Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sarah, Frew"'
Autor:
Benjamin N. Atkinson, Nicky J. Willis, Yuguang Zhao, Chandni Patel, Sarah Frew, Kathryn Costelloe, Lorenza Magno, Fredrik Svensson, E. Yvonne Jones, Paul V. Fish
Publikováno v:
European Journal of Medicinal Chemistry. 251:115132
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c67f2b178d0c6ac790dd98f0ff8ccd64
https://doi.org/10.1016/j.ejmech.2023.115132
https://doi.org/10.1016/j.ejmech.2023.115132
Autor:
Nicky Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah Woodward, Benjamin Atkinson, Elliott Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnu, Sarah Jolly, Luca Vecchia, Reinis Ruza, Svend Kjaer, Steven Howell, Ambrosius Snidjers, Magda Bictash, Patricia Salinas, Jean-Paul Vincent, Yvonne Jones, Paul Whiting, Paul Fish
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human disease such as colorectal cancer and Alzheimer’s di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8addc522ec8ef944de3c1786ccffb9ca
https://doi.org/10.26434/chemrxiv-2022-f05w8
https://doi.org/10.26434/chemrxiv-2022-f05w8
Autor:
Nicky J. Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah L. Woodward, Benjamin N. Atkinson, Elliott D. Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnù, Sarah Jolly, Luca Vecchia, Reinis R. Ruza, Svend Kjær, Steven Howell, Ambrosius P. Snijders, Magda Bictash, Patricia C. Salinas, Jean-Paul Vincent, E. Yvonne Jones, Paul Whiting, Paul V. Fish
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human diseases such as colorectal cancer and Alzheimer's dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3474b8ac04a0b606e41a67edadf62c69
Autor:
David Steadman, Benjamin N. Atkinson, Yuguang Zhao, Nicky J. Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, E. Yvonne Jones, Paul V. Fish, Fredrik Svensson
Publikováno v:
Journal of medicinal chemistry. 65(1)
Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Inhibitors of Notum could be of use in diseases where dysfunctional Notum activity is an underlying cause. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40edd35a69ac0b95580d171b01ebf3b1
https://pubmed.ncbi.nlm.nih.gov/34939789
https://pubmed.ncbi.nlm.nih.gov/34939789
Autor:
William, Mahy, Nicky J, Willis, Yuguang, Zhao, Hannah L, Woodward, Fredrik, Svensson, James, Sipthorp, Luca, Vecchia, Reinis R, Ruza, James, Hillier, Svend, Kjær, Sarah, Frew, Amy, Monaghan, Magda, Bictash, Patricia C, Salinas, Paul, Whiting, Jean-Paul, Vincent, E Yvonne, Jones, Paul V, Fish
Publikováno v:
Journal of medicinal chemistry. 63(21)
Carboxylesterase Notum is a negative regulator of the Wnt signaling pathway. There is an emerging understanding of the role Notum plays in disease, supporting the need to discover new small-molecule inhibitors. A crystallographic X-ray fragment scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07128c1ea3b73521973fe7fd4ebe3825
https://pubmed.ncbi.nlm.nih.gov/33124429
https://pubmed.ncbi.nlm.nih.gov/33124429
Autor:
Benjamin N, Atkinson, David, Steadman, Yuguang, Zhao, James, Sipthorp, Luca, Vecchia, Reinis R, Ruza, Fiona, Jeganathan, Georgie, Lines, Sarah, Frew, Amy, Monaghan, Svend, Kjær, Magda, Bictash, E Yvonne, Jones, Paul V, Fish
Publikováno v:
MedChemComm
Optimization of fragment hit 3 identified isoquinoline 45 as a potent inhibitor of NOTUM with an unexpected flipped binding mode.
NOTUM is a carboxylesterase that has been shown to act by mediating the O-depalmitoleoylation of Wnt proteins resul
NOTUM is a carboxylesterase that has been shown to act by mediating the O-depalmitoleoylation of Wnt proteins resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbb625a59f2dade8bff75e1d10556061
https://pubmed.ncbi.nlm.nih.gov/31534655
https://pubmed.ncbi.nlm.nih.gov/31534655
Autor:
Sarah Frew
Introduction This chapter describes the current state of India's health biotechnology sector and the factors enabling domestic companies to transition into global research and development-(R&D) based innovators. Historically, Indian companies entered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67a2de083f709a47ce179efb7a2992c1
https://doi.org/10.1017/cbo9781107360242.015
https://doi.org/10.1017/cbo9781107360242.015
Autor:
Sarah Frew
Publikováno v:
Physics Bulletin. 36:412-413
One of the main clinical applications of ultrasound is in the measurement of blood flow in the heart and main vessels, and in 'Doppler imaging' of the heart and vessels themselves. Frequencies in the range 3–10 MHz are usually used for these purpos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9428399bb6c2e56dc92802cbb567aa1a
https://doi.org/10.1088/0031-9112/36/10/017
https://doi.org/10.1088/0031-9112/36/10/017