https://doi.org/10.1158/2159-8290.22531976.v1
Autor:
Nicholas C. Turner, Juanita S. Lopez, Timothy A. Yap, Emma Hall, Alison Turner, Florence I. Raynaud, Ruth Ruddle, Karen E. Swales, Jason Malia, Laura Finneran, Toby Prout, Mona Parmar, Jenny King, Margaret Hills, Michael Hubank, Paula Z. Proszek, Heidrun Gevensleben, Sarah Hrebien, Alex Pearson, Isaac Garcia-Murillas, Maria Teresa Herrera-Abreu, Rosalind J. Cutts, Alicia F.C. Okines, Alistair Ring, Anne C. Armstrong, Iain R. Macpherson, Joline S.J. Lim, Javier Pascual
RMH200 panel design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463cc86a1d265fa62da6f6887c6a661c
https://doi.org/10.1158/2159-8290.22535438.v1
https://doi.org/10.1158/2159-8290.22535438.v1
Autor:
Nicholas C. Turner, Juanita S. Lopez, Timothy A. Yap, Emma Hall, Alison Turner, Florence I. Raynaud, Ruth Ruddle, Karen E. Swales, Jason Malia, Laura Finneran, Toby Prout, Mona Parmar, Jenny King, Margaret Hills, Michael Hubank, Paula Z. Proszek, Heidrun Gevensleben, Sarah Hrebien, Alex Pearson, Isaac Garcia-Murillas, Maria Teresa Herrera-Abreu, Rosalind J. Cutts, Alicia F.C. Okines, Alistair Ring, Anne C. Armstrong, Iain R. Macpherson, Joline S.J. Lim, Javier Pascual
Cyclin-dependent kinase 4/6 (CDK4/6) and PI3K inhibitors synergize in PIK3CA-mutant ER-positive HER2-negative breast cancer models. We conducted a phase Ib trial investigating the safety and efficacy of doublet CDK4/6 inhibitor palbociclib plus selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2188840c665bdd2ddabfa9e80f44d33
https://doi.org/10.1158/2159-8290.c.6547859.v1
https://doi.org/10.1158/2159-8290.c.6547859.v1
Supplementary Figure 8 from The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer
Autor:
Andrea Sottoriva, Nicholas Turner, Gaia Schiavon, Yinyin Yuan, Rachael Natrajan, Carlo C. Maley, Mitch Dowsett, Francesca Muscara, Jennifer E. Rusby, Saira Khalique, Konrad Koelble, Lila Zabaglo, Hannah Cottom, Ian Said Huntingford, Luca Ermini, Kate Chkhaidze, Isaac Garcia-Murillas, Sarah Hrebien, Nicholas Trahearn, Ahmet Acar, George D. Cresswell, Daniel Nichol, Inmaculada Spiteri, Alexandra Vatsiou, Peter Barry
Figure S8. CCF comparisons between multiple tumour samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e14909e7526f88855b2f85c54402048
https://doi.org/10.1158/1078-0432.22470770.v1
https://doi.org/10.1158/1078-0432.22470770.v1
Autor:
Andrea Sottoriva, Nicholas Turner, Gaia Schiavon, Yinyin Yuan, Rachael Natrajan, Carlo C. Maley, Mitch Dowsett, Francesca Muscara, Jennifer E. Rusby, Saira Khalique, Konrad Koelble, Lila Zabaglo, Hannah Cottom, Ian Said Huntingford, Luca Ermini, Kate Chkhaidze, Isaac Garcia-Murillas, Sarah Hrebien, Nicholas Trahearn, Ahmet Acar, George D. Cresswell, Daniel Nichol, Inmaculada Spiteri, Alexandra Vatsiou, Peter Barry
Whole-exome sequencing mutations cancer cell fractions used in Figure S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab9de59a4fd3a9d387ffb9f298eb3e2
https://doi.org/10.1158/1078-0432.22470746
https://doi.org/10.1158/1078-0432.22470746
Autor:
Andrea Sottoriva, Nicholas Turner, Gaia Schiavon, Yinyin Yuan, Rachael Natrajan, Carlo C. Maley, Mitch Dowsett, Francesca Muscara, Jennifer E. Rusby, Saira Khalique, Konrad Koelble, Lila Zabaglo, Hannah Cottom, Ian Said Huntingford, Luca Ermini, Kate Chkhaidze, Isaac Garcia-Murillas, Sarah Hrebien, Nicholas Trahearn, Ahmet Acar, George D. Cresswell, Daniel Nichol, Inmaculada Spiteri, Alexandra Vatsiou, Peter Barry
Copy number alterations calls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043ce1557a5b6e269bec3a36b997e18f
https://doi.org/10.1158/1078-0432.22470776.v1
https://doi.org/10.1158/1078-0432.22470776.v1