Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sarah, Gierke"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IL-15 has shown preclinical activity by enhancing the functional maturation of natural killer (NK) cells. Clinical evaluation of the potential anticancer activity of most cytokines, including IL-15, has been limited by low tolerability and rapid in v
Externí odkaz:
https://doaj.org/article/5406c8a14eed45c8bcc290797e11c107
Autor:
Lucia Taraborrelli, Yasin Şenbabaoğlu, Lifen Wang, Junghyun Lim, Kerrigan Blake, Noelyn Kljavin, Sarah Gierke, Alexis Scherl, James Ziai, Erin McNamara, Mark Owyong, Shilpa Rao, Aslihan Karabacak Calviello, Daniel Oreper, Suchit Jhunjhunwala, Guillem Argiles, Johanna Bendell, Tae Won Kim, Fortunato Ciardiello, Matthew J. Wongchenko, Frederic J. de Sauvage, Felipe de Sousa e Melo, Yibing Yan, Nathaniel R. West, Aditya Murthy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Microsatellite-stable colorectal cancer (MSS-CRC) is highly refractory to immunotherapy. Understanding tumor-intrinsic determinants of immunotherapy resistance is critical to improve MSS-CRC patient outcomes. Here, we demonstrate that high t
Externí odkaz:
https://doaj.org/article/60a294e8ef9e4b37a641c0c3e8919afe
Autor:
Arivazhagan Sambandam, Elaine Storm, Helen Tauc, Jason A. Hackney, David Garfield, Patrick Caplazi, John Liu, Juan Zhang, Hua Zhang, Jeff Duggan, Surinder Jeet, Sarah Gierke, Patrick Chang, Xiumin Wu, Robert Newman, Lucinda Tam, Tuija Alcantar, Lifen Wang, Meron Roose-Girma, Zora Modrusan, Wyne P. Lee, Heinrich Jasper, Frederic de Sauvage, Rajita Pappu
Publikováno v:
Heliyon, Vol 9, Iss 3, Pp e14238- (2023)
The ability of stem cells to rapidly proliferate and differentiate is integral to the steady-state maintenance of tissues with high turnover such as the blood and intestine. Mutations that alter these processes can cause primary immunodeficiencies, m
Externí odkaz:
https://doaj.org/article/5f0b411f56a24ccdae5dfc7e215eea4e
Autor:
Jillian L. Astarita, Shilpa Keerthivasan, Bushra Husain, Yasin Şenbabaoğlu, Erik Verschueren, Sarah Gierke, Victoria C. Pham, Sean M. Peterson, Cecile Chalouni, Andrew A. Pierce, Jennie R. Lill, Lino C. Gonzalez, Nadia Martinez-Martin, Shannon J. Turley
Publikováno v:
PLoS ONE, Vol 16, Iss 12 (2021)
The cancer-associated fibroblast (CAF) marker podoplanin (PDPN) is generally correlated with poor clinical outcomes in cancer patients and thus represents a promising therapeutic target. Despite its biomedical relevance, basic aspects of PDPN biology
Externí odkaz:
https://doaj.org/article/87b716521ce444d8bffa72f85fd9fcc7
Autor:
Mona Abed, Erik Verschueren, Hanna Budayeva, Peter Liu, Donald S Kirkpatrick, Rohit Reja, Sarah K Kummerfeld, Joshua D Webster, Sarah Gierke, Mike Reichelt, Keith R Anderson, Robert J Newman, Merone Roose-Girma, Zora Modrusan, Hazal Pektas, Emin Maltepe, Kim Newton, Vishva M Dixit
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214110 (2019)
Peg10 (paternally expressed gene 10) is an imprinted gene that is essential for placental development. It is thought to derive from a Ty3-gyspy LTR (long terminal repeat) retrotransposon and retains Gag and Pol-like domains. Here we show that the Gag
Externí odkaz:
https://doaj.org/article/93959bf6c69541c08084758f11b3be34
Autor:
Shannon J. Turley, Richard Bourgon, Christiaan Klijn, Melissa R. Junttila, Yuxin Liang, Zora Modrusan, Yasin Senbabaoglu, Alessandra Castiglioni, Travis W. Bainbridge, Oded Foreman, Beatrice Breart, Sarah Gierke, Jeffrey Hung, Hartmut Koeppen, Shilpa Keerthivasan, Sören Müller, Claudia X. Dominguez
