Výsledky vyhledávání - "Sarah, Hostachy"

Akademický článek

Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction

Autor: Joka Pipercevic, Bastian Kohl, Ruta Gerasimaite, Véronique Comte-Miserez, Sarah Hostachy, Thomas Müntener, Elia Agustoni, Henning Jacob Jessen, Dorothea Fiedler, Andreas Mayer, Sebastian Hiller

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract Many proteins involved in eukaryotic phosphate homeostasis are regulated by SPX domains. In yeast, the vacuolar transporter chaperone (VTC) complex contains two such domains, but mechanistic details of its regulation are not well understood.

Externí odkaz: https://doaj.org/article/82eac77b93e04c1ca18805d095b77af8

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Akademický článek

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

Autor: Tim Aguirre, Gillian L Dornan, Sarah Hostachy, Martin Neuenschwander, Carola Seyffarth, Volker Haucke, Anja Schütz, Jens Peter von Kries, Dorothea Fiedler

Publikováno v: eLife, Vol 12 (2023)

Inositol hexakisphosphate kinases (IP6Ks) are emerging as relevant pharmacological targets because a multitude of disease-related phenotypes has been associated with their function. While the development of potent IP6K inhibitors is gaining momentum,

Externí odkaz: https://doaj.org/article/a75de456d60044e1a66071232f84b136

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A Series of Ni Complexes Based on a Versatile ATCUN-Like Tripeptide Scaffold to Decipher Key Parameters for Superoxide Dismutase Activity

Autor: Jérémy Domergue, Pawel Guinard, Magali Douillard, Jacques Pécaut, Sarah Hostachy, Olivier Proux, Colette Lebrun, Alan Le Goff, Pascale Maldivi, Carole Duboc, Pascale Delangle

Publikováno v: Inorganic Chemistry.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f28e2c15f62afdb0e75f90cb3c73022
https://doi.org/10.1021/acs.inorgchem.3c00766

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Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs†

Autor: Volker Haucke, Berke Türkaydin, Tillmann Utesch, Katy Franke, Sarah Hostachy, Gillian L. Dornan, Dorothea Fiedler, David Furkert, Han Sun

Publikováno v: Chemical Science

Inositol poly- and pyrophosphates (InsPs and PP-InsPs) are densely phosphorylated eukaryotic messengers, which are involved in numerous cellular processes. To elucidate their signaling functions at the molecular level, non-hydrolyzable bisphosphonate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea16f3788ec9c2df34832b0e8b79b7b5
http://europepmc.org/articles/PMC8372538

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A Simple Fluorescence Affinity Assay to Decipher Uranyl-Binding to Native Proteins

Autor: Fanny Laporte, Yves Chenavier, Alexandra Botz, Christelle Gateau, Colette Lebrun, Sarah Hostachy, Claude Vidaud, Pascale Delangle

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2022, 61 (26), ⟨10.1002/anie.202203198⟩

Determining the affinity of proteins for uranyl is key to understand the toxicity of this cation and to further develop decorporation strategies. However, usual techniques to achieve that goal often require specific equipment and expertise. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a581505611dcfcacc59daa662acdff69
https://pubmed.ncbi.nlm.nih.gov/35466512

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InsP 7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics

Autor: Soumyadip Sahu, Dorothea Fiedler, Stephen B. Shears, Chunfang Gu, Nikolaus Jork, Megerditch Kiledjian, Sarah Hostachy, Christopher Wittwer, Henning J. Jessen, Xingyao Li, Huanchen Wang, Zhenzhen Wang, Xinfu Jiao

Publikováno v: Proceedings of the National Academy of Sciences. 117:19245-19253

Regulation of enzymatic 5' decapping of messenger RNA (mRNA), which normally commits transcripts to their destruction, has the capacity to dynamically reshape the transcriptome. For example, protection from 5' decapping promotes accumulation of mRNAs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecac6325086313d5f731764ae2277792
https://doi.org/10.1073/pnas.1922284117

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Control of XPR1-dependent cellular phosphate efflux by InsP 8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling

Autor: Dorothea Fiedler, Stephen B. Shears, Chunfang Gu, Xingyao Li, Huanchen Wang, Henning J. Jessen, Soumyadip Sahu, Christopher Wittwer, Sarah Hostachy

Publikováno v: Proc Natl Acad Sci U S A

Homeostasis of cellular fluxes of inorganic phosphate (Pi) supervises its structural roles in bones and teeth, its pervasive regulation of cellular metabolism, and its functionalization of numerous organic compounds. Cellular Pi efflux is heavily rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fccb473eb5fe1bbdff8864ccd11398
https://doi.org/10.1073/pnas.1908830117

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New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1

Autor: Stephen B. Shears, Huanchen Wang, Henning J. Jessen, Dorothea Fiedler, Guangning Zong, Nikolaus Jork, Sarah Hostachy

Publikováno v: FASEB J
BASE-Bielefeld Academic Search Engine

Nudix hydrolases attract considerable attention for their wide range of specialized activities in all domains of life. One particular group of Nudix phosphohydrolases (DIPPs), through their metabolism of diphosphoinositol polyphosphates (PP-InsPs), r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8116013a4462378a78c181af37c480d
https://doi.org/10.1096/fj.202001489r

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InsP

Autor: Soumyadip, Sahu, Zhenzhen, Wang, Xinfu, Jiao, Chunfang, Gu, Nikolaus, Jork, Christopher, Wittwer, Xingyao, Li, Sarah, Hostachy, Dorothea, Fiedler, Huanchen, Wang, Henning J, Jessen, Megerditch, Kiledjian, Stephen B, Shears

Publikováno v: Proc Natl Acad Sci U S A

Regulation of enzymatic 5′ decapping of messenger RNA (mRNA), which normally commits transcripts to their destruction, has the capacity to dynamically reshape the transcriptome. For example, protection from 5′ decapping promotes accumulation of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::63e6f0b9eb8beb4206f48fa1c0b9ed1f
https://pubmed.ncbi.nlm.nih.gov/32727897

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Monitoring bicosomes containing antioxidants in normal and irradiated skin

Autor: Alfonso de la Maza, Mercedes Cócera, Clotilde Policar, Sarah Hostachy, Estibalitz Fernández, Sylvain Clède, Christophe Sandt, Hélène Bertrand, Gelen Rodríguez, François Lambert, Olga López

Publikováno v: RSC Advances
RSC Advances, 2016, 6 (76), pp.72559-72567. ⟨10.1039/C6RA11170J⟩
RSC Advances, Royal Society of Chemistry, 2016, 6 (76), pp.72559-72567. ⟨10.1039/C6RA11170J⟩

This study evaluates the penetration of bicosome systems incorporating two different antioxidants into normal skin and skin exposed to ultraviolet-visible radiation (UV-VIS) by Fourier-transform infrared microspectroscopy (FT-IR) using synchrotron ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3dbb52db249d2ca4fc598b8f224b48d
https://doi.org/10.1039/c6ra11170j

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