A loop-counting method for covariate-corrected low-rank biclustering of gene-expression and genome-wide association study data.

Autor: Aaditya V Rangan, Caroline C McGrouther, John Kelsoe, Nicholas Schork, Eli Stahl, Qian Zhu, Arjun Krishnan, Vicky Yao, Olga Troyanskaya, Seda Bilaloglu, Preeti Raghavan, Sarah Bergen, Anders Jureus, Mikael Landen, Bipolar Disorders Working Group of the Psychiatric Genomics Consortium

Publikováno v: PLoS Computational Biology, Vol 14, Iss 5, p e1006105 (2018)

A common goal in data-analysis is to sift through a large data-matrix and detect any significant submatrices (i.e., biclusters) that have a low numerical rank. We present a simple algorithm for tackling this biclustering problem. Our algorithm accumu

Externí odkaz: https://doaj.org/article/3516fd8d65ac40969c8cda7731788d4e

POLYGENIC RISK AND BODY MASS INDEX IN THE SWEDEN SCHIZOPHRENIA STUDY

Autor: Kaarina Kowalec, Jie Song, Shuyang Yao, Robert Karlsson, Yi Lu, Sarah Bergen, Arvid Harder, Anna Kähler, Anne-May Österholm, Christina Hultman, Patrick Sullivan

Publikováno v: European Neuropsychopharmacology. 63:e159

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::457fda50070cd3897def51080dd0c6cc
https://doi.org/10.1016/j.euroneuro.2022.07.291

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis

Autor: Andrew Pocklington, Ole Mors, Rolf Adolfsson, James Walters, Hon-Cheong So, Joseph Buxbaum, Douglas Ruderfer, Naomi Wray, Markus Nöthen, Joanne Knight, Silviu-Alin Bacanu, Inez Myin-Germeys, Francis Anthony O'Neill, Sang Hong Lee, Antonio Julià Cano, Peter Visscher, Michael O'Donovan, Morten Mattingsdal, Thomas Folkmann Hansen, Esben Agerbo, Petr Slominsky, Sara Marsal, Joshua Roffman, Jingqin Wu, Ditte Demontis, David Collier, Enrico Domenici, Fritz Zimprich, Alexander Gusev, Hannelore Ehrenreich, Richard Bruggeman, Sarah Bergen, Bryan Mowry, Patrik Magnusson, Lude Franke, Srdjan Djurovic, Kang Sim, Anders Børglum, Sophie Legge, Jakob Grove, Sergi Papiol, Bradley Webb, Elisabeth Stögmann

Publikováno v: Nature genetics
Loh, P-R, Bhatia, G, Gusev, A, Finucane, H K, Bulik-Sullivan, B K, Pollack, S J, Schizophrenia Working Group of the Psychiatric Genomics Consortium (Anders Børglum, Jakob Grove; members of-), O’Donovan, M C, Neale, B M, Patterson, N & Price, A L 2015, ' Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis ', Nature Genetics, vol. 47, pp. 1385–1392 . https://doi.org/10.1038/ng.3431
Nature Genetics, 47(12), 1385-1395. Nature Publishing Group
Nature Genetics

Heritability analyses of genome-wide association study (GWAS) cohorts have yielded important insights into complex disease architecture, and increasing sample sizes hold the promise of further discoveries. Here we analyze the genetic architectures of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28dad041987e781e9127d113493d5fd9
https://cris.maastrichtuniversity.nl/en/publications/400045bf-344b-4490-b12c-226a9110503b

Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder

Autor: J, Song, S E, Bergen, A, Di Florio, R, Karlsson, A, Charney, D M, Ruderfer, E A, Stahl, K D, Chambert, J L, Moran, K, Gordon-Smith, L, Forty, E K, Green, I, Jones, L, Jones, E M, Scolnick, P, Sklar, J W, Smoller, P, Lichtenstein, C, Hultman, N, Craddock, M, Landén, Jordan W, Smoller, Roy H, Perlis, Phil Hyoun, Lee, Victor M, Castro, Alison G, Hoffnagle, Pamela, Sklar, Eli A, Stahl, Shaun M, Purcell, Douglas M, Ruderfer, Alexander W, Charney, Panos, Roussos, Carlos Pato, Michele Pato, Helen, Medeiros, Janet, Sobel, Nick, Craddock, Ian, Jones, Liz, Forty, Arianna Di, Florio, Elaine, Green, Lisa, Jones, Katherine, Gordon-Smith, Mikael, Landen, Christina, Hultman, Anders, Jureus, Sarah, Bergen, Steven, McCarroll, Jennifer, Moran, Kimberly, Chambert, Richard A, Belliveau

Publikováno v: Molecular Psychiatry

Lithium is the mainstay prophylactic treatment for bipolar disorder (BD), but treatment response varies considerably across individuals. Patients who respond well to lithium treatment might represent a relatively homogeneous subtype of this genetical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e8a45b9366a635936bbe138cf7e519
https://pubmed.ncbi.nlm.nih.gov/28194006

Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis

Autor: Nancy Buccola, Andrew McQuillin, James Walters, Sven Cichon, Ole A. Andreassen, Douglas Ruderfer, Markus Nöthen, Hywel Williams, Danielle Posthuma, Eske Derks, Inez Myin-Germeys, Draga Toncheva, Anders Rosengren, Paul Lichtenstein, Stanley Zammit, Michael O'Donovan, Morten Mattingsdal, Ingrid Agartz, Thomas Folkmann Hansen, Robert Freedman, Donald Black, Pierandrea Muglia, Richard Bruggeman, Manuel Mattheisen, Sarah Bergen, Andrew McIntosh, Bryan Mowry, Srdjan Djurovic, Stephan Ripke

Publikováno v: Derks, E M, Vorstman, J A S, Ripke, S, Kahn, R S, Posthuma, D & Ophoff, R A 2012, ' Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis ', PLoS ONE, vol. 7, no. 6, e37852, pp. e37852 . https://doi.org/10.1371/journal.pone.0037852
PloS one, vol 7, iss 6
PLoS ONE, 7(6). Public Library of Science
PLoS ONE, 7(6):e37852. Public Library of Science
PLoS ONE
PLoS ONE, Vol 7, Iss 6, p e37852 (2012)
Derks, E M, Vorstman, J A S, Ripke, S, Kahn, R S, Ophoff, R A, Craddock, N J, Escott-Price, V, Hamshere, M L, Holmans, P A, Kirov, G, O'Donovan, M C, Owen, M J & Zammit, S 2012, ' Investigation of the genetic association between quantitative measures of psychosis and schizophrenia : A polygenic risk score analysis ', PLoS ONE, vol. 7, no. 6, e37852 . https://doi.org/10.1371/journal.pone.0037852
PLOS ONE, 7(6):e37852. Public Library of Science

The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we identified five quantitative m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde7443984db68842196ca7cf75767e4
https://research.vumc.nl/ws/files/293540/301676.pdf