Discovery of Nirmatrelvir Resistance Mutations in SARS-CoV-2 3CLpro: A Computational-Experimental Approach.

Autor: Havranek B; Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.; ComputePharma, LLC, Chicago, Illinois 60607, United States., Demissie R; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60607, United States.; Biophysics Core at Research Resource Center, University of Illinois at Chicago, Chicago, Illinois 60607, United States., Lee H; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60607, United States.; Biophysics Core at Research Resource Center, University of Illinois at Chicago, Chicago, Illinois 60607, United States., Lan S; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, United States.; Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States., Zhang H; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, United States.; Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States., Sarafianos S; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, United States.; Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States., Ayitou AJ; Department of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States., Islam SM; ComputePharma, LLC, Chicago, Illinois 60607, United States.; Department of Chemistry, Delaware State University, Dover, Delaware 19901, United States.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2023 Nov 27; Vol. 63 (22), pp. 7180-7188. Date of Electronic Publication: 2023 Nov 10.

G-quadruplex formation in RNA aptamers selected for binding to HIV-1 capsid.

Autor: Mayer, Miles D.^1,2 (AUTHOR), Lange, Margaret J.^1,2 (AUTHOR) langemj@missouri.edu

Publikováno v: Frontiers in Chemistry. 2024, p1-13. 13p.

Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations.

Autor: Yasutake, Yoshiaki^1,2 (AUTHOR) y-yasutake@aist.go.jp, Hattori, Shin-ichiro³ (AUTHOR), Kumamoto, Hiroki⁴ (AUTHOR), Tamura, Noriko¹ (AUTHOR), Maeda, Kenji^3,5 (AUTHOR), Mitsuya, Hiroaki^3,6,7 (AUTHOR) hmitsuya@hosp.ncgm.go.jp

Publikováno v: Scientific Reports. 7/8/2024, Vol. 14 Issue 1, p1-13. 13p.

针对人类免疫缺陷病毒结构蛋白 Gag-Pol的抑制剂及其 作用机制研究进展.

Autor: 黄国锋¹, 李聪宜¹, 王 虹¹, 张文艳¹ zhangwenyan@jlu.edu.cn

Publikováno v: Journal of Jilin University (Medicine Edition). Jul2024, Vol. 50 Issue 4, p1156-1163. 8p.

Small ubiquitin-like modifier-tag and modified protein purification significantly increase the quality and quantity of recombinant African swine fever virus p30 protein.

Autor: Jullada Chootip¹ jullada.cho@ku.th, Payuda Hansoongnern^1,2 payuda.han@ncr.nstda.or.th, Nattarat Thangthamniyom¹ nattarat.tha@cpf.co.th, Sirin Theerawatanasirikul³ fvetsrth@ku.ac.th, Penpitcha Chankeeree¹ penpitchac56@gmail.com, Challika Kaewborisuth² challika.kae@biotec.or.th, Porntippa Lekcharoensuk^1,4 fvetptn@ku.ac.th

Publikováno v: Veterinary World. May2024, Vol. 17 Issue 5, p1157-1167. 11p.