Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Sarah, Derks"'
Autor:
Amber P. van der Zalm, Mark P. G. Dings, Paul Manoukian, Hannah Boersma, Reimer Janssen, Peter Bailey, Jan Koster, Danny Zwijnenburg, Richard Volckmann, Sanne Bootsma, Cynthia Waasdorp, Monique van Mourik, Dionne Blangé, Tom van den Ende, César I. Oyarce, Sarah Derks, Aafke Creemers, Eva A. Ebbing, Gerrit K. Hooijer, Sybren L. Meijer, Mark I. van Berge Henegouwen, Jan Paul Medema, Hanneke W. M. van Laarhoven, Maarten F. Bijlsma
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-11 (2024)
Abstract Background Despite the advent of neoadjuvant chemoradiotherapy (CRT), overall survival rates of esophageal adenocarcinoma (EAC) remain low. A readily induced mesenchymal transition of EAC cells contributes to resistance to CRT. Methods In th
Externí odkaz:
https://doaj.org/article/d7fc9df802d34addb7ab614129c458e9
Autor:
Carolina Martinez-Ciarpaglini, Daniela S Thommen, Nicole C T van Grieken, Joep Grootjans, Sarah Derks, Tessa S Groen-van Schooten, Rosalia Franco Fernandez, Emma N Bos, Jens Seidel, Job Saris, Tania C Fleitas
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background Tertiary lymphoid structures (TLSs) are thought to stimulate antitumor immunity and positively impact prognosis and response to immune checkpoint blockade. In gastric cancers (GCs), however, TLSs are predominantly found in GC with poor pro
Externí odkaz:
https://doaj.org/article/785d4f4c841145b58d42944ccbc30db0
Autor:
Tessa S. Groen-van Schooten, Micaela Harrasser, Jens Seidel, Emma N. Bos, Tania Fleitas, Monique van Mourik, Roos E. Pouw, Ruben S. A. Goedegebuure, Benthe H. Doeve, Jasper Sanders, Joris Bos, Mark I. van Berge Henegouwen, Victor L. J. L. Thijssen, Nicole C. T. van Grieken, Hanneke W. M. van Laarhoven, Tanja D. de Gruijl, Sarah Derks
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundTumors in the distal esophagus (EAC), gastro-esophageal junction including cardia (GEJAC), and stomach (GAC) develop in close proximity and show strong similarities on a molecular and cellular level. However, recent clinical data showed tha
Externí odkaz:
https://doaj.org/article/7290fb7a97854b94b461883d4c42e038
Autor:
Tom van den Ende, Aiarpi Ezdoglian, Lisanne M. Baas, Joyce Bakker, Sinéad M. Lougheed, Micaela Harrasser, Cynthia Waasdorp, Mark I. van Berge Henegouwen, Maarten C.C.M. Hulshof, Nadia Haj Mohammad, Richard van Hillegersberg, Stella Mook, Conny J. van der Laken, Nicole C.T. van Grieken, Sarah Derks, Maarten F. Bijlsma, Hanneke W.M. van Laarhoven, Tanja D. de Gruijl
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTThe analysis of peripheral blood mononuclear cells (PBMCs) by flow cytometry holds promise as a platform for immune checkpoint inhibition (ICI) biomarker identification. Our aim was to characterize the systemic immune compartment in resectabl
Externí odkaz:
https://doaj.org/article/875b94688d2a4d92a00af551e8bbb88a
Autor:
Tessa Suzanne van Schooten, Sarah Derks, Elena Jiménez-Martí, Fatima Carneiro, Ceu Figueiredo, Erika Ruiz, Maria Alsina, Cristina Molero, Marcelo Garrido, Arnoldo Riquelme, Carmelo Caballero, Eva Lezcano, Juan Manuel O’Connor, Federico Esteso, Judith Farrés, José Manuel Mas, Florian Lordick, Jeannette Vogt, Antonella Cardone, Charis Girvalaki, Andrés Cervantes, Tania Fleitas, on behalf of the members of LEGACy consortium