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17036d99dfac5b425f100bf442bc4078
https://doi.org/10.1158/2159-8290.22535605
https://doi.org/10.1158/2159-8290.22535605
Autor:
Shannon J. Turley, Richard Bourgon, Christiaan Klijn, Melissa R. Junttila, Yuxin Liang, Zora Modrusan, Yasin Senbabaoglu, Alessandra Castiglioni, Travis W. Bainbridge, Oded Foreman, Beatrice Breart, Sarah Gierke, Jeffrey Hung, Hartmut Koeppen, Shilpa Keerthivasan, Sören Müller, Claudia X. Dominguez
With only a fraction of patients responding to cancer immunotherapy, a better understanding of the entire tumor microenvironment is needed. Using single-cell transcriptomics, we chart the fibroblastic landscape during pancreatic ductal adenocarcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21760ad50b8a606ffa25c5c4c72872ba
https://doi.org/10.1158/2159-8290.c.6547891.v1
https://doi.org/10.1158/2159-8290.c.6547891.v1
Autor:
Hsiao-Yen Ma, Jason A. Vander Heiden, Salil Uttarwar, Ying Xi, Elsa-Noah N'Diaye, Ryan LaCanna, Patrick Caplazi, Sarah Gierke, John Moffat, Paul J. Wolters, Ning Ding
Publikováno v:
The European respiratory journal.
BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease characterised by aberrant fibroblast/myofibroblast accumulation and excessive collagen matrix deposition in the alveolar areas of lungs. As the first approved IPF medicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d46e3b2a33118a861e85285f75ffd8
https://pubmed.ncbi.nlm.nih.gov/36585256
https://pubmed.ncbi.nlm.nih.gov/36585256
Autor:
Melissa R. Junttila, Oded Foreman, Sören Müller, Béatrice Breart, Yuxin Liang, Yasin Senbabaoglu, Christiaan Klijn, Richard Bourgon, Claudia X. Dominguez, Jeffrey Hung, Shilpa Keerthivasan, Travis W. Bainbridge, Zora Modrusan, Hartmut Koeppen, Shannon J. Turley, Alessandra Castiglioni, Sarah Gierke
Publikováno v:
Cancer Discovery. 10:232-253
With only a fraction of patients responding to cancer immunotherapy, a better understanding of the entire tumor microenvironment is needed. Using single-cell transcriptomics, we chart the fibroblastic landscape during pancreatic ductal adenocarcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b94efb3b9e35dd3ff7f5536128f7e39f
https://doi.org/10.1158/2159-8290.cd-19-0644
https://doi.org/10.1158/2159-8290.cd-19-0644
Autor:
Sarah E. Headland, Hart S. Dengler, Daqi Xu, Grace Teng, Christine Everett, Rojo A. Ratsimandresy, Donghong Yan, Jing Kang, Kirthana Ganeshan, Evgeniya V. Nazarova, Sarah Gierke, Christopher J. Wedeles, Riccardo Guidi, Daryle J. DePianto, Katrina B. Morshead, Alison Huynh, Jessica Mills, Sean Flanagan, Shannon Hambro, Victor Nunez, Joanna E. Klementowicz, Yongchang Shi, Jianyong Wang, Jack Bevers, Vladimir Ramirez-Carrozzi, Rajita Pappu, Alex Abbas, Jason Vander Heiden, David F. Choy, Rajbharan Yadav, Zora Modrusan, Reynold A. Panettieri, Cynthia Koziol-White, William F. Jester, Brendan J. Jenkins, Yi Cao, Christine Clarke, Cary Austin, Daniel Lafkas, Min Xu, Paul J. Wolters, Joseph R. Arron, Nathaniel R. West, Mark S. Wilson
Publikováno v:
Science translational medicine. 14(627)
Exacerbations of symptoms represent an unmet need for people with asthma. Bacterial dysbiosis and opportunistic bacterial infections have been observed in, and may contribute to, more severe asthma. However, the molecular mechanisms driving these exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46323ac4e1c7c49de3c9a3a4fd365072
https://pubmed.ncbi.nlm.nih.gov/35110748
https://pubmed.ncbi.nlm.nih.gov/35110748