Výsledky vyhledávání - "Sarah, Daley"

Akademický článek

Effect of the ROCK inhibitor fasudil on the brain proteomic profile in the tau transgenic mouse model of Alzheimer's disease

Autor: Roberto Collu, Zheng Yin, Elisa Giunti, Sarah Daley, Mei Chen, Peter Morin, Richard Killick, Stephen T. C. Wong, Weiming Xia

Publikováno v: Frontiers in Aging Neuroscience, Vol 16 (2024)

IntroductionThe goal of this study is to explore the pharmacological potential of the amyloid-reducing vasodilator fasudil, a selective Ras homolog (Rho)-associated kinases (ROCK) inhibitor, in the P301S tau transgenic mouse model (Line PS19) of neur

Externí odkaz: https://doaj.org/article/738526ed29cf4602848657bb379d4868

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Akademický článek

A comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease

Publikováno v: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)

Abstract Background Cerebrospinal fluid (CSF) tau and beta-amyloid levels in chronic traumatic encephalopathy (CTE), a disease which can be clinically indistinguishable from Alzheimer’s disease (AD), are largely unknown. We examined postmortem CSF

Externí odkaz: https://doaj.org/article/4f7f418230ce468aace772cfd97ce8e6

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Akademický článek

CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy

Autor: Jonathan D. Cherry, Gaoyuan Meng, Sarah Daley, Weiming Xia, Sarah Svirsky, Victor E. Alvarez, Raymond Nicks, Morgan Pothast, Hunter Kelley, Bertrand Huber, Yorghos Tripodis, Michael L. Alosco, Jesse Mez, Ann C. McKee, Thor D. Stein

Publikováno v: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-12 (2020)

Abstract Background Neuroinflammation has been implicated in the pathogenesis of chronic traumatic encephalopathy (CTE), a progressive neurodegenerative disease association with exposure to repetitive head impacts (RHI) received though playing contac

Externí odkaz: https://doaj.org/article/f86c5fd4709d442c9de2bc0be5e08412

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Akademický článek

Upregulation of Neuroinflammatory Protein Biomarkers in Acute Rhegmatogenous Retinal Detachments

Autor: Minali Prasad, Jia Xu, Joshua S. Agranat, Weiming Xia, Sarah Daley, Steven Ness, Xuejing Chen, Nicole H. Siegel, Thor D. Stein, Jaeyoon Chung, Manju L. Subramanian

Publikováno v: Life, Vol 13, Iss 1, p 118 (2022)

The purpose of this study is to characterize the inflammatory cytokine profile in rhegmatogenous retinal detachments (RRDs) compared to surgical controls. Vitreous humor was collected from patients undergoing vitrectomy for RRD and noninflammatory vi

Externí odkaz: https://doaj.org/article/77893be634b54a26af482fdea2c281f0

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Vascular injury is associated with repetitive head impacts and tau pathology in chronic traumatic encephalopathy

Autor: Daniel, Kirsch, Arsal, Shah, Erin, Dixon, Hunter, Kelley, Jonathan D, Cherry, Weiming, Xia, Sarah, Daley, Nurgul, Aytan, Kerry, Cormier, Carol, Kubilus, Rebecca, Mathias, Victor E, Alvarez, Bertrand R, Huber, Ann C, McKee, Thor D, Stein

Publikováno v: J Neuropathol Exp Neurol

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repetitive head impacts (RHI) and characterized by perivascular hyperphosphorylated tau (p-tau) deposits. The role of vascular injury, blood-brain barrier leakage, and ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290c444d5badd21f272654251befc422
https://doi.org/10.1093/jnen/nlac122

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Role of Lymphatic Deficiency in the Pathogenesis and Progression of Inflammatory Bowel Disease to Colorectal Cancer in an Experimental Mouse Model

Autor: Jennifer Thorn, Nathan Tanoue, M. Bernas, Pawel R. Kiela, J. Steven Alexander, Marlys H. Witte, Sarah Daley, Jalicia Washington

Publikováno v: Inflamm Bowel Dis

BackgroundInflammatory bowel disease (IBD) is characterized by chronic inflammation, which can progress to colorectal cancer, with duration of disease being the most important risk factor. Although many factors are involved, the pathogenic link betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa03dbd8c0f8080ccab31552fc0d734b
https://doi.org/10.1093/ibd/izz112

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Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease

Publikováno v: Alzheimer'sdementia : the journal of the Alzheimer's Association. 18(8)

INTRODUCTION Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHI) typically sustained by contact sport athletes. Post-translation modifications to tau in CTE have not been well delineat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d879643da6cdf5b1a716b668cb6ab16
https://pubmed.ncbi.nlm.nih.gov/34854540

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A comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease

Publikováno v: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)

Background Cerebrospinal fluid (CSF) tau and beta-amyloid levels in chronic traumatic encephalopathy (CTE), a disease which can be clinically indistinguishable from Alzheimer’s disease (AD), are largely unknown. We examined postmortem CSF analytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935172bf9f29e52dba5410df11c5385b
https://pubmed.ncbi.nlm.nih.gov/35139894

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