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-8 (2022)
Abstract Background Gastric Cancer (GC) is the fourth most deadly cancer worldwide. Enhanced understanding of its key epidemiological and molecular drivers is urgently needed to lower the incidence and improve outcomes. Furthermore, tumor biology in
Externí odkaz:
https://doaj.org/article/000f8301cb034a3c9478250288367cff
Autor:
Marieke Pape, Pauline A. J. Vissers, Willemieke P. M. Dijksterhuis, David Bertwistle, Laura McDonald, Bianca Mostert, Sarah Derks, Irma M. Oving, Rob H. A. Verhoeven, Hanneke W. M. van Laarhoven
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Background: Treatment of advanced or metastatic esophageal adenocarcinoma (EAC) follows the guidelines for gastroesophageal junction adenocarcinoma (GEJC) and gastric adenocarcinoma (GAC), but patients with EAC are often excluded from clinical studie
Externí odkaz:
https://doaj.org/article/da8a32e3e4c643658b983aa7f4de6aaa
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 14 (2022)
Externí odkaz:
https://doaj.org/article/73f25d4ba9454d4f961a58447e1a5859
Autor:
Ruben S. A. Goedegebuure, Esther A. Kleibeuker, Francesca M. Buffa, Kitty C. M. Castricum, Syed Haider, Iris A. Schulkens, Luuk ten Kroode, Jaap van den Berg, Maarten A. J. M. Jacobs, Anne-Marie van Berkel, Nicole C. T. van Grieken, Sarah Derks, Ben J. Slotman, Henk M. W. Verheul, Adrian L. Harris, Victor L. Thijssen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)
Abstract Background Improvement of radiotherapy efficacy requires better insight in the dynamic responses that occur during irradiation. Here, we aimed to identify the molecular responses that are triggered during clinically applied fractionated irra
Externí odkaz:
https://doaj.org/article/0b5244fd5d7a4fdfa9186fcbf89b155f
Autor:
Leonie K. deKlerk, Ruben S. A. Goedegebuure, Nicole C. T. vanGrieken, Johanna W. vanSandick, Annemieke Cats, Jurrien Stiekema, Rosa T. van derKaaij, Arantza Farina Sarasqueta, Manon vanEngeland, Maarten A. J. M. Jacobs, Roy L. J. vanWanrooij, Donald L. van derPeet, Aaron R. Thorner, Henk M. W. Verheul, Victor L. J. L. Thijssen, Adam J. Bass, Sarah Derks
Publikováno v:
Molecular Oncology, Vol 15, Iss 4, Pp 901-914 (2021)
Identification of molecular predictive markers of response to neoadjuvant chemoradiation could aid clinical decision‐making in patients with localized oesophageal cancer. Therefore, we subjected pretreatment biopsies of 75 adenocarcinoma (OAC) and
Externí odkaz:
https://doaj.org/article/7932eb37d9894db684b21beafaa514b4
Autor:
Charlotte I Stroes, Sandor Schokker, Mohammed Khurshed, Stephanie O van der Woude, Ron AA Mathôt, Marije Slingerland, Judith de Vos-Geelen, Massimo Zucchetti, Cristina Matteo, Erik van Dijk, Bauke Ylstra, Victor Thijssen, Sarah Derks, Tesfay Godefa, Willemieke Dijksterhuis, Gerben E Breimer, Otto M van Delden, Rob HA Verhoeven, Sybren L Meijer, Maarten F Bijlsma, Hanneke WM van Laarhoven
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 14 (2022)
Purpose: Regorafenib monotherapy, a multikinase inhibitor of angiogenesis, tumor microenvironment, and tumorigenesis, showed promising results in gastric cancer. We aimed to assess the tolerability of regorafenib and paclitaxel in patients with advan
Externí odkaz:
https://doaj.org/article/aed72a810b8b46b7a7487a5ebbe32545